المؤلفون: Najumudeen, Arafath K., Fey, Sigrid K., Millett, Laura M., Ford, Catriona A., Gilroy, Kathryn, Gunduz, Nuray, Ridgway, Rachel A., Anderson, Eve, Strathdee, Douglas, Clark, William, Nixon, Colin, Morton, Jennifer P., Campbell, Andrew D., Sansom, Owen J.

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: The authors are grateful to the CRUK Scotland Institute Central Services, Histology Services, Transgenics and BSU for technical support and all members of the Sansom lab for discussion of the data and the manuscript. O.J.S. was supported by CRUK grants A21139, A12481, A17196 and A31287 and ERC Starting grant 311301. A.K.N. was supported by Novartis grant awarded to O.J.S. A.K.N. was supported by Academy of Finland grant. S.K.F. was supported by Pancreatic Cancer UK Future Leaders Academy - awarded to O.J.S. and J.P.M. K.G. was supported by CRUK Grand Challenge Specificancer Grand Challenge Consortium (A29055 awarded to O.J.S.). C.F, R.A.R, E.A, D.S, C.N, W.C, and A.D.C. were supported by CRUK Scotland Institute core funding A17196, A31287 - awarded to O.J.S. J.P.M. was supported by CRUK Beatson Institute core funding A17196, A31287 and A29996.; Najumudeen , A K , Fey , S K , Millett , L M , Ford , C A , Gilroy , K , Gunduz , N , Ridgway , R A , Anderson , E , Strathdee , D , Clark , W , Nixon , C , Morton , J P , Campbell , A D & Sansom , O J 2024 , ' KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo ' , Nature Communications , vol. 15 , 100 . https://doi.org/10.1038/s41467-023-44342-4Test; ORCID: /0000-0002-3764-5721/work/156153324; http://hdl.handle.net/10138/573576Test; 463dd991-3772-4050-bf9d-85cbac1125d4; 001142794000895

الإتاحة: http://hdl.handle.net/10138/573576Test

المؤلفون: Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/320795/1/320795.pdfTest; Malla, S. B. et al. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics , 56(3), pp. 458-472. (doi:10.1038/s41588-024-01654-5 ) (PMID:38351382)

الإتاحة: https://doi.org/10.1038/s41588-024-01654-5Test
https://eprints.gla.ac.uk/320795Test/
https://eprints.gla.ac.uk/320795/1/320795.pdfTest

المؤلفون: Holt, Amy K., Najumudeen, Arafath K., Collard, Tracey J., Li, Hao, Millett, Laura M., Hoskin, Ashley J., Legge, Danny N., Mortensson, Eleanor M. H., Flanagan, Dustin J., Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D., Cronin, James, Sansom, Owen J., Williams, Ann C., Vincent, Emma E.

المساهمون: Institute of Biotechnology, Kidney development, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Aspirin, Cb-839, Colorectal cancer, Glutaminase, Metabolic reprogramming, Metabolism, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: AKH and AJH were supported by the James Tudor Foundation; AKH, AJH and EMHM were supported by John and Bridget Maynard; and PT was supported by a PhD studentship from Bowel & Cancer Research. AKH, AJH, EMHM and PT were also supported by the John James Bristol Foundation. DF, TJC, OJS and ACW by an MRC Research Grant (MR/R017247/1). EEV and DNL are supported by Diabetes UK (17/0005587) and the World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme (IIG_2019_2009). EEV and TJC are supported by the Cancer Research UK (CRUK) Integrative Cancer Epidemiology Programme (C18281/A29019). AKN was supported by Cancer Research UK (CRUK) Beatson Institute core funding (A17196, A31287)-awarded to OJS. OJS was supported by CRUK grants (A21139, A12481, A17196 and A31287) and ERC Starting grant (311301). LMM is supported by a CRUK Scotland Centre Grant (CTRQQR-2021\100006).; Holt , A K , Najumudeen , A K , Collard , T J , Li , H , Millett , L M , Hoskin , A J , Legge , D N , Mortensson , E M H , Flanagan , D J , Jones , N , Kollareddy , M , Timms , P , Hitchings , M D , Cronin , J , Sansom , O J , Williams , A C & Vincent , E E 2023 , ' Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition ' , Cancer & Metabolism , vol. 11 , 18 . https://doi.org/10.1186/s40170-023-00318-yTest; 79183b88-6bce-46f8-be9f-33f80fb83f77; http://hdl.handle.net/10138/568723Test; 001097431700001

