المؤلفون: Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HFD, high-fat diet, Cys, cysteine, cGAS, cyclic GMP–AMP synthase, Review, Poly: I.C, polyinosinic-polycytidylic acid, SAVI, STING-associated vasculopathy with onset in infancy, Bioinformatics, PPI, protein–protein interface, TRAF6, tumor necrosis factor receptor-associated factor 6, TREX1, three prime repair exonuclease 1, STIM1, stromal interaction molecule 1, 0302 clinical medicine, AA, amino acids, GTP, guanosine triphosphate, MLKL, mixed lineage kinase domain-like protein, ICAM-1, intracellular adhesion molecule 1, Medicine, PDE3B/4, phosphodiesterase-3B/4, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, NF-κB, nuclear factor-kappa B, cGAMP, 2′,3′-cyclic GMP–AMP, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, 0303 health sciences, dsDNA, double-stranded DNA, TFAM, mitochondrial transcription factor A, Fatty liver, Damage-associated molecular patterns, IFNIC, interferon-inducible cells, CTD, C-terminal domain, Mitochondria, Crosstalk (biology), Cardiovascular diseases, SNPs, single nucleotide polymorphisms, 030220 oncology & carcinogenesis, Stimulator of interferon genes, AAD, aortic aneurysm and dissection, MI, myocardial infarction, IFNAR, interferon receptors, ER stress, CVDs, cardiovascular diseases, NASH, nonalcoholic steatohepatitis, Intracellular, CDG, c-di-GMP, NTase, nucleotidyltransferase, ATP, adenosine triphosphate, Ser, serine, mTOR, mammalian target of rapamycin, RM1-950, STING, stimulator of interferon genes, hSTING, human stimulator of interferon genes, AKT, protein kinase B, CDNs, cyclic dinucleotides, TLR, Toll-like receptors, ER, endoplasmic reticulum, 03 medical and health sciences, LBD, ligand-binding pocket, ROS, reactive oxygen species, YAP1, Yes-associated protein 1, IFN, interferon, ISGs, IRF-3-dependent interferon-stimulated genes, DAMPs, danger-associated molecular patterns, IFN-I, type 1 interferon, 030304 developmental biology, Inflammation, Ang II, angiotensin II, TNFα, tumor necrosis factor-alpha, business.industry, IRF3, interferon regulatory factor 3, CTT, C-terminal tail, Autophagy, TAK1, transforming growth factor β-activated kinase 1, Metabolic diseases, medicine.disease, HAQ, R71H-G230A-R293Q, IL, interleukin, mtDNA, mitochondrial DNA, AMPK, AMP-activated protein kinase, Sting, Apoptosis, TBK1, TANK-binding kinase 1, CBD, C-binding domain, LPS, lipopolysaccharides, NO2-FA, nitro-fatty acids, PKA, protein kinase A, NAFLD, nonalcoholic fatty liver disease, Therapeutics. Pharmacology, DsbA-L, disulfide-bond A oxidoreductase-like protein, business, Homeostasis, MST1, mammalian Ste20-like kinases 1, TM, transmembrane, STING, cGAS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf60046ceb32698b7a7ea7c3674b44Test
http://www.sciencedirect.com/science/article/pii/S2211383521001775Test

المؤلفون: Ahmed Elshafei, Emad Gamil Khidr, Maher H. Gomaa, Ahmed A. El-Husseiny

المصدر: Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6465-6470 (2021)
Saudi Journal of Biological Sciences

مصطلحات موضوعية: Coronavirus disease 2019 (COVID-19), QH301-705.5, miR-21, microRNA-21, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ACE2, Review, Disease, CVD, cardiovascular disease, Pharmacology, Lung injury, ACE2, angiotensin-converting enzyme 2, TGF-β, transforming growth factor-beta, ACE1, angiotensin-converting enzyme 1, ACEIs, angiotensin-converting enzyme inhibitors, Ang 1-7, angiotensin 1-7, ERK, extracellular signal-regulated kinase, RAAS, renin-angiotensin-aldosterone system, Fibrosis, Angiotensin 1–7, ARBs, angiotensin receptor blockers, Pulmonary fibrosis, Renin–angiotensin system, medicine, AT2R, angiotensin type 2 receptor, ARBs, Biology (General), COVID-19, coronavirus disease 2019, business.industry, AngII, angiotensin II, NLRP3, (NOD, LRR, and pyrin domain-containing protein 3), Angiotensin II, ACEIs, COVID-19, AngI, angiotensin I, medicine.disease, ICU, intensive care unit, AT1R, angiotensin type 1 receptor, AEC-II, alveolar epithelial type II cells, General Agricultural and Biological Sciences, business, MAPK, mitogen-activated protein kinase, hormones, hormone substitutes, and hormone antagonists, Ang 1-9, angiotensin 1-9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5f9b3141b315ed573222f71db5af3Test
http://www.sciencedirect.com/science/article/pii/S1319562X2100574XTest

