المؤلفون: Maria M. Disotuar, Jake A. Smith, Jinze Li, Steve Alam, Nai-Pin Lin, Danny Hung-Chieh Chou

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)

مصطلحات موضوعية: Diabetes mellitus, Insulin synthesis, Sortase A (SrtA) ligation, Albumin-binding peptide SA21, Long-acting insulin, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211383520308017Test; https://doaj.org/toc/2211-3835Test

الوصول الحر: https://doaj.org/article/e9bbce0b22c74cc1b83327e6a696433aTest

المؤلفون: Nai-Pin Lin, Nan Zheng, Landa Purushottam, Yi Wolf Zhang, Danny Hung-Chieh Chou

المصدر: Frontiers in Chemistry, Vol 10 (2022)

مصطلحات موضوعية: insulin, glucose responsiveness, peptide, insulin modification, phenylboronate, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fchem.2022.859133/fullTest; https://doaj.org/toc/2296-2646Test

الوصول الحر: https://doaj.org/article/22cb8c0690774d3f9270ef7e8ec302b6Test

المؤلفون: Yi Wolf Zhang, Nai-Pin Lin, Xu Guo, Nicolas Szabo-Fresnais, Peter J. Ortoleva, Danny Hung-Chieh Chou

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Physiology, Biotechnology, Cancer, Virology, Chemical Sciences not elsewhere classified, molecular dynamics studies, approach holds promise, phage piii protein, phage display library, insulin b27 residue, high conversion rate, enhanced therapeutic properties, insulin analogues revealed, insulin engineering chemical, mediated phage display, peptide library modification, novel insulin analogues, insulin analogues, mediated phage, human insulin, throughput engineering, therapeutic compounds, perform high, novel interaction, mediated selective, terminal segments, terminal regions

العلاقة: https://figshare.com/articles/journal_contribution/Omniligase-1-Mediated_Phage-Peptide_Library_Modification_and_Insulin_Engineering/25057471Test

الإتاحة: https://doi.org/10.1021/acschembio.3c00685.s001Test
https://figshare.com/articles/journal_contribution/Omniligase-1-Mediated_Phage-Peptide_Library_Modification_and_Insulin_Engineering/25057471Test

المؤلفون: Claire Park, Yanxian Zhang, Jae Un Jung, Line Due Buron, Nai-Pin Lin, Thomas Hoeg-Jensen, Danny Hung-Chieh Chou

المصدر: Journal of Medicinal Chemistry.

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4a9be9b17cf4f07662d32261e4d641Test
https://doi.org/10.1021/acs.jmedchem.3c00280Test

المؤلفون: Jinze Li, Maria M. Disotuar, Nai-Pin Lin, Jake A. Smith, Danny Hung-Chieh Chou, Steve L. Alam

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Alb, albumin, Insulin degludec, pAkt, phosphorylated protein kinase B, Boc, tert-butyloxycarbonyl, medicine.medical_treatment, Lysine, DMSO, dimethyl sulfoxide, EDT, 1,2-ethanedithiol, 0302 clinical medicine, Diabetes mellitus, HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, NBD-X, 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoic acid, t-Bu, tert-butyl, General Pharmacology, Toxicology and Pharmaceutics, HTRF, homogeneous time resolved fluorescence, Mtt, 4-methyltrityl, Insulin detemir, Long-acting insulin, 0303 health sciences, Chemistry, Albumin-binding peptide SA21, i.p., intraperitoneal, Therapeutic Insulin, DCM, dichloromethane, Biochemistry, HPLC, high performance liquid chromatography, 030220 oncology & carcinogenesis, Sortase A, DMF, dimethylformamide, Fmoc, 9-fluorenylmethoxycarbonyl, medicine.drug, DOI, desoctapeptide (B23−30) insulin, Short Communication, RM1-950, DMEM, Dulbecco's Modified Eagle Medium, STZ, streptozotocin, TIS, triisoproylsilane, 03 medical and health sciences, FBS, fetal bovine serum, Insulin synthesis, medicine, ITT, insulin tolerance test, 030304 developmental biology, Insulin, THF, triflouroacetic acid, HBTU, O-(benxontriazol-1-yl)-1,1,3,3-tetramethyluronium, Sortase A (SrtA) ligation, medicine.disease, IR-B, human insulin receptor isoform B, LC‒MS, liquid chromatography mass spectrometry, DIEA, N,N-diisopropylethylamine, Therapeutics. Pharmacology, Ligation, SrtA, sortase A

