المؤلفون: Satoko Komatsu-Hirota, Yu-shin Sou, Masaaki Komatsu, Mohammad Omar Faruk, Nobuo N. Noda, Shun Kageyama, Yoshinobu Ichimura, Afnan H. El-Gowily, Masato Koike

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: amyotrophic lateral sclerosis, autophagy, NF-E2-Related Factor 2, Mutant, Mutation, Missense, LIR, LC3-interacting region, Biochemistry, NRF2, PDB, Paget’s disease of bone, Mice, Gene expression, Sequestosome-1 Protein, NQO1, NAD(P)H dehydrogenase, quinone 1, medicine, Missense mutation, Animals, Humans, Amyotrophic lateral sclerosis, BRET, bioluminescence resonance energy transfer, NRF2, nuclear factor erythroid 2–related factor 2, Molecular Biology, Gene, Kelch-Like ECH-Associated Protein 1, Transition (genetics), Chemistry, UBA, ubiquitin-associated, Autophagy, p62, liquid droplet, KIR, Kelch-like ECH-associated protein 1–interacting region, Cell Biology, medicine.disease, ALS, amyotrophic lateral sclerosis, GSTM1, Glutathione S-transferase Mu 1, FTD, frontotemporal degeneration, Cell biology, HEK293 Cells, TRAF6, tumor necrosis factor receptor–associated factor 6, mTORC1, mechanistic target of rapamycin complex 1, UGDH, UDP-glucose 6-dehydrogenase, RBP, RNA-binding protein, Intracellular, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9984bac28fcd074c4fc72342ddc213Test
https://pubmed.ncbi.nlm.nih.gov/34774801Test

المؤلفون: Hongquan Guo, Xinfeng Liu, Juanji Li, Xiaolei Shi, Yi Xie, Pengfei Xu, Yunzi Li, Qian Liu, Rui Sun, Ye Hong, Mengna Peng, Gelin Xu

المصدر: Redox Biology
Redox Biology, Vol 18, Iss, Pp 158-172 (2018)

مصطلحات موضوعية: 0301 basic medicine, BRCT, BRCA1 C-terminal, GPX3, glutathione peroxidase 3, 4-HNE, 4-hydroxynonenol, OGD, oxygen-glucose deprivation, GCLM, glutamate-cysteine ligase regulator subunit, Iba-1, ionized calcium-binding adapter molecule-1, Clinical Biochemistry, SOD1, superoxide dismutase 1, HO-1, heme oxygenase 1, medicine.disease_cause, Biochemistry, NPCs, neural precursor cells, CaMKII, calcium/calmodulin-dependent protein kinase II, Lipid peroxidation, chemistry.chemical_compound, CA1, cornu ammonis 1, NSCs, neural stem cells, 3-NT, 3-nitrotyrosine, XRE, xenobiotic responsive element, skin and connective tissue diseases, lcsh:QH301-705.5, BER, base excision repair, GFP, green fluorescent protein, PSD95, postsynaptic density protein 95, chemistry.chemical_classification, lcsh:R5-920, DCX, doublecortin, ALS, amyotrophic lateral sclerosis, NRF2, nuclear factor (erythroid-derived 2)-like 2, GPX4, glutathione peroxidase 4, 8-OHDG, 8-hydroxy-2′-deoxyguanosine, Signal transduction, lcsh:Medicine (General), Ischemia/Reperfusion, Research Paper, NQO1, NAD(P)H dehydrogenase (quinone 1), DNA damage, DNA repair, Ischemia, I/R, ischemia/reperfusion, CNS, central nervous system, GCLC, glutamate-cysteine ligase catalytic, NRF2, 03 medical and health sciences, ROS, reactive oxygen species, NER, nucleotide excision repair, medicine, MCAO, middle cerebral artery occlusion, SOD2, superoxide dismutase 2, Reactive oxygen species, AD, Alzheimer disease, Organic Chemistry, GFAP, glial fibrillary acidic protein, BRCA1, medicine.disease, ARE, antioxidative response element, 030104 developmental biology, lcsh:Biology (General), chemistry, NHEJ, non-homologous end joining, Oxidative stress, BRCA1, breast cancer susceptibility protein 1, DSBs, double strand breaks, Cancer research, HR, homologous recombination, Reperfusion injury