المؤلفون: George Giannopoulos, Michael W. Cleman, Theodore G. Papaioannou, Alexandra J. Lansky, Sotiria G. Giotaki, Gerasimos Siasos, Giulio G. Stefanini, Spyridon Deftereos, Jean-Claude Tardif, Konstantinos A. Papathanasiou, Konstantinos Iliodromitis, Dimitrios A. Vrachatis, Bernhard Reimers

المصدر: Toxicology Reports, Vol 8, Iss, Pp 1389-1393 (2021)
Toxicology Reports

مصطلحات موضوعية: Drug, medicine.medical_specialty, 2019-20 coronavirus outbreak, History, Health, Toxicology and Mutagenesis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, CAD, coronary artery disease, Toxicology, CAD - Coronary artery disease, ACS - Acute coronary syndrome, chemistry.chemical_compound, Lp-PLA2, Lipoprotein-associated phospholipase A2, RA1190-1270, medicine, Colchicine, Pharmacokinetics, Intensive care medicine, Repurposing, media_common, ComputingMethodologies_COMPUTERGRAPHICS, Inflammation, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, business.industry, eGFR, estimated glomerular filtration rate, Toxicology and Redox Biology under the frame of their historical evolution, COVID-19, coronavirus disease - 19, DOACs, direct oral anticoagulants, Clinical Practice, chemistry, ROCK, Rho-associated protein kinase, Toxicology. Poisons, ACS, acute coronary syndrome, Safety, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72213392b99a6a946308446638fc594dTest
http://www.sciencedirect.com/science/article/pii/S2214750021001360Test

