دورية أكاديمية
Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis
| العنوان: | Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
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| المؤلفون: | Nagase, Chihiro, Tanno, Masaya, Kouzu, Hidemichi, Miki, Takayuki, Nishida, Junichi, Murakami, Naoto, Kokubu, Nobuaki, Nagano, Nobutaka, Nishikawa, Ryo, Yoshioka, Nobuhiro, Hasegawa, Tohru, Kita, Hiroyuki, Tsuchida, Akihito, Ohnishi, Hirofumi, Miura, Tetsuji |
| المساهمون: | Investigator-Initiated Studies Program of Merck Sharp & Dohme Corp. / MSD K.K. |
| المصدر: | Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent of coronary artery stenosis in non-diabetic patients. Non-diabetic patients who were admitted for coronary angiography without a history of coronary interventions were enrolled. Coronary artery stenosis was quantified by Gensini score (GS), and GS ≥ 10 was used as an outcome variable based on its predictive value for cardiovascular events. The patients (mean age, 66.5 ± 8.8 years; 71% males, n = 173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active GLP-1 levels. The area under the curve of plasma active GLP-1 (AUC-GLP-1) was determined as an index of GLP-1 secretory capacity. AUC-GLP-1 was not correlated with fasting glucose, AUC-glucose, serum lipids or indices of insulin sensitivity. In multivariate logistic regression analysis for GS ≥ 10, AUC-GLP-1 < median, age and hypertension were selected as explanatory variables, though fasting GLP-1 level was not selected. The findings suggest that reduction in GLP-1 secretory capacity is a novel independent risk factor of coronary stenosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-021-95065-9 |
| الإتاحة: | https://doi.org/10.1038/s41598-021-95065-9Test https://www.nature.com/articles/s41598-021-95065-9.pdfTest https://www.nature.com/articles/s41598-021-95065-9Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.F74C018F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-95065-9 |
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