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1984559319e185f56741a54626eb56Test
http://www.sciencedirect.com/science/article/pii/S2211383520308017Test

المؤلفون: Nai-Pin Lin, Danny Hung-Chieh Chou

المصدر: Science (New York, N.Y.). 376(6599)

مصطلحات موضوعية: Multidisciplinary, Biocatalysis, Humans, Insulin, Penicillin Amidase, Protein Engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1add41902bb160a086eca846a14bbfTest
https://pubmed.ncbi.nlm.nih.gov/35709255Test

المؤلفون: Nai-Pin Lin, Danny Hung-Chieh Chou, Yi Zhang, Nicolas Szabo-Fresnais

مصطلحات موضوعية: chemistry.chemical_classification, Phage display, biology, Chemistry, Insulin, medicine.medical_treatment, Insulin analog, Peptide, Insulin receptor, Biochemistry, Ectodomain, medicine, biology.protein, Ligation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208e0721fca21d13972d8c28a0c7f486Test
https://doi.org/10.26434/chemrxiv-2021-mf3bsTest

المؤلفون: Rong-Jie Chein, Nai-Pin Lin

المصدر: Organic & Biomolecular Chemistry. 18:8899-8907

مصطلحات موضوعية: Trigonella, biology, Chemistry, Stereochemistry, Organic Chemistry, Type 2 Diabetes Mellitus, Total synthesis, biology.organism_classification, Biochemistry, Absolute structure, chemistry.chemical_compound, Glucagon-Like Peptide 1, Yield (chemistry), Amide, Physical and Theoretical Chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561bc04f0d7901b60f285d34c757c223Test
https://doi.org/10.1039/d0ob01722aTest

المؤلفون: Nai-Pin Lin, Nan Zheng, Landa Purushottam, Yi Wolf Zhang, Danny Hung-Chieh Chou

مصطلحات موضوعية: Biochemistry, Environmental Chemistry, Geochemistry, Organic Chemistry, Inorganic Chemistry, Nuclear Chemistry, Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics), Medical Biochemistry and Metabolomics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Analytical Biochemistry, Cell Neurochemistry, Enzymes, Electroanalytical Chemistry, Analytical Chemistry not elsewhere classified, Organic Green Chemistry, Physical Organic Chemistry, Catalysis and Mechanisms of Reactions, Environmental Chemistry (incl. Atmospheric Chemistry), insulin, glucose responsiveness, peptide, insulin modification, phenylboronate

العلاقة: https://figshare.com/articles/dataset/DataSheet1_Synthesis_and_Characterization_of_Phenylboronic_Acid-Modified_Insulin_With_Glucose-Dependent_Solubility_docx/19365839Test

الإتاحة: https://doi.org/10.3389/fchem.2022.859133.s001Test
https://figshare.com/articles/dataset/DataSheet1_Synthesis_and_Characterization_of_Phenylboronic_Acid-Modified_Insulin_With_Glucose-Dependent_Solubility_docx/19365839Test

المؤلفون: Nai-Pin Lin, Thomas Jin-Chee Liu

المصدر: Journal of the Institute of Industrial Applications Engineers. 6:156-164

مصطلحات موضوعية: Snap through, Material type, Materials science, business.industry, Indentation, Product (mathematics), Shell (structure), Working temperature, Structural engineering, Arch, business, Finite element method

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::04c62c0c3d7c1f027e55ea35b6a10420Test
https://doi.org/10.12792/jiiae.6.156Test