المؤلفون: Seyed Shahabeddin Mortazavi-Jahromi, Abbas Mirshafiey, Mona Aslani

المصدر: International Immunopharmacology

مصطلحات موضوعية: RhoB, Ras homolog gene family member B, M-CSF, Macrophage CSF, PPP2CA, Protein phosphatase 2 catalytic subunit alpha, RNA pol, RNA polymerase, medicine.medical_treatment, IRF, IFN regulatory factor, v-miRNA, Viral miRNA, DCs, Dendritic cells, MyD88, Myeloid differentiation factor 88, ISGs, IFN-stimulated genes, TLRs, Toll-like receptors, AT1R, Ang II receptor type 1, KCNQ1OT1, KCNQ1 overlapping transcript 1, CYLD, Cylindromatosis, IFNs-I, Type I IFNs, TNF-α, Tumor necrosis factor alpha, cPLA2, Cytoplasmic phospholipase A2, LPS, Lipopolysaccharide, Th cells, T helper cells, LPLs, Lysophospholipids, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, siRNAs, Small interfering RNAs, CNS, Central nervous system, pri-miRNAs, Primary miRNAs, MDA5, Melanoma differentiation-associated protein 5, ERK, Extracellular signal-regulated kinase, MERS-CoV, Middle East respiratory syndrome coronavirus, BBB, Blood-brain barrier, OxPLs, Oxidized phospholipids, MODS, Multiple organ dysfunction syndrome, mPGES-1, Microsomal prostaglandin E synthase-1, RNAi, RNA interference, ADAM17, A disintegrin and metalloproteinase 17, AGO, Argonaute, CRISPR, Cas13 family of clustered regularly interspaced short palindromic repeats, DAMPs, Damage-associated molecular patterns, circRNAs, Circular RNAs, CD, Cluster of differentiation, JAK, Janus kinase, TNFR, TNF receptor, Cytokine Release Syndrome, TRIM27, Tripartite motif-containing protein 27, gp130, Glycoprotein 130, MMP, Matrix metalloproteinase, 2019-nCoV, 2019 novel coronavirus, CCL, C-C motif chemokine ligand, SOCS3, Suppressor of cytokine signaling 3, Immunology, COX, Cyclooxygenase, Sry, Sex-determining region Y, Article, S protein, Spike protein, microRNA, Humans, K, Lysine, CSF, Colony-stimulating factor, RGMB-AS1, RGMB antisense RNA 1, TIMP-I, Tissue inhibitors of matrix metalloproteinases-I, S100A9, S100 calcium-binding protein A9, Pharmacology, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, NOXs, Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, CHD, Coronary heart disease, STAT, Signal transducer and activator of transcription, Virus Internalization, medicine.disease, Viral replication, NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells, miRNAs-based therapy, TBK1, TANK-binding kinase 1, ORF, Open reading frame, SOFA, Sequential organ failure assessment score, lncRNAs, Long non-coding RNAs, CatB/L, Cathepsin B/L, sIL-6R, Soluble IL-6R, ROS, Reactive oxygen species, EAE, Experimental autoimmune encephalomyelitis, RBCs, Red blood cells, MAPK, Mitogen-activated protein kinase, PBMCs, Peripheral blood mononuclear cells, N protein, Nucleocapsid protein, Ig, Immunoglobulin, Cytokine storm, Bioinformatics, Virus Replication, 3'-UTR, 3'-untranslated region, H3, Histone 3, AGEs, Advanced glycation end products, Renin-Angiotensin System, XPO5, Exportin-5, G-CSF, Granulocyte CSF, CXCL, C-X-C motif chemokine ligand, DIC, Disseminated intravascular coagulation, Immunology and Allergy, IL, Interleukin, PG, Prostaglandin, RAS, Renin-Angiotensin system, Amp, Amplifier, MCs, Mast cells, COVID-19, Coronavirus disease 2019, HSP, Heat shock protein, AA, Arachidonic acid, ASOs, Antisense oligonucleotides, IFN, Interferon, mRNA, Messenger RNA, ICU, Intensive care unit, Cytokine, RAGE, Receptor for advanced glycation end products, mIL-6R, Membrane IL-6 receptor, FOXO3, Forkhead box O3, miRNAs, LTs, Leukotrienes, miRISC, MicroRNA-induced silencing complex, IκB-ζ, Inhibitor of nuclear factor kappa B zeta, Signal transduction, me3, Trimethylation, M protein, Membrane protein, APJ, Apelin receptor, AP-1, Activator protein 1, TMPRSS2, Transmembrane serine protease 2, PRR, Pattern recognition receptor, GM-CSF, Granulocyte-macrophage CSF, RIG-I, Retinoic acid-inducible gene I, E protein, Envelope protein, Biology, hsa, Homo sapiens, TXs, Thromboxanes, LOXs, Lipoxygenases, Virus, ER, Endoplasmic reticulum, ARDS, Acute respiratory distress syndrome, Gene regulators, medicine, me2, Dimethylation, Animals, PKCα, Protein kinase C alpha, pre-miRNAs, Precursor miRNAs, DMVs, Double membrane vesicles, ceRNAs, Competing endogenous RNAs, nsp, Non-structural protein, Competing endogenous RNA, SARS-CoV-2, ALI, Acute lung injury, PaO2/FiO2, Pressure of arterial oxygen to fractional inspired oxygen concentration, COVID-19, ACE, Angiotensin-converting enzyme, ANRIL, Antisense noncoding RNA in the INK4 locus, miRNAs, MicroRNAs, MEG3, Maternally expressed gene 3, Review article, MicroRNAs, DMD, Dense matted deposits, TAB, Transforming growth factor β-activated kinase-1 (TAK1)-binding protein, HMGB1, High mobility group box protein 1, Ang, Angiotensin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4706f42d886bb679ed2a6b85453a9cTest
https://pubmed.ncbi.nlm.nih.gov/34601331Test

المؤلفون: Emily Igel, Patrick R. Wolfkiel, Anja Jaeschke, David Y. Hui, April Haller, Melissa A. Orr-Asman

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Apolipoprotein E, Male, Myeloid, Apolipoprotein E2, Apolipoprotein E4, Apolipoprotein E3, Biochemistry, Mice, oxidative stress, Myeloid Cells, HSC, hematopoietic stem cells, ApoE, apolipoprotein E, Chemistry, Inflammasome, bone marrow transplant, TNFα, tumor necrosis factor α, medicine.anatomical_structure, Tumor necrosis factor alpha, lipids (amino acids, peptides, and proteins), Female, Myelopoiesis, medicine.symptom, medicine.drug, Signal Transduction, Research Article, LDL, low-density lipoproteins, Lipoproteins, Inflammation, Mice, Transgenic, Proinflammatory cytokine, Gene product, NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3, Apolipoproteins E, inflammasome, medicine, Animals, Humans, oxLDL, oxidized LDL, Molecular Biology, ApoE polymorphism, HDL, high-density lipoproteins, Cell Biology, Atherosclerosis, IL, interleukin, Mice, Inbred C57BL, Cancer research, LPS, lipopolysaccharides, BSA, bovine serum albumin, cholesterol efflux

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de00fa93eb2ea4fb3ca0f8d15d838ffTest
https://pubmed.ncbi.nlm.nih.gov/34425108Test

