المؤلفون: Ярошенко, А. А., Степанова, В. А., Комарова, Л. С., Сабирьянова, К. А., Бачура, В. Д., Десятова, М. А., Шуман, Е. А., Yaroshenko, A. A., Stepanova, V. А., Komarova, L. S., Sabiryanova, K. А., Bachura, V. D., Desyatova, M. A., Shuman, E. A.

المصدر: Сборник статей

مصطلحات موضوعية: HUMAN GENOME EDITING, CRISPR/CAS9, NHEJ (NON-HOMOLOGOUS END JOINING), VIRAL INFECTIONS, РЕДАКТИРОВАНИЕ ГЕНОМА ЧЕЛОВЕКА, НЕГОМОЛОГИЧНОЕ СОЕДИНЕНИЕ КОНЦОВ, ВИРУСНЫЕ ИНФЕКЦИИ

وصف الملف: application/pdf

العلاقة: Актуальные вопросы современной медицинской науки и здравоохранения: Материалы VI Международной научно-практической конференции молодых учёных и студентов, посвященной году науки и технологий, (Екатеринбург, 8-9 апреля 2021): в 3-х т.; Клинические перспективы применения системы редактирования генома человека (CRISPR/CAS-9) / А. А. Ярошенко, В. А. Степанова, Л. С. Комарова [и др.] // Актуальные вопросы современной медицинской науки и здравоохранения: материалы VI Международной научно-практической конференции молодых учёных и студентов, посвященной году науки и технологий, (Екатеринбург, 8-9 апреля 2021 г.) : в 3-х т. – Екатеринбург : УГМУ, 2021. – Т.1. – с. 1528-1532.; http://elib.usma.ru/handle/usma/6893Test

الإتاحة: http://elib.usma.ru/handle/usma/6893Test

المؤلفون: Hirofumi Nishizono, Ryohei Yasuda, Tal Laviv

المصدر: Frontiers in Genome Editing, Vol 2 (2020)

مصطلحات موضوعية: HITI (homology-independent targeted integration), SLENDR (single-cell labeling of endogenous proteins with homology-directed repair), iGONAD (improved-genome editing via oviductal nucleic acids delivery), HDR (homology-directed repair), NHEJ (non-homologous end joining), Biotechnology, TP248.13-248.65, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/fullTest; https://doaj.org/toc/2673-3439Test

الوصول الحر: https://doaj.org/article/df1d0e499df242beaf2bf4a8aef2d69fTest

المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953da916a138cd7d6b71c2e8c8f9668aTest
http://www.sciencedirect.com/science/article/pii/S2211383521000113Test

المؤلفون: Siyuan Chen, Xiawei Wei, Manni Wang, Yuquan Wei

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3935-3949 (2021)

مصطلحات موضوعية: Senescence, Paclitaxel, DNA repair, NHEJ, non homologous end joining, medicine.medical_treatment, LCLC, large-cell carcinoma, RM1-950, Chemosensitization, DDR, DNA damage response, chemistry.chemical_compound, Non-small cell lung cancer, DNA-PK, DNA-dependent protein kinase, NSCLC, non-small cell lung cancer, medicine, Cytotoxic T cell, General Pharmacology, Toxicology and Pharmaceutics, Lung cancer, Adverse effect, DSB, DNA double-strand breaks, Etoposide, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, Chemotherapy, business.industry, LADC, lung adenocarcinoma, medicine.disease, LSCC, lung squamous cell carcinoma, respiratory tract diseases, M3814, dsDNA, double strand DNA, chemistry, DNA-dependent protein kinase, Cancer research, Original Article, Cell senescence, Therapeutics. Pharmacology, HR, homologous recombination, business, IHC, immunohistochemistry, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48576014833ff0883918307b9873dc5eTest
http://europepmc.org/articles/PMC8727896Test

المؤلفون: Shaheen Akhtar, Joanna Bottomley, Edward Ryder, Daniel M Barrett, Michaela Bruntraeger, Sanger Mouse Genetics, James Bussell, Jonathan Burvill, Radka Platte, Debarati Sethi, Diane Gleeson

المصدر: Methods (San Diego, Calif.)