الإتاحة: http://hdl.handle.net/10138/568723Test

المؤلفون: Vande Voorde, Johan, Steven, Rory T., Najumudeen, Arafath K., Ford, Catriona A., Dexter, Alex, Gonzalez-Fernandez, Ariadna, Nikula, Chelsea J., Xiang, Yuchen, Ford, Lauren, Maneta Stavrakaki, Stefania, Gilroy, Kathryn, Zeiger, Lucas B., Pennel, Kathryn, Hatthakarnkul, Phimmada, Elia, Efstathios A., Nasif, Ammar, Murta, Teresa, Manoli, Eftychios, Mason, Sam, Gillespie, Michael, Lannagan, Tamsin R.M., Vlahov, Nikola, Ridgway, Rachel, Nixon, Colin, Raven, Alexander, Mills, Megan, Athineos, Dimitris, Kanellos, Georgios, Nourse, Craig, Gay, David M., Hughes, Mark, Burton, Amy, Yan, Bin, Sellers, Katherine, Wu, Vincen, De Ridder, Kobe, Shokry, Engy, Huerta Uribe, Alejandro, Clark, William, Clark, Graeme, Kirschner, Kristina, Thienpont, Bernard, Li, Vivian S.W., Maddocks, Oliver D.K., Barry, Simon T., Goodwin, Richard J.A., Kinross, James, Edwards, Joanne, Yuneva, Mariia O., Sumpton, David, Takats, Zoltan, Campbell, Andrew D., Bunch, Josephine, Sansom, Owen J.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/303421/1/303421.pdfTest; Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism , 5(8), pp. 1303-1318. (doi:10.1038/s42255-023-00857-0 ) (PMID:37580540) (PMCID:PMC10447251)

الإتاحة: https://doi.org/10.1038/s42255-023-00857-0Test
https://eprints.gla.ac.uk/303421Test/
https://eprints.gla.ac.uk/303421/1/303421.pdfTest

المؤلفون: Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valérie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petros, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

المساهمون: Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valérie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petro, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

مصطلحات موضوعية: cell plasticity, colorectal cancer, colorectal neoplasia, intestinal polyp, intestinal stem cell, molecular phenotyping, stem cell, Animal, Homeostasi, Human, Intestine, Mice, Neoplastic Stem Cell, Receptors, G-Protein-Coupled, Colorectal Neoplasm, Intestinal Mucosa

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35931031; info:eu-repo/semantics/altIdentifier/wos/WOS:000843892000007; volume:29; issue:8; firstpage:1213; lastpage:1228; numberofpages:16; journal:CELL STEM CELL; https://hdl.handle.net/2318/1880629Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135464912

الإتاحة: https://doi.org/10.1016/j.stem.2022.07.008Test
https://hdl.handle.net/2318/1880629Test

المؤلفون: Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.

المصدر: Cell Stem Cell ; volume 29, issue 11, page 1612 ; ISSN 1934-5909

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Medicine

الإتاحة: https://doi.org/10.1016/j.stem.2022.09.005Test
https://api.elsevier.com/content/article/PII:S1934590922003824?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1934590922003824?httpAccept=text/plainTest

المؤلفون: Knight, John R.P., Alexandrou, Constantinos, Skalka, George L., Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M., May-Wilson, Sebastian, Smith, Ewan M., Najumudeen, Arafath K., Gilroy, Kathryn, Ridgway, Rachel A., Flanagan, Dustin J., Smith, Rachael C.L., McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D., Jackstadt, Rene, Waldron, Joseph A., Campbell, Andrew D., Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M., Sonenberg, Nahum, Proud, Christopher G., Jones, Neil P., Swarbrick, Martin E., McKinnon, Heather J., Faller, William J., Quesne, John Le, Edwards, Joanne, Willis, Anne E., Bushell, Martin, Sansom, Owen J.

المصدر: Knight , J R P , Alexandrou , C , Skalka , G L , Vlahov , N , Pennel , K , Officer , L , Teodosio , A , Kanellos , G , Gay , D M , May-Wilson , S , Smith , E M , Najumudeen , A K , Gilroy , K , Ridgway , R A , Flanagan , D J , Smith , R C L , McDonald , L , MacKay , C , Cheasty , A , McArthur , K , Stanway , E , Leach , J D , ....

مصطلحات موضوعية: Animals, Colorectal Neoplasms/genetics, Disease Models, Animal, Eukaryotic Initiation Factor-4E/drug effects, Humans, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mice, Inbred C57BL, Phosphorylation, Protein Serine-Threonine Kinases/drug effects, ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre

العلاقة: https://research.manchester.ac.uk/en/publications/e2b9afde-dfcb-40fe-b3a3-ece044a73148Test

الإتاحة: https://doi.org/10.1158/2159-8290.CD-20-0652Test
https://research.manchester.ac.uk/en/publications/e2b9afde-dfcb-40fe-b3a3-ece044a73148Test

المؤلفون: Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean Paul, Katajisto, Pekka, Sansom, Owen J.

