دورية أكاديمية
Evaluation of the Brain Cellular Damage during Liver Transplantations
| العنوان: | Evaluation of the Brain Cellular Damage during Liver Transplantations |
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| المؤلفون: | Sezer, E., Deniz, M. N., Tetik, A., Ulukaya, S. |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2023 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Liver transplantation, Protein, Neuroinflammation, Injury, Serum, Association, Anesthesia, Brain, Neuron-specific enolase and glial fibrillary acidic protein, Neuronal damage, S100 beta protein, Postoperative Cognitive Dysfunction, Neuron-Specific Enolase, N-Acetylcysteine, Cardiac-Surgery |
| الوصف: | Background:Neuroinflammation in patients undergoing major surgery can lead to neuronal damage, and neuronal damage can be detected through the measurement of biochemical markers of brain damage. S100 beta (S100 ; beta;), neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) levels are considered good biomarkers to detect brain damage that emerged with neurotoxicity. Aim:To evaluate neuronal damage during liver transplantations. Materials and Methods:After approval of the ethics committee and patient consents, preoperative and postoperative cognitive functions of 33 patients undergoing liver transplantation were measured using the Mini Mental State Examination (MMSE), whereas simultaneous neuronal damage was evaluated through the measurement of S100 ; beta;, NSE, and GFAP levels. Results:There was no statistically significant difference between preoperative and postoperative MMSE. There was a statistically significant decrease in postoperative GFAP (P 0.05) and a statistically significant increase in NSE (P 0.05) compared to preoperative values. The decrease in S100 ; beta; (P > 0.05) level was statistically insignificant. Conclusions:Neuroprotective approaches in anesthesia protocol protect patients from brain damage during liver transplantation and prevent the development of postoperative cognitive dysfunction. Since the significant increase in NSE levels during liver transplantations was deemed to have been associated with causes other than neuronal damage, NSE should not be evaluated as a marker of brain damage in these operations. ; nbsp;This work was supported by the Ege University Scientific Research Project Izmir, Turkey. Funding Number: 18-TIP-026. ; Ege University Scientific Research Project Izmir, Turkey [18-TIP-026] |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2229-7731 1119-3077 |
| العلاقة: | Nigerian Journal of Clinical Practice; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.4103/njcp.njcp_332_22Test; https://hdl.handle.net/11454/91347Test; 26; 1063; 1068 |
| DOI: | 10.4103/njcp.njcp_332_22 |
| الإتاحة: | https://doi.org/10.4103/njcp.njcp_332_22Test https://hdl.handle.net/11454/91347Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.AA4B5A73 |
| قاعدة البيانات: | BASE |
| تدمد: | 22297731 11193077 |
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| DOI: | 10.4103/njcp.njcp_332_22 |