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المؤلفون: Shiying Chen, Wensheng Yu, Joseph A. Kozlowski, Daniel Lundell, Seong Heon Kim, Ling Tong, Shelby Umland, Xiaoda Niu, Vinay Girijavallabhan, Lei Chen, Aneta Kosinski, Guowei Zhou, Mengwei Hu, Neng-Yang Shih, Bandarpalle B. Shankar, De-Yi Yang
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3704-3708
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Potency, Prodrugs, Pentanoic Acids, Molecular Biology, Whole blood, chemistry.chemical_classification, Hydantoins, Organic Chemistry, Haplorhini, Prodrug, Tace inhibitor, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, chemistry, Area Under Curve, Molecular Medicine, Lead compound, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5125137f478242040971d76ea3dc87f8Test
https://doi.org/10.1016/j.bmcl.2017.07.007Test -
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المؤلفون: Guowei Zhou, Liping Yang, Neng-Yang Shih, M. Arshad Siddiqui, Vinay Girijavallabhan, Shiying Chen, Lei Chen, Dansu Li, Peter Orth, Zhuyan Guo, Bandarpalle B. Shankar, Kristin E. Rosner, Wensheng Yu, Ling Tong, Chaoyang Dai, Joseph A. Kozlowski, Aneta Kosinski, Xiaoda Niu, Seong Heon Kim, Daniel Lundell, Shelby Umland, Janeta Popovici-Muller
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3037-3042
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, Animals, Humans, Potency, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, Chemistry, Hydantoins, Organic Chemistry, Haplorhini, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, Area Under Curve, Molecular Medicine, Tumor necrosis factor alpha, Half-Life, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9ae78bb60384e5c554a062fa84b16eTest
https://doi.org/10.1016/j.bmcl.2017.05.062Test -
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المؤلفون: Liang Zhu, Weihong Jin, Xin Yao, Hong Mei, Abdul Basit Alhassan, William T. Windsor, Donna Carr, Li Xiao, Sunil Paliwal, Neng-Yang Shih, Sun Robert, Gerald W. Shipps, Sobhana Babu Boga, Yang Nan, Joseph Kelly, Alexei V. Buevich, Brian Long, Paul Kirschmeier, Bradley Sherborne, Kiran Muppalla, Stuart Black, Hon-Chung Tsui, Doll Ronald J, Hugh Y. Zhu, Stacey A. Taylor, Subrahmanyam Gudipati, Gongjie Liu, Alan B. Cooper, Li-Kang Zhang, Kathleen Cox, Robert Bishop, David Hesk, Yongqi Deng, Alan Hruza, Mehul D. Patel, Xiaolei Gao, Priya Dayananth, Tong Wang, Desai Jagdish A, Wang James J-S, Ahmed A. Samatar
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Kinase, business.industry, Organic Chemistry, Cancer, Pharmacology, medicine.disease, Biochemistry, Dual mechanism, Pyrrolidine, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Pharmacokinetics, Drug Discovery, Medicine, Dosing, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2250ac0d2e55d7a37e61d512ca2156Test
https://europepmc.org/articles/PMC6047169Test/ -
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المؤلفون: Pinto Patrick A, F. George Njoroge, Joseph A. Kozlowski, K.-C. Cheng, Hsueh-Cheng Huang, Frank Bennet, Tin-Yau Chan, Oleg Selyutin, Sony Agrawal, Yuhua Huang, Bancha Vibulbhan, Francisco Velazquez, Stuart B. Rosenblum, Srikanth Venkatraman, Yueheng Jiang, Gopinadhan N. Anilkumar, Cheng Li, Kevin X. Chen, Qingbei Zeng, Charles A. Lesburg, Neng-Yang Shih
المصدر: ACS Medicinal Chemistry Letters. 5:244-248
مصطلحات موضوعية: Indole test, Bicyclic molecule, Hepatitis C virus, Organic Chemistry, Biology, Prodrug, Pharmacology, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Transferase, Potency, Lead compound, Quinazolinone
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d6b7cd7274b7db5b44ce371671e837Test
https://doi.org/10.1021/ml400192wTest -
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المؤلفون: Stuart B. Rosenblum, Stephen Gavalas, Francisco Velazquez, Pinto Patrick A, Oleg Selyutin, Neng-Yang Shih, Yuhua Huang, Wanli Wu, Sony Agrawal, Yueheng Jiang, Srikanth Venkatraman, Joseph A. Kozlowski, Chuan-kui Jiang, Hsueh-Cheng Huang, Jose S. Duca, Anilkumar G. Nair, Bancha Vibulbhan, Eric Ferrari, Kevin X. Chen, Cheng Li, Charles A. Lesburg, F. George Njoroge, Frank Bennett, Qingbei Zeng
المصدر: Bioorganic & Medicinal Chemistry. 21:2007-2017
مصطلحات موضوعية: Indoles, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, RNA-dependent RNA polymerase, Hepacivirus, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Humans, Replicon, Binding site, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, virus diseases, RNA-Dependent RNA Polymerase, Hepatitis C, Virology, digestive system diseases, Molecular Docking Simulation, Enzyme, chemistry, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016854d014a0a4d91a3500623598032Test
https://doi.org/10.1016/j.bmc.2013.01.024Test -
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المؤلفون: Jeremy Clark, Xiao Tong, Ashok Arasappan, Randall R. Rossman, Anita T. Fowler, Subramaniam Ananthan, Vinay Girijavallabhan, Feng Geng, Regina Huelgas, Neng-Yang Shih, F. George Njoroge, Hollis S. Kezar, Joseph A. Maddry, Yuhua Huang, Frank Bennett, Cheng Li, John J. Piwinski, Cecil D. Kwong, John A. Secrist, Stephanie Curry, Abhijit Roychowdhury, Malcolm MacCoss, Robert C. Reynolds, Hsueh-Cheng Huang, Robert Chase
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5144-5149