مصطلحات موضوعية: FASTQ format, Genotyping, Genotype, Genotyping Techniques, Mouse, Computational biology, Biology, Polymerase Chain Reaction, Genome, Article, General Biochemistry, Genetics and Molecular Biology, DNA sequencing, Mice, 03 medical and health sciences, PCR, polymerase chain reaction, Animals, CRISPR, CRISPR, clustered regularly interspaced short palindromic repeat, hom, homozygous, Allele, Molecular Biology, Alleles, QC, 030304 developmental biology, 0303 health sciences, fungi, 030302 biochemistry & molecular biology, sgRNA, single guide RNA, Mutant, food and beverages, High-Throughput Nucleotide Sequencing, NGS, next generation sequencing, het, heterozygous, Amplicon, WT, wild-type, Mice, Mutant Strains, QC, quality control, NHEJ, non-homologous end joining, NGS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79b367f901763da5e833510b51bcdcTest
https://doi.org/10.1016/j.ymeth.2020.10.011Test

المؤلفون: Liwu Fu, Hong Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1400-1411 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: FANCD2, Fanconi anemia protein, DFS, disease-free survival, HNC, head and neck cancer, Cancer therapy, Review, medicine.disease_cause, SCC, squamous cell carcinoma, Metastasis, εPKC, epsilon protein kinase C, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, Polymorphism (computer science), PdG, N2-propano-2′-deoxyguanosine, EC, esophageal cancer, General Pharmacology, Toxicology and Pharmaceutics, FA, Fanconi anemia, Cancer, TGF-β, transforming growth factor β, 0303 health sciences, Progression, GCA, gastric cancer, NRF2, nuclear factor erythroid 2 (NF-E2)-related factor 2, ccRCC, clear-cell renal cell carcinomas, NHEJ, non-homologous end-joining, PC, pancreatic cancer, 030220 oncology & carcinogenesis, CRC, colorectal cancer, NeG, 1,N2-etheno-dGuo, PBMC, peripheral blood mononuclear cell, ALD, alcoholic liver disease, CSCs, cancer stem cells, OvCa, ovarian cancer, COUP-TF, chicken ovalbumin upstream promoter-transcription factor, BCa, bladder cancer, NF-κB, nuclear factor-κB, Single-nucleotide polymorphism, Acetaldehyde, RM1-950, 4-HNE, 4-hydroxy-2-nonenal, OS, overall survival, 03 medical and health sciences, NSCLC, non-small-cell lung, medicine, SNP, MN, micronuclei, Polymorphism, ALDH2, 030304 developmental biology, LCSCs, liver cancer stem cells, MDA, malondialdehyde, business.industry, ALDH2, aldehyde dehydrogenase 2, MDR, multi-drug resistance, OPC, oropharyngeal cancer, HDACs, histone deacetylases, medicine.disease, AMPK, AMP-activated protein kinase, VHL, von Hippel-Lindau, Tumor progression, REV1, Y-family DNA polymerase, NER, nucleotide excision repair pathway, NRRE, nuclear receptor response element, Tumorigenesis, Cancer research, NCEs, normochromic erythrocytes, Therapeutics. Pharmacology, HR, homologous recombination, HCC, hepatocellular carcinoma, business, Carcinogenesis, HNF-4, hepatocyte nuclear factor 4

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900Test
https://doi.org/10.1016/j.apsb.2021.02.008Test

المؤلفون: Shikang Liang, Tom L. Blundell, Amanda K. Chaplin, Aleš Hnízda, Antonia Kefala Stavridi, Robert Appleby

المساهمون: Liang, Shikang [0000-0002-6930-7882], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

المصدر: Progress in Biophysics and Molecular Biology

مصطلحات موضوعية: Materials science, DNA End-Joining Repair, Spatial organisation, DNA Repair, Cryo-electron microscopy, DNA repair, Double-strand breaks, 030303 biophysics, Biophysics, KBM, Ku-binding motif, Computational biology, Article, 03 medical and health sciences, chemistry.chemical_compound, DNA-PK, DNA-dependent protein kinase, PAXX, Paralog of XRCC4 and XLF, XLF, XRCC4-Like Factor, Stages, Strings, Humans, DSB, double-strand break, DNA Breaks, Double-Stranded, Orchestration (computing), vWA, von Willebrand factor type A, cryo-EM, cryo-electron microscopy, PTIP, Pax transcription-activation-domain interacting protein, Molecular Biology, NHEJ, Cryo-EM, IR, ionising radiation, Scaffolds, 0303 health sciences, 53BP1, p53-binding protein 1, Cryoelectron Microscopy, X-ray diffraction, Non-homologous end joining, enzymes and coenzymes (carbohydrates), chemistry, DNA-PKcs, DNA-PK catalytic subunit, NHEJ, non-homologous end joining, X-ray crystallography, PNKP, polynucleotide kinase, APLF, aprataxin and PNKP-like factor, BRCT, BRCA1 C-Terminus domain, lncRNA, long noncoding RNA, HR, homologous recombination, DNA, CTR, C-terminal region

