Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants
| العنوان: | Early life serum neurofilament dynamics predict neurodevelopmental outcome of preterm infants |
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| المؤلفون: | Birgit Pimpel, Jens Kuhle, Annalisa Hauck, Andrew Atkinson, Katharina Goeral, Renate Fuiko, Katrin Klebermass-Schrehof, Monika Olischar, Michael Wagner, David Leppert, Angelika Berger, Sven Wellmann |
| المصدر: | Journal of Neurology |
| بيانات النشر: | Springer Berlin Heidelberg, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Adolescent, Neurodevelopment, 610 Medizin, Intermediate Filaments, Neurofilament, Logistic regression, Bayley Scales of Infant Development, 03 medical and health sciences, Brain damage, 0302 clinical medicine, Cerebrospinal fluid, Interquartile range, Neurofilament Proteins, 030225 pediatrics, medicine, Humans, Prospective Studies, Children, ddc:610, Original Communication, business.industry, Cerebral infarction, Infant, Newborn, Biomarker, medicine.disease, Hydrocephalus, Neurofilament · Brain damage · Neurodevelopment · Children · Biomarker, Intraventricular hemorrhage, Neurology, Gestation, Neurology (clinical), business, 030217 neurology & neurosurgery, Biomarkers, Infant, Premature |
| الوصف: | Background and purpose To determine whether neurofilament light chain (NfL), a promising serum and cerebrospinal fluid (CSF) biomarker of neuroaxonal damage, predicts functional outcome in preterm infants with neonatal brain injury. Methods Our prospective observational study used a sensitive single-molecule array assay to measure serum and CSF NfL concentrations in preterm infants with moderate to severe peri/intraventricular hemorrhage (PIVH). We determined temporal serum and CSF NfL profiles from the initial diagnosis of PIVH until term-equivalent age and their association with clinical and neurodevelopmental outcome until 2 years of age assessed by Bayley Scales of Infant Development (3rd edition). We fitted univariate and multivariate logistic regression models to determine risk factors for poor motor and cognitive development. Results The study included 48 infants born at n = 25)-but not post-hemorrhagic hydrocephalus requiring external ventricular drainage (n = 29) nor any other impairment-was independently associated with sNfL. Multivariate logistic regression models identified sNfL as an independent predictor of poor motor outcome or death at 1 and 2 years. Conclusions Serum neurofilament light chain dynamics in the first weeks of life predict motor outcome in preterm infants with PIVH. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1432-1459 0340-5354 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ce014640bea1c220104fc1ae6fadd3Test http://europepmc.org/articles/PMC8217001Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....38ce014640bea1c220104fc1ae6fadd3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321459 03405354 |
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