التفاصيل البيبلوغرافية
العنوان:
Redox control of cancer cell destruction
المؤلفون:
Hegedűs, Csaba , Kovács, Katalin , Polgár, Zsuzsanna , Regdon, Zsolt , Szabó, Éva , Robaszkiewicz, Agnieszka , Forman, Henry Jay , Martner, Anna , Virág, László
المصدر:
Redox Biology, Vol 16, Iss, Pp 59-74 (2018)
بيانات النشر:
Elsevier, 2018.
سنة النشر:
2018
مصطلحات موضوعية:
PARP1, Poly (ADP-ribose) polymerase 1 , TGFβ, Transforming growth factor beta , GFR, growth factor receptor , NQO1, NAD(P)H:quinone oxidoreductase 1 , DAMP, damage-associated molecular pattern , MAP, mitogen-activated protein , MAPKKK, mitogen-activated protein kinase kinase kinase , NAC, N-acetylcysteine , Free radicals , Review Article , PD-L1, Programmed death-ligand 1 , Nrf2, nuclear factor erythroid 2-related factor 2 , Antioxidants , Her/hER, human Estrogen Receptor , HDC, histamine dihydrochloride , ADCC, antibody-dependent cell-mediated cytotoxicity , ERK, extracellular signal-regulated kinase , HIF-1 α, hypoxia inducible factor 1α , IL-2, Interleukin-2 , DCFH 2', 7'-dichlorodihydrofluorescein , GSH, glutathione , Elméleti orvostudományok , NOS, nitric oxide synthase , AML, acute myeloid leukemia , LPS, Lipopolysaccharide , lcsh:QH301-705.5 , Cancer , FAS, first apoptosis signal , PBMC, Peripheral blood mononuclear cell , MΦ, macrophage , EGF, Epidermal growth factor , lcsh:Medicine (General) , ImC, immaturemyeloid cell , PhGPx, phospholipid hydroperoxide glutathione peroxidase , PDGF, Platelet-derived growth factor , Chemotherapeutics , Antineoplastic Agents , PI3K, Phosphatidylinositol 3-kinase , DDR, DNA damage response , TAMs, tumor-associated macrophages , Humans , ILT, immunoglobulin like transcripts , KIR, killer immunoglobulin-like receptor , DDB, Biphenyl Dimethyl Dicarboxylate , CAF, cancer-associated fibroblast , CLs, cytotoxic lymphocytes , NO, nitric oxide , APE1, apurinic/apyrimidinic endonuclease 1 , TRAIL, TNF-related apoptosis-inducing ligand , TrxR1, thioredoxin reductase 1 , CTL, cytotoxic T lymphocyte , PD1, Programmed cell death protein 1 , ASK-1, apoptosis signal-regulated kinase 1 , HMGB1, high mobility group box 1 , Redox regulation , PK, pyruvate kinase , Reactive Oxygen Species , ADCP, antibody-dependent cancer cell phagocytosis , eNOS, Endothelial NOS , cPLA, cytosolic phospholipase A , GST, Glutathione transferase , NSCLC, Non-Small Cell Lung Cancer , LOOH, lipid hydroperoxide , NFκB, nuclear factor kappa-light-chain-enhancer of activated B cells , VEGF, Vascular endothelial growth factor , ABC transporters, ATP-binding cassette transporters , PEDF, pigment epithelium derived factor , PGE2, Prostaglandin E2 , MHC-I, major histocompatibility complex type I , M-CSF, macrophage colony-stimulating factor , Neoplasms , PDT, Photodynamic therapy , NK, Natural Killer cells , TNF, tumor necrosis factor , lcsh:R5-920 , GPx, glutathione peroxidase , TCR, T cell receptor , Orvostudományok , MnTBAP, Mn(III)tetrakis (4-benzoic acid) porphyrin , Natural killer cells , DCs, dendritic cells , Oxidation-Reduction , Signal Transduction , MDSC, myeloid derived suppressor cell , TLR, Toll-like receptor , CTLA-4, cytotoxic T-lymphocyte-associated protein 4 , EMT, epithelial mesenchymal transition , ER, Endoplasmic reticulum , Cytotoxic lymphocytes , Dox, doxorubicin , CAR-T cells, Chimeric Antigen Receptor T-Cell , SOD, superoxide dismutase , EGFR, Epidermal growth factor receptor , MDR, multiple drug resistance , DUOX, nicotinamide adenine dinucleotide phosphate (NADPH) dual oxidase , nNOS, Neuronal NOS , LPO, lipid peroxidation products , NADPH, nicotinamide adenine dinucleotide phosphate , NCR, natural cytotoxicity receptor , CLL, chronic lymphoid leukemia , Oxidative Stress , NOX, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase , lcsh:Biology (General) , GM-CSF, Granulocyte-macrophage colony-stimulating factor , ETO, etoposide , ONOO-, peroxynitrite
الوصف:
Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and in the numerous cancer-related processes often point in different directions. In this review, we focus on the redox control mechanisms of tumor cell destruction. The review covers the tumor-intrinsic role of oxidants derived from the reduction of oxygen and nitrogen in the control of tumor cell proliferation as well as the roles of oxidants and antioxidant systems in cancer cell death caused by traditional anticancer weapons (chemotherapeutic agents, radiotherapy, photodynamic therapy). Emphasis is also put on the role of oxidants and redox status in the outcome following interactions between cancer cells, cytotoxic lymphocytes and tumor infiltrating macrophages. Keywords: Cancer, Redox regulation, Natural killer cells, Cytotoxic lymphocytes, Chemotherapeutics, Free radicals, Antioxidants
وصف الملف:
application/pdf
اللغة:
English
تدمد:
2213-2317
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::153be7bc8a9501b142b779dbaf4a96d6Test http://www.sciencedirect.com/science/article/pii/S2213231717309424Test
حقوق:
OPEN
رقم الانضمام:
edsair.pmid.dedup....153be7bc8a9501b142b779dbaf4a96d6
قاعدة البيانات:
OpenAIRE
