Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review
| العنوان: | Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours: a Systematic Literature Review |
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| المؤلفون: | Zaher Toumi, Katrina Clair Cockburn, Alison Mackie, Peter Julyan |
| المصدر: | Journal of Gastrointestinal Surgery |
| بيانات النشر: | Springer US, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Radioisotope, medicine.medical_specialty, English language, Review Article, Stomach Neoplasms, Intestinal Neoplasms, medicine, Humans, Gastrointestinal tract, Gastrinoma, Diagnostic techniques, Lesion detection, business.industry, Gastroenterology, Radioguided Surgery, medicine.disease, Pancreatic Neoplasms, Neuroendocrine Tumors, medicine.anatomical_structure, Systematic review, Surgery, Computer-Assisted, Neuroendocrine tumours/surgery, Radiopharmaceutical, Surgery, Radiology, Pancreas, business |
| الوصف: | Background Radioguided surgery (RGS) for gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has been suggested as a way to improve intraoperative lesion detection. This systematic literature review of reports of the use of RGS for GEP-NETs was performed to determine if there is a benefit. Methods A literature search was conducted using Google Scholar and PubMed, and snowballing from any relevant literature. Full-text studies were included if they were published in the English language and reported outcomes of RGS on human subjects with GEP-NETs. Qualitative data synthesis was performed. Results Twenty-six papers including a total of 209 patients were included. The tracers used were predominantly indium-111 pentetreotide, gallium-68 DOTA-peptides, and technetium-99m EDDA/HYNIC-peptides. Heterogeneous protocols make comparisons difficult, but most papers reported a benefit from the use of RGS in tumours in the gastrointestinal tract; utility in localisation of pancreatic tumours was less clear. Time between tracer administration and operation varied: from 16 h to 8 days with indium-111, 0–24 h with technetium-99m, and 19–193 min with gallium-68. Eight teams reported the thresholding technique used for discrimination—four used a ratio, four statistical methods, and one looked at the sensitivity and specificity of different cut-offs. Six teams performed follow-up of 24 patients (three pancreas, eight gastrinoma, 13 gastrointestinal tract) for between 3 months and 3 years. Two patients relapsed (one pancreas, one gastrinoma) between 6 and 12 months post-surgery. Conclusions RGS appears to aid in localisation of gastrointestinal NETs, but the benefit is more equivocal in pancreatic NETs. Further work into outcomes is warranted. |
| اللغة: | English |
| تدمد: | 1873-4626 1091-255X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10da2094e4c4383e5a66b5ec7161c9b3Test http://europepmc.org/articles/PMC8654712Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....10da2094e4c4383e5a66b5ec7161c9b3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18734626 1091255X |
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