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e034e7c5102b1e7cd98f372f511aacTest
https://doi.org/10.1016/j.redox.2018.06.012Test

المؤلفون: Masaaki Komatsu, Junya Sango, Masahiko Takahashi, Sergei Anisimov, Yoshinori Katsuragi, Masahiro Fujii, Taichi Kakihana

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Antioxidant, Dopamine, Parkinson's disease, medicine.medical_treatment, Apoptosis, PD, Parkinson's disease, environment and public health, Biochemistry, Antioxidants, HO-1, heme oxygenase-1, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, DMEM, Dulbecco's modified Eagle's medium, p62, Dopaminergic, HRP, horseradish peroxidase, Parkinson Disease, ROS, respiratory system, Cell biology, NQO1, NAD(P)H dehydrogenase quinone 1, Ubiquitin Thiolesterase, Research Article, medicine.drug, Keap1, SDS, sodium dodecyl sulfate, NF-E2-Related Factor 2, Oxidative phosphorylation, digestive system, Nrf2, Nrf2, nuclear factor erythroid 2–related factor, ROS, reactive oxygen species, FBS, fetal bovine serum, medicine, Humans, Molecular Biology, Reactive oxygen species, USP10, ubiquitin-specific protease 10, Activator (genetics), Dopaminergic Neurons, USP10, Cell Biology, KEAP1, Oxidative Stress, chemistry, siRNA, small interfering RNA, Reactive Oxygen Species, RPS, ribosomal protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf33e254bcf0fe1d306cd534b9fcf583Test
https://doi.org/10.1016/j.jbc.2021.101448Test

المؤلفون: Martina Poturnajova, Zuzana Kozovska, Miroslava Matuskova

المصدر: Cellular Signalling

مصطلحات موضوعية: SMAD4, Mothers against decapentaplegic homolog 4, TLX-1, T-cell leukemia homeobox protein 1, Bcl-2, B-cell lymphoma 2, apoptosis regulator, PPARβ/δ, Peroxisome-proliferator-activated receptor β/δ, Retinoic acid, Aldehyde dehydrogenase, NSPc1, Polycomb 1 of the nervous system, Transcriptional control, TGF- β, Transforming growth factor beta, DHT, Dihydrotestosterone, BRD4, bromodomain-containing protein 4, chemistry.chemical_compound, SRC, proto-oncogene tyrosine-protein kinase, MDR, multidrug resistance, RARRES1, Retinoic acid receptor responder 1, Neoplasms, EZH2, Enhancer of zeste homolog 2, HPCs, hematopoietic progenitors, MEK, Mitogen-activated protein kinase, Transcriptional regulation, Protein Isoforms, RAR, Retinoic acid receptor, cMET (HGFR), Hepatocyte growth factor receptor, TNBC, triple negative breast cancer, biology, Chemistry, HOX, Homeobox protein, ERK, Extracellular signal-regulated kinase, NFκB, Nuclear factor kappa-light-chain-enhancer of activated B cells, Stem cells marker, NANOG, homeobox protein, transcriptional factor, C/EBPβ, CCAAT/enhancer-binding protein β, HNSCC, Head and neck squamous Cancer, Aldehyde Oxidoreductases, Graphical Review, PCAF, acetyltransferase P300/CBP-associated factor, ER, Estrogen receptor, Cell biology, MMP, matrix metalloproteinase, Crosstalk (biology), Molecular regulation, S1P, Sphingosine-1-phosphate, IL-6, Interleukin 6, NRF2, Nuclear respiratory factor 1, SOX2, SRY (sex determining region Y)-box 2, Stem cell, EMT, epithelial-mesenchymal transition, SIRT2, Sirtuin 2, CD24, signal transducer 24, sialoglycoprotein, Gene isoform, atRA, all trans retinoic acid, GADD153, Growth arrest and DNA damage 153, SNAI2, (Slug) zinc finger protein 2, MUC1-C, Mucin 1 glycoprotein, subunit C, Tretinoin, CDK2, Cyclin- dependent kinase 2, CHOP, C/EBP homologous protein, PI3K, Phosphatidylinositol 3-kinase, Aldehyde Dehydrogenase 1 Family, CD44, homing cell adhesion molecule, BAX, Bcl-2-like protein 4, apoptosis regulator, TCF4 (TCF7L2), Transcription factor 7-like 2, HSP27, heat shock protein 27, ROS, reactive oxygen species, RA, Retinoic acid, Humans, BET, bromodomain and extraterminal protein family, RARE, RA responsive element, SNAI1, (Snail) zinc finger protein 1, DANCR (KIAA0114), Differentiation antagonizing non-protein coding RNA, PTEN, Phosphatase and tensin homolog, ALDH1A13, aldehyde dehydrogenase 1 isoforms A1, A3, Mechanism (biology), Retinal Dehydrogenase, mTOR, Mammalian target of rapamycin, RXR, Retinoid X receptor, Cell Biology, HGF, Hepatocyte growth factor, CSC, cancer stem cell, NQO1, NAD(P)H dehydrogenase [quinone] 1, STAT3, Signal transducer and activator of transcription 3, ALDH1A1, CD31, Platelet endothelial cell adhesion molecule 1, RD16, retinol dehydrogenase 16, DDIT3, DNA damage inducible transcript 3, NRAD1 (LINC00284), Non-coding RNA in the aldehyde dehydrogenase 1A pathway, biology.protein, AR, androgen receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1457905c555ffd74710c72192f7cc6ceTest
https://doi.org/10.1016/j.cellsig.2021.110120Test

