المؤلفون: Amin, Hawraz Ibrahim M., Ruiz-Pino, Francisco, Collado, Juan A., Appendino, Giovanni, Tena-Sempere, Manuel, Munoz, Eduardo, Caprioglio, Diego

المساهمون: Amin, Hawraz Ibrahim M., Ruiz-Pino, Francisco, Collado, Juan A., Appendino, Giovanni, Tena-Sempere, Manuel, Munoz, Eduardo, Caprioglio, Diego

مصطلحات موضوعية: Despite their early discovery, the bioactivity of acidic cannabinoids was long overlooked. Issues of stability and a pharmacological focus on Δ9-THC and its biological profile combined to relegate the non-narcotic native form of phytocannabinoids to a sort of investigational limbo. Recent studies have disclosed an attractive bioactivity profile for specific acidic phytocannabinoids but concerns about their limited stability have remained substantially unaddressed. To solve this issue, we have developed the hydroxamate derivatives of Δ8-tetrahydrocannabinolic acid-A (Δ8-THCA-AH, 6) and cannabidiolic acid (CBDAH, 5) as novel acidic cannabinoid bioisosteres, and we report here their synthesis and bioactivity profile against specific cannabinoid targets, as well as promising in vivo activity in a murine model of polycystic ovary syndrome (PCOS) associated with obesity

العلاقة: volume:2; journal:FRONTIERS IN NATURAL PRODUCTS; https://hdl.handle.net/11579/177925Test; https://www.frontiersin.org/articles/10.3389/fntpr.2023.1190053/fullTest

الإتاحة: https://doi.org/10.3389/fntpr.2023.1190053Test
https://hdl.handle.net/11579/177925Test

المؤلفون: Megan I. Chambers (9567157), Justine E. Giffen-Lemieux (8565333), Rabi A. Musah (319873)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Ecology, Biological Sciences not elsewhere classified, typically require time, traditional chromatographic approaches, suitable internal standard, resolution mass spectrometry, identified several plant, plant material unknowns, raw salvia leaves, major psychoactive component, commercial salvia products, aka salvia ), salvia plant material, increasing recreational use, e ., salvinorin, bulk material, salvia divinorum, psychoactive effects, recent years, rapidly screen, public health, native form, national laboratories, hallucinogenic salvinorin, federal regulation, derived materials

العلاقة: https://figshare.com/articles/journal_contribution/Rapid_Detection_and_Quantification_of_Hallucinogenic_Salvinorin_A_in_Commercial_Salvia_divinorum_Products_by_DART-HRMS/21766745Test

الإتاحة: https://doi.org/10.1021/acsomega.2c06106.s001Test

المؤلفون: Emma K. Sisley (8560998), Oliver J. Hale (7571543), Iain B. Styles (587047), Helen J. Cooper (1261293)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Chemical Sciences not elsewhere classified, e ., parvalbumin, desorption electrospray ionization, free spatial mapping, thin tissue sections, tandem mass spectrometry, rat brain label, carbonic anhydrase 2, 2 +, binding proteins parvalbumin, rat brain, mass spectrometry, carbonic anhydrase, binding proteins, spatial resolution, spatial distributions, tissue environment, providing opportunities, noncovalent interactions, native form, multiple rounds, gtpase ran, drug interactions, disease progression, 200 μm

العلاقة: https://figshare.com/articles/journal_contribution/Native_Ambient_Mass_Spectrometry_Imaging_of_Ligand-Bound_and_Metal-Bound_Proteins_in_Rat_Brain/19067840Test

الإتاحة: https://doi.org/10.1021/jacs.1c10032.s001Test

المؤلفون: Masanori Kaneko (1313520), Yoshinori Takano (1265742), Masashi Kamo (6843473), Kazuya Morimoto (841340), Takuro Nunoura (180983), Naohiko Ohkouchi (462905)

مصطلحات موضوعية: Molecular Biology, Ecology, Cancer, Inorganic Chemistry, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sulfate reduction zone, shimokita peninsula originates, 60 ° c, epimerization well follow, drilled sediments used, coenzyme f430 analysis, applied coenzyme f430, living methanogen cells, degradation experiments revealed, native f430 detected, f430 detected, coenzyme f430, native form, methyl coenzyme, degradation experiments, f430 contents, f430 concentration, living methanogens, ∼ 70, various temperatures, thermodynamic laws, subseafloor sediments, specific biomarker

العلاقة: https://figshare.com/articles/journal_contribution/Insights_into_the_Methanogenic_Population_and_Potential_in_Subsurface_Marine_Sediments_Based_on_Coenzyme_F430_as_a_Function-Specific_Biomarker/16614008Test

