دورية أكاديمية
Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers
| العنوان: | Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers |
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| المؤلفون: | Nadin Rabah, Fatima-Ezzahra Ait Mohand, Nataly Kravchenko-Balasha |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 18, p 14256 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | glioblastoma, recurrence, heterogeneity, invasion, blood–brain barrier (BBB), targeted therapy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The most prevalent and aggressive type of brain cancer, namely, glioblastoma (GBM), is characterized by intra- and inter-tumor heterogeneity and strong spreading capacity, which makes treatment ineffective. A true therapeutic answer is still in its infancy despite various studies that have made significant progress toward understanding the mechanisms behind GBM recurrence and its resistance. The primary causes of GBM recurrence are attributed to the heterogeneity and diffusive nature; therefore, monitoring the tumor’s heterogeneity and spreading may offer a set of therapeutic targets that could improve the clinical management of GBM and prevent tumor relapse. Additionally, the blood–brain barrier (BBB)-related poor drug delivery that prevents effective drug concentrations within the tumor is discussed. With a primary emphasis on signaling heterogeneity, tumor infiltration, and computational modeling of GBM, this review covers typical therapeutic difficulties and factors contributing to drug resistance development and discusses potential therapeutic approaches. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/24/18/14256Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms241814256 |
| الوصول الحر: | https://doaj.org/article/3866ec1046da433a90da9fae6383ef7fTest |
| رقم الانضمام: | edsdoj.3866ec1046da433a90da9fae6383ef7f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms241814256 |