المؤلفون: Barry Shaw, Sarah L. Rea, Robert Layfield, Mark S. Searle, Alice Goode, Melanie Sultana

المصدر: Molecular and Cellular Neurosciences

مصطلحات موضوعية: 0301 basic medicine, SQSTM1/p62, LIR, LC3-interacting region, ARE, Antioxidant response element, mTORC1, ALS, Amyotrophic lateral sclerosis, PDB, Paget's disease of bone, SALS, Sporadic ALS, Sequestosome-1 Protein, Genetics, Kelch-Like ECH-Associated Protein 1, Nrf2, Nuclear erythroid 2-related factor 2, FTLD, Frontotemporal lobar degeneration, IKKβ, Inhibitor of nuclear factor kappa-B kinase subunit beta, 3. Good health, Keap1, Kelch-like ECH-associated protein 1, Signal transduction, Protein Binding, Signal Transduction, ALS-FTLD, RBM45, RNA binding motif protein 45, NF-E2-Related Factor 2, NQO1, NAD(P)H dehydrogenase, Quinone 1, Mutation, Missense, Repressor, NFE2L2, Nuclear factor erythroid 2-like 2, UBA, Ubiquitin-associated (domain), Biology, Response Elements, Article, SOD1, Superoxide dismutase 1, 03 medical and health sciences, Cellular and Molecular Neuroscience, Humans, KIR, Keap1-interacting region, Gene, Transcription factor, Molecular Biology, Binding Sites, Amyotrophic Lateral Sclerosis, HEK 293 cells, Cell Biology, mTORC1, Mammalian target of rapamycin complex 1, KEAP1, HEK293 Cells, 030104 developmental biology, Oxidative stress, SQSTM1/p62, Sequestosome 1/p62 protein, Keap1-Nrf2, TDP-43, TAR DNA-binding protein 43, Frontotemporal Lobar Degeneration

وصف الملف: application/pdf; PDF

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b99ab77fea0c84b74904df9fba54b47Test

المؤلفون: Julia Yue Cui, Shinhee Park, Sunny Lihua Cheng

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 475-491 (2016)

