التفاصيل البيبلوغرافية
| العنوان: |
Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study |
| المؤلفون: |
Ng, David Chun‐Ern, Liew, Chuin‐Hen, Tan, Kah Kee, Awang, Elida Hanan binti, Nazri, Farah Nuruliayana binti Ahmad, Maran, Asuwani K. Tamil, Mohan, Vishnu Arvindran a/l Chandra, Ramachandran, Durairaaj, Chok, Michelle, Teh, Cheah Hooi, Mohamad Nor, Airena, Baharuddin, Suhaila bt, Khoo, Erwin Jiayuan |
| المساهمون: |
International Medical University |
| المصدر: |
The Clinical Respiratory Journal ; volume 18, issue 3 ; ISSN 1752-6981 1752-699X |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Introduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children. Methods This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia. Demographic, clinical presentation, resource utilisation and outcome data were analysed. Propensity score matching was used to balance cohorts based on key demographic and clinical characteristics. Results This study included 192 patients, comprising 112 with hMPV and 80 with RSV. hMPV patients were older (median age 20.5 vs. 9.4 months, p < 0.001) and had a higher incidence of comorbidities (24.1% vs. 7.5%, p = 0.003). Fever was more common in the hMPV group (97.3% vs. 73.8%, p < 0.001), but the other clinical manifestations were similar. Postmatching analysis showed higher corticosteroid use in the hMPV group ( p = 0.01). No significant differences were observed in the use of other resources, PICU admissions, duration of hospitalisation or mortality rates between both groups. Conclusion hMPV and RSV infections in children share similar clinical manifestations and outcomes, with hMPV affecting older children and showing higher corticosteroid usage. These findings emphasise the need for equal clinical vigilance for both hMPV and RSV in paediatric respiratory infections. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/crj.13747 |
| الإتاحة: |
https://doi.org/10.1111/crj.13747Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.7901619B |
| قاعدة البيانات: |
BASE |
