دورية أكاديمية
Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4
| العنوان: | Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4 |
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| المؤلفون: | Moneeb Ehtesham, Xiangpeng Yuan, Peter Kabos, Nancy H.C. Chung, Gentao Liu, Yasuharu Akasaki, Keith L. Black, John S. Yu |
| المصدر: | Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 3, Pp 287-293 (2004) |
| بيانات النشر: | Elsevier, 2004. |
| سنة النشر: | 2004 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Glioma/brain tumor, neural stem cells, migration, CXCR4, SDF-1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Malignant gliomas spawn disseminated microsatellites, which are largely refractory to currently employed therapies, resulting in eventual tumor recurrence and death. The use of tumor-tropic neural stem cells (NSCs) as delivery vehicles for therapeutic gene products represents an attractive strategy specifically focused at treating these residual neoplastic foci. We wished to elucidate the biological cues governing NSC tropism for glioma. In this context, we describe that tumortropic NSCs comprise largely of astrocytic progenitors expressing chemokine receptor 4 (CXCR4). Blocking of CXCR4 significantly inhibits NSC migration toward the tumor. These findings define specific characteristics associated with the cell populations within transplanted NSCs that demonstrate glioma-tracking behavior. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1476-5586 1522-8002 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1476558604800769Test; https://doaj.org/toc/1476-5586Test; https://doaj.org/toc/1522-8002Test |
| DOI: | 10.1593/neo.03427 |
| الوصول الحر: | https://doaj.org/article/6883aa46203b4b5e9979dc17c263b010Test |
| رقم الانضمام: | edsdoj.6883aa46203b4b5e9979dc17c263b010 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14765586 15228002 |
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| DOI: | 10.1593/neo.03427 |