مصطلحات موضوعية: 0301 basic medicine, Peroxisome proliferator-activated receptor, Aldehyde dehydrogenase, Pharmacology, 030226 pharmacology & pharmacy, H3, Histone 3, Nrf2, nuclear factor erythroid 2-related factor 2, ddCq, delta delta Cq, PVDF, polyvinylidene difluoride, Mice, 0302 clinical medicine, Gst, glutathione S-trasnferase, PBST, phosphate-buffered saline with 0.05% tween 20, CITCO, 6-(4-chlorophenyl)imidazo [2,1-b](1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime, Constitutive androstane receptor, Oatp, organic anion transporting polypeptide (solute carrier organic anion transporter family member), General Pharmacology, Toxicology and Pharmaceutics, hCAR, human constitutive androstane receptor, chemistry.chemical_classification, HRP, horseradish peroxidase, DPGs, drug-processing genes (genes that encodes drug metabolizing enzymes or transporters), ST buffer, sucrose Tris buffer, 3. Good health, Cell biology, Intestine, CAR, Cyp, cytochrome P450, Transporters, medicine.anatomical_structure, Cq, quantification cycle, qPCR, quantitative polymerase chain reaction, Original Article, Nqo1, NAD(P)H dehydrogenase quinone 1, CAR, constitutive androstane receptor, Mrp, multi-drug resistance-associated protein (ABC transporter family C member), Drug-metabolizing enzymes, PBS, phosphate-buffered saline, PPARα, peroxisome proliferator activated receptor alpha, Biology, GSTA4, 03 medical and health sciences, cDNA, complementary DNA, medicine, Messenger RNA, lcsh:RM1-950, Transporter, Drug-processing genes, Papss2, 3ʹ-phosphoadenosine 5ʹ-phosphosulfate synthase 2, WT, wild-type, Small intestine, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, chemistry, TCPOBOP, 3,3ʹ,5,5ʹ-tetrachloro-1,4-bis(pyridyloxy)benzene, Duodenum, biology.protein, Ugt, UDP glucuronosyltransferase, Aldh, aldehyde dehydrogenase, human activities, Sult, sulfotransferase, Asbt, solute carrier family 10, member 2 (apical sodium/bile acid cotransporter)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f228bc5a87c2c28e40433b38832e9981Test

المؤلفون: Maria Dominguez, Issidora S. Papassideri, Aimilia D. Sklirou, Marianna Ralli, Ioannis P. Trougakos, Alexios-Leandros Skaltsounis

المصدر: Redox Biology
Redox Biology, Vol 5, Iss, Pp 205-215 (2015)

مصطلحات موضوعية: Antioxidant responses, Sqstm1, sequestosome 1, Clinical Biochemistry, Cell, PDR, proteome damage responses, Chaperone, hdac6, histone deacetylase 6, Biochemistry, Antioxidants, Cell Movement, hsf1, heat shock transcription factor-1, lcsh:QH301-705.5, Cellular Senescence, lcsh:R5-920, BECN1, Keap1, Kelch-like ECH-associated protein 1, medicine.anatomical_structure, ctsd, cathepsin-D, HDFs, human diploid fibroblasts, Matrix Metalloproteinase 9, Nqo1, NAD(P)H dehydrogenase, quinone 1, Matrix Metalloproteinase 2, lcsh:Medicine (General), Oligopeptides, Nrf2, NF-E2-related factor 2, Research Paper, ALS, autophagy lysosome system, Senescence, Proteasome Endopeptidase Complex, Cell Survival, NF-E2-Related Factor 2, Human fibroblasts, Biology, Hexapeptide-11, Cell Line, ER, endoplasmic reticulum, ROS, reactive oxygen species, UPS, ubiquitin proteasome system, Extracellular, medicine, Autophagy, CLU, apolipoprotein J/Clusterin, Humans, Viability assay, ctsl, cathepsin-L, Txnrd1, thioredoxin reductase 1, hsp, heat shock protein, Proteasome, Organic Chemistry, PN, proteostasis network, Fibroblasts, KEAP1, Diploidy, Oxidative Stress, Proteostasis, lcsh:Biology (General), becn1, beclin-1, Molecular Chaperones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21d891c4db690600e8c356f78ea8f22Test
https://pubmed.ncbi.nlm.nih.gov/25974626Test

المؤلفون: Adedamola, Olayanju, Ian M, Copple, Holly K, Bryan, George T, Edge, Rowena L, Sison, Min Wei, Wong, Zheng-Quan, Lai, Zhi-Xiu, Lin, Karen, Dunn, Christopher M, Sanderson, Ahmad F, Alghanem, Michael J, Cross, Ewa C, Ellis, Magnus, Ingelman-Sundberg, Hassan Z, Malik, Neil R, Kitteringham, Christopher E, Goldring, B Kevin, Park

