نتائج البحث - "Nathan Yumibe"

1

دورية أكاديمية

Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide‑1 Receptor

المؤلفون: Francis S. Willard (10306561), David B. Wainscott (10306564), Aaron D. Showalter (10306567), Cynthia Stutsman (10306570), Wenzhen Ma (546079), Guemalli R. Cardona (10306573), Richard W. Zink (2232373), Christopher M. Corkins (10306576), Qi Chen (144168), Nathan Yumibe (2527282), Javier Agejas (1581091), Graham R. Cumming (4376143), José Miguel Minguez (10306579), Alma Jiménez (1816990), Ana I. Mateo (3024924), Ana M. Castaño (10306582), Daniel A. Briere (10306585), Kyle W. Sloop (10306588), Ana B. Bueno (1451155)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Physiology, Pharmacology, Immunology, Developmental Biology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, LSN 3318839 increases, β- arrestin recruitment, glucose-dependent insulin secretion, LSN 3318839 support, GLP -1R potentiation, GLP -1R, Ex vivo experiments show, LSN 3318839

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_an_Orally_Efficacious_Positive_Allosteric_Modulator_of_the_Glucagon-like_Peptide_1_Receptor/14219779Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00029.s001Test

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Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor

المؤلفون: Daniel A. Briere, David B. Wainscott, José Miguel Minguez, Cynthia Stutsman, Qi Chen, Ana B. Bueno, Alma Jiménez, Kyle W. Sloop, Ana I. Mateo, Guemalli R. Cardona, Wenzhen Ma, Aaron D. Showalter, Graham R Cumming, Ana M. Castaño, Francis S. Willard, Richard W. Zink, Javier Agejas, Nathan Yumibe, Christopher M Corkins

المصدر: Journal of Medicinal Chemistry. 64:3439-3448

مصطلحات موضوعية: Blood Glucose, Models, Molecular, Agonist, endocrine system, Allosteric modulator, medicine.drug_class, Metabolite, Administration, Oral, Pharmacology, 01 natural sciences, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Receptor, 030304 developmental biology, 0303 health sciences, Chemistry, digestive, oral, and skin physiology, Long-term potentiation, Ligand (biochemistry), Glucagon-like peptide-1, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f48ac2debed19ca46755aefd201e2e9Test
https://doi.org/10.1021/acs.jmedchem.1c00029Test

3

Pharmacokinetics of intravenous and oral metformin and r,s-verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs

المؤلفون: David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard

المصدر: International Journal of Pharmacokinetics. 2:81-91

مصطلحات موضوعية: Plasma clearance, genetic structures, 040301 veterinary sciences, business.industry, 04 agricultural and veterinary sciences, Pharmacology, 030226 pharmacology & pharmacy, eye diseases, Bioavailability, Metformin, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Medicine, Verapamil, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::89eb2dfefa3b5798e4b7197e18fc7dc7Test
https://doi.org/10.4155/ipk-2016-0002Test

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Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats

المؤلفون: David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou

المصدر: Drug Metabolism and Disposition. 44:1184-1192

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, endocrine system diseases, CYP3A, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Substrate Specificity, Rats, Sprague-Dawley, Rosiglitazone, Glibenclamide, Troglitazone, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Cytochrome P-450 Enzyme System, Species Specificity, Pharmacokinetics, Internal medicine, Glyburide, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Hypoglycemic Agents, Canagliflozin, Chromans, Glucuronosyltransferase, Biotransformation, business.industry, nutritional and metabolic diseases, medicine.disease, Metformin, Rats, Zucker, 030104 developmental biology, Endocrinology, Liver, Hepatocytes, Administration, Intravenous, Thiazolidinediones, Sulfotransferases, business, Drug metabolism, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e69d23677d8c4507f2e53434027c9bTest
https://doi.org/10.1124/dmd.116.070623Test

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Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