المساهمون: Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory

مصطلحات موضوعية: STEM-CELLS, BETA-CATENIN, BONE-FORMATION, WNT, MUTATION, HOMEOSTASIS, ACTIVATION, INTESTINE, POLYPOSIS, PATHWAY, 1182 Biochemistry, cell and molecular biology, 3122 Cancers

وصف الملف: application/pdf

العلاقة: Acknowledgements We thank the Core Services and Advanced Technologies at the Cancer Research UK Beatson Institute (C596/A17196 and A31287), and particularly the Biological Services Unit, Histology Service and Molecular Technologies; members of the Sansom and Katajisto laboratories for discussions of the data and manuscript; and BRC Oxford for supplying patient material. O.J.S. and his laboratory members were supported by Cancer Research UK (A28223, A21139, A12481 and A17196). D.J.F. and M.C.H. were supported by the UK Medical Research Council (MR/R017247/1 and MR/J50032X/1, respectively). SpecifiCancer CRUK Grand Challenge (C7932/A29055) is funded by Cancer Research UK and the Mark Foundation for Cancer Research. P.K. and his laboratory members were supported by the Academy of Finland Centre of Excellence MetaStem (266869, 304591 and 320185), the ERC Starting Grant 677809, the Swedish Research Council 2018-03078, the Cancerfonden 190634, the Jane and Aatos Erkko Foundation and the Cancer Foundation Finland. N.P. was supported by the Finnish Cultural Foundation, the Biomedicum Helsinki Foundation, the Orion Research Foundation sr and The Paulo Foundation. P.V.F. was supported by Alzheimer’s Research UK and The Francis Crick Institute. The ARUK UCL Drug Discovery Institute receives its core funding from Alzheimer’s Research UK (520909). The Francis Crick Institute receives its core funding from Cancer Research UK (FC001002), the UK Medical Research Council (FC001002) and the Wellcome Trust (FC001002).; Flanagan , D J , Pentinmikko , N , Luopajärvi , K , Willis , N J , Gilroy , K , Raven , A P , Mcgarry , L , Englund , J I , Webb , A T , Scharaw , S , Nasreddin , N , Hodder , M C , Ridgway , R A , Minnee , E , Sphyris , N , Gilchrist , E , Najumudeen , A K , Romagnolo , B , Perret , C , Williams , A C , Clevers , H , Nummela , P , Lähde , M , Alitalo , K , Hietakangas , V , Hedley , A , Clark , W , Nixon , C , Kirschner , K , Jones , E Y , Ristimäki , A , Leedham , S J , Fish , P V , Vincent , J P , Katajisto , P & Sansom , O J 2021 , ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ' , Nature , vol. 594 , no. 7863 , pp. 430-435 . https://doi.org/10.1038/s41586-021-03525-zTest , https://doi.org/10.1038/s41586-021-03525-zTest; ORCID: /0000-0001-9637-6843/work/97056080; ORCID: /0000-0002-3764-5721/work/124844611; ORCID: /0000-0002-2768-8816/work/125976777; 85107302159; 0d60f233-972d-476c-b6db-817ae967b4bb; http://hdl.handle.net/10138/337493Test; 000657239300001

الإتاحة: http://hdl.handle.net/10138/337493Test

المؤلفون: Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, Maughan, Tim, Salto-Tellez, Manuel, Quirke, Philip, Koelzer, Viktor, Dunne, Philip, Beggs, Andrew, Campbell, Peter, Buffa, Francesca, Holmes, Chris, Kaplan, Rick, Brown, Louise, Lawler, Mark, Hordern, Joshua, Tomlinson, Ian, Leedham, Simon, Morton, Dion, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.

المصدر: ISSN: 2041-1723 ; Nature communications, vol. 12, no. 1 (2021) 3464.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34103493; info:eu-repo/semantics/dataset/url/https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE168478Test; info:eu-repo/grantAgreement/EC/FP7/311301/EU/Targeting downstream effectors of Wnt signaling in colorectal cancer/COLONCAN; info:eu-repo/grantAgreement/EC/H2020/659666/EU/Characterization of Intestinal Cancer Cell Invasion/CICCI; https://archive-ouverte.unige.ch/unige:161332Test; unige:161332

الإتاحة: https://doi.org/10.1038/s41467-021-23717-5Test
https://archive-ouverte.unige.ch/unige:161332Test

المؤلفون: Leach, Joshua D.G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret, Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J., Maughan, Tim, Salto-Tellez, Manuel, Quirke, Philip, Koelzer, Viktor, Dunne, Philip, Beggs, Andrew, Campbell, Peter, Buffa, Francesca, Holmes, Chris, Kaplan, Rick, Brown, Louise, Lawler, Mark, Hordern, Joshua, Tomlinson, Ian, Leedham, Simon, Morton, Dion

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/243747/1/243747.pdfTest; Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications , 12, 3464. (doi:10.1038/s41467-021-23717-5 ) (PMID:34103493) (PMCID:PMC8187652)

الإتاحة: https://doi.org/10.1038/s41467-021-23717-5Test
https://eprints.gla.ac.uk/243747Test/
https://eprints.gla.ac.uk/243747/1/243747.pdfTest