المصدر: Free Radical Biology & Medicine

مصطلحات موضوعية: Keap1, Carcinoma, Hepatocellular, NF-E2-Related Factor 2, Blotting, Western, Apoptosis, Gclm, glutamate–cysteine ligase regulatory subunit, Brusatol, Free radicals, Cell defense, Real-Time Polymerase Chain Reaction, digestive system, environment and public health, Nrf2, nuclear factor erythroid 2-related factor 2, Nrf2, RT-qPCR, real-time quantitative PCR, Mice, Autophagy, Brucea, Animals, Humans, Hepatocyte, RNA, Messenger, RNA, Small Interfering, AMC, 7-amino-4-methylcoumarin, Cells, Cultured, DNCB, 2,4-dinitrochlorobenzene, Cell Proliferation, Quassins, Toxicity, Reverse Transcriptase Polymerase Chain Reaction, Liver Neoplasms, Original Contribution, respiratory system, Keap1, Kelch-like ECH-associated protein 1, Chemical stress, Oxidative Stress, Gene Expression Regulation, Hepatocytes, HIF-1α, hypoxia-inducible factor 1α, NEM, N-ethylmaleimide, Nqo1, NAD(P)H dehydrogenase quinone 1, IAA, iodoacetamide, NAPQI, N-acetyl-p-benzoquinone imine, Oxidation-Reduction, CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9(11)dien-28-oate, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::0120eae82a5a66da0ccda5377b1d32a8Test
https://pubmed.ncbi.nlm.nih.gov/25445704Test

المؤلفون: Landmann, H, Proia, D A, He, S, Ogawa, L S, Kramer, F, Beißbarth, T, Grade, M, Gaedcke, J, Ghadimi, M, Moll, U, Dobbelstein, M

المصدر: Cell Death & Disease

مصطلحات موضوعية: Cell Line, Tumor, Humans, Original Article, Antineoplastic Agents, Apoptosis, HSP90 Heat-Shock Proteins, Glucuronosyltransferase, Triazoles, Colorectal Neoplasms, 17-AAG, 17-N-allylamino-17-demethoxygeldanamycin, 17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, CRC, colorectal cancer, FDR, false-discovery rate, HPLC, high-performance liquid chromatography, HSP90, heat-shock protein 90, MIF, migration inhibitory factor, NQO1, NAD(P)H dehydrogenase quinone 1, ROS, reactive oxygen species, RT-PCR, quantitative real-time polymerase chain reaction, UDP, uridine diphosphate, UGT1A, UDP glucuronosyltransferase 1A

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1418fee028c3437ec5a62f50d55a7664Test
http://resolver.sub.uni-goettingen.de/purl?gsTest-1/10891

المؤلفون: Balz Frei, Chuan Li, Wei-Jian Zhang

المصدر: Redox Biology
Redox Biology, Vol 9, Iss C, Pp 104-113 (2016)

مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, Clinical Biochemistry, ICAM-1, intercellular adhesion molecule-1, AP-1, activator protein 1, p38 Mitogen-Activated Protein Kinases, Biochemistry, Antioxidants, NF-κB, chemistry.chemical_compound, 0302 clinical medicine, DCFH-DA, 2′,7′-dichlorofluorescin diacetate, heterocyclic compounds, GCL, glutamate-cysteine ligase, lcsh:QH301-705.5, Nrf2, erythroid 2-related factor 2, HO-1, heme oxygenase-1, lcsh:R5-920, ICAM-1, biology, Cell adhesion molecule, GCLM, Chemistry, NF-kappa B, Oxidants, GCLM, glutamate-cysteine ligase modifier subunit, Cell biology, Heme oxygenase-1, 030220 oncology & carcinogenesis, LPS, lipopolysaccharide, Quercetin, E-selectin, endothelial-leukocyte adhesion molecule-1, lcsh:Medicine (General), HAEC, human aortic endothelial cells, Research Paper, NF-E2-Related Factor 2, PBS, phosphate-buffered saline, TNFα, tumor necrosis factor alpha, Gene Expression Regulation, Enzymologic, Nrf2, 03 medical and health sciences, NF-κB, nuclear factor-kappaB, ROS, reactive oxygen species, FBS, fetal bovine serum, NQO1, NAD(P)H dehydrogenase, quinone 1, E-selectin, Humans, Enzyme inducer, Protein kinase A, Inflammation, p38, p38 mitogen-activated protein kinase, qPCR, real-time quantitative polymerase chain reaction, Organic Chemistry, Endothelial Cells, NFKB1, Atherosclerosis, 030104 developmental biology, lcsh:Biology (General), Gene Expression Regulation, biology.protein, EGCG, epigallocatechin gallate, Cell Adhesion Molecules, GCLC, glutamate-cysteine ligase catalytic subunit

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34740f53c80e872ae52b5dd2bf49b09bTest