المؤلفون: Pavlina Spiliopoulou, Farasat Kazmi, Francesca Aroldi, Thomas Holmes, David Thompson, Lucinda Griffiths, Cathy Qi, Matthew Parkes, Simon Lord, Gareth J. Veal, David J. Harrison, Vicky M. Coyle, Jill Graham, Thomas R. Jeffry Evans, Sarah P. Blagden

المصدر: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: NUC-3373, 5-FU, 5-fluorouracil, Fluoropyrimidines, Thymidylate synthase, Resistant cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1756-9966Test

الوصول الحر: https://doaj.org/article/8de199adb6da4ff4b44e74190f835493Test

المؤلفون: Spiliopoulou, Pavlina, Kazmi, Farasat, Aroldi, Francesca, Holmes, Thomas, Thompson, David, Griffiths, Lucinda, Qi, Cathy, Parkes, Matthew, Lord, Simon, Veal, Gareth J., Harrison, David J., Coyle, Vicky M., Graham, Jill, Jeffry Evans, Thomas R., Blagden, Sarah P.

المصدر: Spiliopoulou , P , Kazmi , F , Aroldi , F , Holmes , T , Thompson , D , Griffiths , L , Qi , C , Parkes , M , Lord , S , Veal , G J , Harrison , D J , Coyle , V M , Graham , J , Jeffry Evans , T R & Blagden , S P 2024 , ' A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301) ' , Journal of Experimental & Clinical Cancer Research , vol. 43 ....

مصطلحات موضوعية: NUC-3373, 5-FU, 5-fluorouracil, Fluoropyrimidines, Thymidylate synthase, Resistant cancer

وصف الملف: application/pdf

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/a-phase-i-openlabel-doseescalation-study-of-nuc3373-a-targeted-thymidylate-synthase-inhibitor-in-patients-with-advanced-cancer-nutide301Test(27ec498d-bc27-4d39-87d8-b4103dff84ba).html

الإتاحة: https://doi.org/10.1186/s13046-024-03010-1Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/a-phase-i-openlabel-doseescalation-study-of-nuc3373-a-targeted-thymidylate-synthase-inhibitor-in-patients-with-advanced-cancer-nutide301Test(27ec498d-bc27-4d39-87d8-b4103dff84ba).html
https://research-repository.st-andrews.ac.uk/bitstream/10023/29592/1/Spiliopoulou_2024_JECCR_Phase-I-open-label_CC.pdfTest

المؤلفون: Bré, Jennifer L., Dickson, Alison, Read, Oliver J., Zhang, Ying, McKissock, Fiona G., Mullen, Peter, Tang, Peijun, Zickuhr, Greice M., Melo Czekster, Clarissa, Harrison, David J.

المصدر: Bré , J L , Dickson , A , Read , O J , Zhang , Y , McKissock , F G , Mullen , P , Tang , P , Zickuhr , G M , Melo Czekster , C & Harrison , D J 2023 , ' The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent ' , Cancer Chemotherapy and Pharmacology . https://doi.org/10.1007/s00280-023-04528-5Test

مصطلحات موضوعية: Fluoropyrimidine, Colorectal cancer, Thymidylate synthase, DNA damage, NUC-3373

وصف الملف: application/pdf

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/the-novel-anticancer-fluoropyrimidine-nuc3373-is-a-potent-inhibitor-of-thymidylate-synthase-and-an-effective-dnadamaging-agentTest(7b22a0e3-d12d-4f65-887c-05908d7d1bbf).html

الإتاحة: https://doi.org/10.1007/s00280-023-04528-5Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/the-novel-anticancer-fluoropyrimidine-nuc3373-is-a-potent-inhibitor-of-thymidylate-synthase-and-an-effective-dnadamaging-agentTest(7b22a0e3-d12d-4f65-887c-05908d7d1bbf).html
https://research-repository.st-andrews.ac.uk/bitstream/10023/27331/1/Bre_2023_CCP_Novel_anti_cancer_CC.pdfTest

المؤلفون: Jennifer Bré, Alison L. Dickson, Oliver J. Read, Ying Zhang, Fiona G. McKissock, Peter Mullen, Peijun Tang, Greice M. Zickuhr, Clarissa M. Czekster, David J. Harrison

المساهمون: Innovate UK, University of St Andrews. School of Biology, University of St Andrews. School of Medicine, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division

المصدر: Cancer Chemotherapy and Pharmacology. 91:401-412

مصطلحات موضوعية: MCC, Pharmacology, Cancer Research, RC0254 Neoplasms. Tumors. Oncology (including Cancer), NDAS, Toxicology, Colorectal cancer, RC0254, NUC-3373, SDG 3 - Good Health and Well-being, Oncology, Thymidylate synthase, DNA damage, Pharmacology (medical), Fluoropyrimidine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d806fb950ffd20e09ec9f1c3ba63c442Test
https://doi.org/10.1007/s00280-023-04528-5Test