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca43e6e448ffae277c09ed2c9f19bd34Test
https://www.repository.cam.ac.uk/handle/1810/316479Test

المؤلفون: Sheila Maestro, Gloria González-Aseguinolaza, Rafael Aldabe, Nicholas D. Weber, Nerea Zabaleta

المصدر: JHEP Reports

مصطلحات موضوعية: MPS type VII, MPSVII, S/MAR, scaffold matrix attachment regions, PB, piggyBac, gene addition, GalNAc, N-acetyl-D-galactosamine, UCD, urea cycle disorders, Genetic enhancement, medicine.medical_treatment, efficacy, MMA, methylmalonic acidemia, Review, Liver transplantation, medicine.disease_cause, MPS, mucopolysaccharidosis, immune response, IDS, iduronate 2-sulfatase, lncRNA, long non-coding RNA, gene silencing, GSD1a, glycogen storage disorder 1a, AAV, adeno-associated virus, ASOs, antisense oligonucleotides, Genome editing, AHP, acute hepatic porphyrias, HT, hereditary tyrosinemia, IMLD, inherited metabolic liver diseases, PFIC3, progressive familial cholestasis type 3, Immunology and Allergy, NHPs, non-human primates, CRISPR/Cas9, CRISPR associated protein 9, GO, glycolate oxidase, HemA/B, haemophilia A/B, Adeno-associated virus, HDR, homology-directed repair, Transcription activator-like effector nuclease, LNP, Lipid nanoparticles, siRNA, small-interfering RNA, MPR, metabolic pathway reprograming, LDH, lactate dehydrogenase, PH1, Primary hyperoxaluria type 1, gene editing, SRT, substrate reduction therapy, Gastroenterology, Ad, adenovirus, AAT, α1-antitrypsin, PA, propionic acidemia, dCas9, dead Cas9, ERT, enzyme replacement therapy, HDAd, helper-dependent adenovirus, CRISPR, clustered regularly interspaced short palindromic repeats, SB, Sleeping Beauty, LDLR, low-density lipoprotein receptor, MPS type I, MPSI, hepatocytes, OTC, ornithine transcarbamylase, APCs, antigen-presenting cells, DSBs, double-strand breaks, viral vectors, LV, lentivirus, AIP, acute intermittent porphyria, NASH, non-alcoholic steatohepatitis, GT, gene therapy, PKU, phenylketonuria, Computational biology, Gene delivery, Biology, FH, familial hypercholesterolemia, Viral vector, ITR, inverted terminal repetition, ZFN, zinc finger nucleases, GUSB, β-glucuronidase, Internal Medicine, medicine, OLT, orthotopic liver transplantation, Gene silencing, miRNAs, microRNAs, ASGPR, asialoglycoprotein receptor, ALAS1, aminolevulic synthase 1, TALEN, transcription activator-like effector nucleases, CBS, cystathionine β-synthase, PEG, polyethylene glycol, PEI, polyethyleneimine, TTR, transthyretin, Hepatology, IDUA, α-L-iduronidase, toxicity, ASGCT, American Society of Gene and Cell Therapy, CN, Crigel-Najjar, STK25, serine/threonine protein kinase 25, VLDLR, very-low-density lipoprotein receptor, WD, Wilson’s disease, FSP27, fat-specific protein 27, NHEJ, non-homologous end joining, Non-viral vectors, LTR, long terminal repeat, apoB/E, apolipoprotein B/E, RV, retrovirus, PCSK9, proprotein convertase subtilisin/kexin type 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cc33bd8f559ae9ccb64e180a7a274aTest
http://europepmc.org/articles/PMC8203845Test