المصدر: Journal of medicinal chemistry. 61(3)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba33126a14f55ea8f6b1d4d12011e1a1Test
https://pubmed.ncbi.nlm.nih.gov/29236497Test

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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

المصدر: Journal of medicinal chemistry. 59(24)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_treatment, Endogeny, Pharmacology, Diabetes Mellitus, Experimental, Receptors, G-Protein-Coupled, 03 medical and health sciences, Mice, Structure-Activity Relationship, Pharmacokinetics, Piperidines, Free fatty acid receptor 1, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Secretion, Spiro Compounds, Receptor, geography, Mice, Inbred BALB C, geography.geographical_feature_category, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Insulin, Type 2 Diabetes Mellitus, Glucose Tolerance Test, Islet, Rats, Rats, Zucker, Mice, Inbred C57BL, 030104 developmental biology, HEK293 Cells, Diabetes Mellitus, Type 2, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e874164fca96fc6edd42ba967fc574bTest
https://pubmed.ncbi.nlm.nih.gov/27749056Test

7

Design and synthesis of a novel class of dual PPARγ/δ agonists

المؤلفون: Yanping Xu, Nathan Bryan Mantlo, Fatima Iradier, Leonard L. Winneroski, Gary J. Etgen, Chahrzad Montrose-Rafizadeh, Carol L. Broderick, Jason Eric Lamar, Nathan Yumibe, Richard W. Zink, Brian A. Oldham, Jeremy Schulenburg York, Isabel C. Gonzalez

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1052-1055

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::15ce50b2bfd928c1d1472b197a929097Test
https://doi.org/10.1016/j.bmcl.2006.11.029Test

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Tetrahydroisoquinoline PPARγ agonists: Design of novel, highly selective non-TZD antihyperglycemic agents

المؤلفون: Warshawsky Alan M, Chahrzad Montrose-Rafizadeh, Henry James Robert, Rose T. Ajamie, Viswanath Devanarayan, Nathan Yumibe, Elizabeth A. Misener, Richard W. Zink, Daniel A. Briere, Yihong Li, Eric D. Hawkins, Joseph T. Brozinick, Brad Wilken

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6293-6297

مصطلحات موضوعية: Blood Glucose, Models, Molecular, Agonist, medicine.medical_specialty, medicine.drug_class, Peroxisome Proliferator-Activated Receptors, Clinical Biochemistry, Antihyperglycemic Agents, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Pharmacology, Biochemistry, Chemical synthesis, Rosiglitazone, Mice, chemistry.chemical_compound, Tetrahydroisoquinolines, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Molecular Biology, chemistry.chemical_classification, Tetrahydroisoquinoline, Organic Chemistry, Highly selective, PPAR gamma, Endocrinology, chemistry, Nuclear receptor, Molecular Medicine, Thiazolidinediones, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94957c4cce8b27e53fdca0e28edb89f8Test
https://doi.org/10.1016/j.bmcl.2006.09.028Test

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P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors

المؤلفون: Q. May Wang, John I. Glass, Yip Yvonne Yee Mai, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, Nancy June Snyder, Guo Deqi, Jason Eric Lamar

المصدر: Bioorganic & Medicinal Chemistry Letters. 14:257-261

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f275bbea4f02e46d25f244e2fcf482cdTest
https://doi.org/10.1016/j.bmcl.2003.09.075Test

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Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

المؤلفون: Jason Eric Lamar, Ling Jin, Daryl Venable, Lifei Liu, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Q. May Wang, Yip Yvonne Yee Mai, Donna Barket, Robert B. Johnson, Joe Colacino, Mark Wakulchik, John E. Munroe, Beverly A. Heinz, John I. Glass, Congping Xie, Elcira C. Villarreal

المصدر: Bioorganic & Medicinal Chemistry Letters. 14:251-256

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03ae4d6ce258904c379bc3ebcafdec6Test
https://doi.org/10.1016/j.bmcl.2003.09.074Test

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