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Virus Replication, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Animals, Moiety, Replicon, Enzyme Inhibitors, Benzofuran, Furans, Molecular Biology, Benzofurans, Organic Chemistry, Pyrimidine Nucleosides, RNA-Dependent RNA Polymerase, Rats, Pyrimidines, Liver, chemistry, Alkoxy group, Molecular Medicine, Selectivity, Half-Life, Methyl group
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19a20c57978b9eb8444e2b3affa03ceTest
https://doi.org/10.1016/j.bmcl.2012.06.021Test -
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المؤلفون: Ashok Arasappan, Seong-Heon Kim, Robert C. Reynolds, Cheng Li, Aneta Kosinski, Jeremy Clark, Joseph A. Kozlowski, Ling Tong, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, F. George Njoroge, Anita T. Fowler, Vishal Verma, Subramaniam Ananthan, Randall R. Rossman, Robert Chase, Neng-Yang Shih, Joseph A. Maddry, John A. Secrist, Cecil D. Kwong, Hollis S. Kezar, Abhijit Roychowdhury, Stephanie Curry, Malcolm MacCoss, Hsueh-Cheng Huang, Razia Rizvi, Frank Bennett, Stephen Gavalas, Yuhua Huang, Francisco Velazquez, Alvarez Carmen S, Feng Geng, Xiao Tong, John J. Piwinski, Regina Huelgas, Bandarpalle B. Shankar, Srikanth Venkatraman
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3229-3234
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Rodentia, Hepacivirus, Virus Replication, Antiviral Agents, Methylation, Biochemistry, Residue (chemistry), chemistry.chemical_compound, Dogs, Species Specificity, In vivo, Drug Discovery, Animals, Potency, Moiety, Benzothiazoles, Replicon, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, Pyrimidines, Benzothiazole, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e593455015b9cae754dc9b1385747bTest
https://doi.org/10.1016/j.bmcl.2012.03.036Test -
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المؤلفون: Oleg Selyutin, F. George Njoroge, Qingbei Zeng, Stuart B. Rosenblum, Joseph A. Kozlowski, Mousumi Sannigrahi, Yueheng Jiang, Frank Bennett, Neng-Yang Shih, Eric Ferrari, Gopinadhan N. Anilkumar, Bancha Vibulbhan, Hsueh-Cheng Huang, Jose S. Duca, Li Wang, Pinto Patrick A, Stephen Gavalas, Haiyan Pu, Sony Agrawal, Kevin X. Chen, Charles A. Lesburg, Yuhua Huang, Tin-Yau Chan, Chuan-kui Jiang, Francisco Velazquez, Srikanth Venkatraman
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:713-717
مصطلحات موضوعية: Models, Molecular, Indoles, Isostere, Chemistry, Pharmaceutical, viruses, Carboxylic acid, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Ns5b polymerase, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Moiety, Replicon, Molecular Biology, NS5B, chemistry.chemical_classification, Indole test, Sulfonamides, Organic Chemistry, virus diseases, Hydrogen Bonding, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Sulfonamide, Models, Chemical, chemistry, Drug Design, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f74a4343432a940d8f437e79028a4cdTest
https://doi.org/10.1016/j.bmcl.2011.10.041Test -
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المؤلفون: Neng-Yang Shih, Joseph A. Maddry, Xiao Tong, Subramaniam Ananthan, Cheng Li, Jeremy Clark, Feng Geng, Hollis S. Kezar, Cecil D. Kwong, John J. Piwinski, Abhijit Roychowdhury, Robert C. Reynolds, Anita T. Fowler, Ashok Arasappan, Hsueh-Cheng Huang, John A. Secrist, F. George Njoroge, Boris Feld
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1160-1164
مصطلحات موضوعية: Clinical Biochemistry, Substituent, Pharmaceutical Science, RNA-dependent RNA polymerase, Stereoisomerism, Hepacivirus, Microbial Sensitivity Tests, Virus Replication, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Potency, Structure–activity relationship, Moiety, Replicon, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Hepatitis C, Virology, Rats, Pyrimidines, chemistry, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a01a2091efa205ec0a5d00edbf54a02Test
https://doi.org/10.1016/j.bmcl.2011.11.091Test -
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المؤلفون: Xiaolian Xu, Seong Heon Kim, Qingbei Zeng, Joseph A. Kozlowski, Carolyn DiIanni Carroll, Neng-Yang Shih, Baldwin John J, Wensheng Yu, Yueheng Jiang, Guizhen Dong, Yuefei Shao, Brian F. Mcguinness, Gopinadhan N. Anilkumar, Lisa Guise Zawacki, Doug W. Hobbs, Chung-Her Jenh, James W. Hall, Stuart B. Rosenblum, Bandarpalle B. Shankar, De-Yi Yang
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6982-6986
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Receptors, CXCR3, Clinical Biochemistry, hERG, Pharmaceutical Science, C-C chemokine receptor type 7, C-C chemokine receptor type 6, CCR5 receptor antagonist, Pharmacology, Biochemistry, Piperazines, Inhibitory Concentration 50, Structure-Activity Relationship, Chemokine receptor, stomatognathic system, Drug Discovery, Animals, Structure–activity relationship, cardiovascular diseases, skin and connective tissue diseases, Molecular Biology, Molecular Structure, biology, Chemistry, Organic Chemistry, Rats, stomatognathic diseases, Pyrazines, biology.protein, Molecular Medicine, Receptor antagonist activity, Protein Binding, CCL21
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c65b7371750c0100d6b469612e6fd2fTest
https://doi.org/10.1016/j.bmcl.2011.09.120Test