المؤلفون: Jihye Lee, Hee-Seop Lee, Seong-Ho Lee, Dmitriy Smolensky

المصدر: International Immunopharmacology

مصطلحات موضوعية: ERK, Extracellular signal-Regulated Kinase, HPU, Helicobactor Pylori Urease, IR, Ischemia/reperfusion, iNOS, Inducible Nitric Oxide Synthase, PERK, Protein kinase R-like Endoplasmic Reticulum Kinase, Alcohol, C/EBPα, CCAT/enhancer Binding Protein α, RIP3, Receptor Interacting Serine/Threonine- Protein kinase3, CXCL11, C-X-C Motif Chemokine 11, IBD, Inflammatory Bowel Disease, DCNB, 2,4-Dinitro-chlorobenzene, IRE1, Inositol-requiring Enzyme 1, 0302 clinical medicine, ACE2, Angiotensin Converting Enzyme 2, Medicine, 4E-BP1, Eukaryotic Translation Initiation Factor 4E Binding Protein 1, SOD, Superoxide Dismutase, 5-HT, 5-Hydroxytryptamine, LPS, Lipopolysaccharide, TLR2, Toll-like Receptor 2, media_common, ER, Estrogen Receptor, IFNγ, Interferon γ, Nrf2, Nuclear Factor Erythroid 2-Related Factor 2, NF-κB, Nuclear Factor κ-light-chain-enhancer of activated B cells, VDCC, Voltage-Dependent Ca2+ Channel, Pogostemon, SYN1, Synapsin-1, PXR, Pregnane X Receptor, 030220 oncology & carcinogenesis, IP3R, Inositol Triphosphate Receptor, Sesquiterpenes, PSD-95, Postsynaptic Density Protein 95, TPH1, Tryptophan Hydroxylase 1, Drug, media_common.quotation_subject, Immunology, CUMS, Chronic Unpredictable Mild Stress, ZO-1, Zonula Occludens-1, Article, WHO, World Health Organization, 03 medical and health sciences, food, ICAM-1, Intracellular Adhesion Molecule-1, Humans, VLDL, Very Low Density Lipoprotein, Pharmacology, IDO-1, Indoleamine 2,3-dioxygenease-1, TNFα, Tumor Necrosis Factor α, MAPK, Mitogen-Activated Protein Kinase, NO, Nitric Oxide, CAT, Catalase, 030104 developmental biology, Patchouli alcohol, mTOR, Mammalian Target of Rapamycin, chemistry, PI3K, Phosphoinositol-3 Kinase, RdRp, RNA-Dependent RNA Polymerase, 0301 basic medicine, CXCL10, C-X-C Motif Chemokine 10, PLpro, Papain-like Protease, Anti-Inflammatory Agents, 3CLpro, 3C-Like Protease, PGE2, Prostaglandin E2, Health benefits, COX2, Cyclooxygenase 2, MLKL, Mixed Lineage Kinase Domain-Like Pseudokinase, chemistry.chemical_compound, 5-FU, 5-Fluorouracil, Immunology and Allergy, CXCL9, C-X-C Motif Chemokine 9, eNOS, Endothelial Nitric Oxide Synthase, biology, Traditional medicine, respiratory system, 5-HTP, 5-Hydroxytryptophan, VCAM-1, Vascular Cell Adhesion Molecule 1, NLRP3, NOD-, LRR- and Pyrin Domain-containing Protein 3, Immunosuppressive Agents, food.ingredient, ATF6, Activating Transcription Factor 6, DSS, Dextran Sulfate Sodium, TXNIP, Thioredoxin Interacting Protein, ROCCs, Receptor-operated Ca2+ Channels, Functional food, PA, Patchouli Alcohol, SCFA, Short Chain Fatty Acid, MDA, Malondialdehyde, Biological mechanisms, RyRs, Ryanodine Receptors, Lung protection, business.industry, PHE, Phenylephrine, GSH-px, Glutathione Peroxidase, MMP9, Matrix Metalloproteinase 9, biology.organism_classification, Antineoplastic Agents, Phytogenic, DTH, Delayed Type Hypersensitivity, PPARγ, Peroxisome Proliferator Activated Receptor γ, HO-1, Heme Oxidase-1, Molecular targets, EGFR, Epidermal Growth Factor Receptor, Kyn, L-Kynurenine, MCP-1, Monocyte Chemoattractant Protein-1, Patchouli, business, human activities, ROS, Reactive Oxygen Species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0bef40b542aa0945c4a6b4a7afa05Test
https://doi.org/10.1016/j.intimp.2020.107056Test