المؤلفون: Danielle G. Passos-Silva, Elizângela Almeida Rocha, Dawidson Assis Gomes, Joao P. Vieira-da-Rocha, Richard McCulloch, Carlos Renato Machado, Isabela Cecília Mendes

المصدر: DNA Repair

مصطلحات موضوعية: Alkylation, DNA Repair, RAD51, DNA damage response, Biochemistry, DNA Adducts, chemistry.chemical_compound, 0302 clinical medicine, ICL, interstrand crosslink, kDNA, kinetoplast DNA, BER, base excision repair, 0303 health sciences, biology, PCF, procyclic form, Cell cycle, Cell biology, MMS, methyl methanesulfonate, 030220 oncology & carcinogenesis, Kinetoplast, BSF, bloodstream form, Mitochondrial DNA, DNA damage, DNA repair, Life cycle, Trypanosoma brucei brucei, Replication, MMR, mismatch repair, Trypanosoma brucei, Trypanosome, Article, PI, propidium iodide, 03 medical and health sciences, NER, nucleotide excision repair, parasitic diseases, TLS, translesion synthesis, Molecular Biology, DR, direct repair, 030304 developmental biology, Cell Cycle Checkpoints, Cell Biology, DNA, Protozoan, biology.organism_classification, Oxidative Stress, chemistry, NHEJ, non-homologous end joining, DSBs, double strand breaks, Rad51 Recombinase, HR, homologous recombination, nDNA, nuclear DNA, VSG, variant surface glycoprotein, Repair, DNA, DNA Damage

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865a1261c26a5c5116370ba7eff05f6eTest
https://doi.org/10.1016/j.dnarep.2018.11.005Test

المؤلفون: Hongquan Guo, Xinfeng Liu, Juanji Li, Xiaolei Shi, Yi Xie, Pengfei Xu, Yunzi Li, Qian Liu, Rui Sun, Ye Hong, Mengna Peng, Gelin Xu

المصدر: Redox Biology
Redox Biology, Vol 18, Iss, Pp 158-172 (2018)

مصطلحات موضوعية: 0301 basic medicine, BRCT, BRCA1 C-terminal, GPX3, glutathione peroxidase 3, 4-HNE, 4-hydroxynonenol, OGD, oxygen-glucose deprivation, GCLM, glutamate-cysteine ligase regulator subunit, Iba-1, ionized calcium-binding adapter molecule-1, Clinical Biochemistry, SOD1, superoxide dismutase 1, HO-1, heme oxygenase 1, medicine.disease_cause, Biochemistry, NPCs, neural precursor cells, CaMKII, calcium/calmodulin-dependent protein kinase II, Lipid peroxidation, chemistry.chemical_compound, CA1, cornu ammonis 1, NSCs, neural stem cells, 3-NT, 3-nitrotyrosine, XRE, xenobiotic responsive element, skin and connective tissue diseases, lcsh:QH301-705.5, BER, base excision repair, GFP, green fluorescent protein, PSD95, postsynaptic density protein 95, chemistry.chemical_classification, lcsh:R5-920, DCX, doublecortin, ALS, amyotrophic lateral sclerosis, NRF2, nuclear factor (erythroid-derived 2)-like 2, GPX4, glutathione peroxidase 4, 8-OHDG, 8-hydroxy-2′-deoxyguanosine, Signal transduction, lcsh:Medicine (General), Ischemia/Reperfusion, Research Paper, NQO1, NAD(P)H dehydrogenase (quinone 1), DNA damage, DNA repair, Ischemia, I/R, ischemia/reperfusion, CNS, central nervous system, GCLC, glutamate-cysteine ligase catalytic, NRF2, 03 medical and health sciences, ROS, reactive oxygen species, NER, nucleotide excision repair, medicine, MCAO, middle cerebral artery occlusion, SOD2, superoxide dismutase 2, Reactive oxygen species, AD, Alzheimer disease, Organic Chemistry, GFAP, glial fibrillary acidic protein, BRCA1, medicine.disease, ARE, antioxidative response element, 030104 developmental biology, lcsh:Biology (General), chemistry, NHEJ, non-homologous end joining, Oxidative stress, BRCA1, breast cancer susceptibility protein 1, DSBs, double strand breaks, Cancer research, HR, homologous recombination, Reperfusion injury

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e034e7c5102b1e7cd98f372f511aacTest
https://doi.org/10.1016/j.redox.2018.06.012Test