الإتاحة: https://doi.org/10.1021/jacsau.1c00307.s001Test

المؤلفون: Zhicheng Le (6030347), Zepeng He (11724810), Hong Liu (50694), Lixin Liu (676169), Zhijia Liu (2834435), Yongming Chen (324923)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Genetics, Pharmacology, Biotechnology, Immunology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, comparable biological activity, antioxidant superoxide dismutase, term enzymatic stability, particle encapsulation providing, inflammatory bowel disease, potential enzyme therapeutics, enzyme therapeutics, particle surface, inflammatory diseases, enzymatic degradation, targeting properties, sequential self, physical barrier, penetrating ability, near future, native form, local treatment, intrarectal administration, hostile environments

العلاقة: https://figshare.com/articles/journal_contribution/Antioxidant_Enzymes_Sequestered_within_Lipid_Polymer_Hybrid_Nanoparticles_for_the_Local_Treatment_of_Inflammatory_Bowel_Disease/17041284Test

الإتاحة: https://doi.org/10.1021/acsami.1c19457.s001Test

المؤلفون: Leo K. B. Tam (11772325), Ligang Yu (11772328), Roy C. H. Wong (4230250), Wing-Ping Fong (296479), Dennis K. P. Ng (8735214), Pui-Chi Lo (1801342)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Sociology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, targeted photodynamic therapy, photoinduced electron transfer, native form due, hepg2 cancer cells, connected via one, conjugates could serve, upon light irradiation, reduced upon pre, increased upon post, dual cathepsin b, cathepsin b levels, cathepsin b inhibitor, intracellular fluorescence intensity, gly peptide linker, 50 , 21 – 0, free phthalocyanine units, two cathepsin b, cathepsin b, phthalocyanine units, upon internalization

العلاقة: https://figshare.com/articles/journal_contribution/Dual_Cathepsin_B_and_Glutathione-Activated_Dimeric_and_Trimeric_Phthalocyanine-Based_Photodynamic_Molecular_Beacons_for_Targeted_Photodynamic_Therapy/17100106Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01634.s001Test

المؤلفون: Jong-Eun Park, Geum-Seok Jeong, Hyun-Woo Lee, Hoon Kim

المصدر: Microorganisms; Volume 9; Issue 8; Pages: 1614

مصطلحات موضوعية: compost metagenomic library, family IV esterase, family VIII esterase, glyceryl tributyrate hydrolysis, oligomeric native form, organic solvent stability, broad substrate specificity

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Microbial Biotechnology; https://dx.doi.org/10.3390/microorganisms9081614Test

الإتاحة: https://doi.org/10.3390/microorganisms9081614Test

المؤلفون: Jiaying Guo, Muxiao Li, Yali Sun, Long Yu, Pei He, Zheng Nie, Xueyan Zhan, Yangnan Zhao, Xiaoying Luo, Sen Wang, Siqi Aoyang, Qin Liu, Cuiqin Huang, Lan He, Junlong Zhao

المصدر: Parasites & Vectors, Vol 11, Iss 1, Pp 1-11 (2018)

مصطلحات موضوعية: Spherical body, Apical organelle complex, Babesia orientalis, Native form, Immunoreactivity, Cellular localization, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13071-018-3018-yTest; https://doaj.org/toc/1756-3305Test

الوصول الحر: https://doaj.org/article/73cee17584d244de8bc1cc2e6983abcfTest

المؤلفون: Hyun Woo Lee, Jong Eun Park, Hoon Kim, Geum-Seok Jeong

المصدر: Microorganisms
Volume 9
Issue 8
Microorganisms, Vol 9, Iss 1614, p 1614 (2021)

مصطلحات موضوعية: 0106 biological sciences, Microbiology (medical), Stereochemistry, QH301-705.5, Dimer, 01 natural sciences, Microbiology, Esterase, Article, broad substrate specificity, 03 medical and health sciences, Carboxylesterase, chemistry.chemical_compound, Hydrolysis, Tetramer, 010608 biotechnology, Virology, organic solvent stability, Biology (General), compost metagenomic library, family VIII esterase, 030304 developmental biology, Thermostability, chemistry.chemical_classification, 0303 health sciences, glyceryl tributyrate hydrolysis, oligomeric native form, Amino acid, family IV esterase, chemistry, Methanol

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfc10386fe21a511777cfbdd2ed7d29Test

المؤلفون: Santoni, E, Scatragli, S, Smulevich, G., SINIBALDI, FEDERICA, FIORUCCI, LAURA, SANTUCCI, ROBERTO

المساهمون: Santoni, E, Scatragli, S, Sinibaldi, F, Fiorucci, L, Santucci, R, Smulevich, G

مصطلحات موضوعية: Cytochrome c fragment, Electronic absorption, Non-native form, pH effect, Resonance Raman spectroscopy, Settore BIO/10 - BIOCHIMICA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/15149817; info:eu-repo/semantics/altIdentifier/wos/WOS:000221939000021; volume:98; issue:6; firstpage:1067; lastpage:1077; numberofpages:11; journal:JOURNAL OF INORGANIC BIOCHEMISTRY; http://hdl.handle.net/2108/34638Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-2442581060

الإتاحة: https://doi.org/10.1016/j.jinorgbio.2004.02.026Test
http://hdl.handle.net/2108/34638Test