المؤلفون: Xia, Chun-Hong, Ferguson, Ian, Li, Mei, Kim, Audrey, Onishi, Alex, Li, Lucy, Su, Bonnie, Gong, Xiaohua

مصطلحات موضوعية: Eye Disease and Disorders of Vision, Genetics, Neurosciences, Gene Therapy, Underpinning research, 1.1 Normal biological development and functioning, Eye, Animals, CRISPR-Associated Protein 9, Cells, Cultured, Dependovirus, Fluorescent Antibody Technique, Indirect, Gene Knockout Techniques, Gene Transfer Techniques, Genetic Therapy, Genetic Vectors, Green Fluorescent Proteins, Hydrogen-Ion Concentration, Mice, Mice, Inbred C57BL, Photoreceptor Cells, Vertebrate, RNA, Real-Time Polymerase Chain Reaction, Retinal Pigment Epithelium, Sodium-Hydrogen Exchangers, Transduction, Genetic, NHE8, Retinal pigment epithelium, Photoreceptor cells, CRISPR/Cas9, pH regulation, Medical Biochemistry and Metabolomics, Opthalmology and Optometry, Ophthalmology & Optometry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5v66z559Test

المؤلفون: Claudio Bernardazzi, Irshad Ali Sheikh, Hua Xu, Fayez K. Ghishan

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10857

مصطلحات موضوعية: NHE8, eyes, kidney, testis, gastrointestinal tract, lungs

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Biology; https://dx.doi.org/10.3390/ijms231810857Test

الإتاحة: https://doi.org/10.3390/ijms231810857Test

المؤلفون: Kondelin, Johanna, Gylfe, Alexandra E., Lundgren, Sofie, Tanskanen, Tomas, Hamberg, Jiri, Aavikko, Mervi, Palin, Kimmo, Ristolainen, Heikki, Katainen, Riku, Kaasinen, Eevi, Taipale, Minna, Taipale, Jussi, Renkonen-Sinisalo, Laura, Jarvinen, Heikki, Bohm, Jan, Mecklin, Jukka-Pekka, Vahteristo, Pia, Tuupanen, Sari, Aaltonen, Lauri A., Pitkanen, Esa

المساهمون: Research Programs Unit, Genome-Scale Biology (GSB) Research Program, Department of Medical and Clinical Genetics, Medicum, Lauri Antti Aaltonen / Principal Investigator, Jussi Taipale / Principal Investigator, Clinicum, Department of Surgery, II kirurgian klinikka, Heikki Järvinen / Principal Investigator, HUS Abdominal Center

مصطلحات موضوعية: REPAIR-DEFICIENT CANCERS, DNA MISMATCH REPAIR, FRAMESHIFT MUTATIONS, TARGET GENES, REPEAT SEQUENCES, INTESTINAL NHE8, BETA-ALANINE, COLON-CANCER, INSTABILITY, EXPRESSION, 3122 Cancers

وصف الملف: application/pdf

العلاقة: L.A. Aaltonen received funding from the Academy of Finland (Finnish Center of Excellence Program 2012-2017; 1250345); The Finnish Cancer Society, Sigrid Juselius Foundation, Jane and Aatos and Erkko Foundation, and SYSCOL (an EUFP7 Collaborative Project), 258236. J.K. Kondelin received funding from Biomedicum Helsinki Foundation, Otto Malm Foundation, Ida Montin Foundation, Orion-Farmos Research Foundation, Oskar Oflunds Stiftelse, Maud Kuistila Memorial Foundation, and The Doctoral Programme in Biomedicine in the Doctoral School of Health Sciences at University of Helsinki. K.J. Palin received funding from the Nordic Information for Action eScience Center (NIASC), the Nordic Center of Excellence financed by NordForsk (project 62721).; Kondelin , J , Gylfe , A E , Lundgren , S , Tanskanen , T , Hamberg , J , Aavikko , M , Palin , K , Ristolainen , H , Katainen , R , Kaasinen , E , Taipale , M , Taipale , J , Renkonen-Sinisalo , L , Jarvinen , H , Bohm , J , Mecklin , J-P , Vahteristo , P , Tuupanen , S , Aaltonen , L A & Pitkanen , E 2017 , ' Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer ' , Cancer Research , vol. 77 , no. 15 , pp. 4078-4088 . https://doi.org/10.1158/0008-5472.CAN-17-0682Test; ORCID: /0000-0002-1333-8049/work/91815953; ORCID: /0000-0001-6839-4286/work/101502547; 85026746479; 9572c67f-8c8e-4d6f-85ed-98a1bf32130b; http://hdl.handle.net/10138/297913Test; 000406677800010

الإتاحة: http://hdl.handle.net/10138/297913Test

المؤلفون: Lei, Xuelian, Cai, Lin, Li, Xiao, Xu, Hua, Geng, Chong, Wang, Chunhui

المساهمون: Univ Arizona, Hlth Sci Ctr

المصدر: The Korean Journal of Physiology & Pharmacology ; 22 ; 3 ; 269

مصطلحات موضوعية: Anti-inflammatory agents, Colitis, Diarrhea, NHE8 protein, Somatostatin

العلاقة: https://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2018.22.3.269Test; Lei X, Cai L, Li X, Xu H, Geng C, Wang C. Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model. Korean J Physiol Pharmacol. 2018 May;22(3):269-275. https://doi.org/10.4196/kjpp.2018.22.3.269Test; http://hdl.handle.net/10150/627780Test; KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

الإتاحة: https://doi.org/10.4196/kjpp.2018.22.3.269Test
http://hdl.handle.net/10150/627780Test

المؤلفون: C. Chris Yun, Katerina Nikolovska, Ursula Seidler, Anna Seidler, Zhenglin Yuan, Sunil Yeruva, Yan Yu, Mahdi Amiri, Kunyan Zhou

المصدر: Cellular Physiology and Biochemistry, Vol 52, Iss 5, Pp 1017-1038 (2019)
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Sodium-Hydrogen Exchangers, Physiology, Enterocyte, Intracellular pH, pHi-regulation, Article, lcsh:Physiology, lcsh:Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Gene expression, medicine, Humans, Protein Isoforms, lcsh:QD415-436, RNA, Messenger, Epithelial polarity, NHE8, Gene knockdown, Sodium-Hydrogen Exchanger 1, lcsh:QP1-981, Chemistry, Cell Membrane, NHE2, Intestinal electrolyte transport, NHE3, Hydrogen-Ion Concentration, Apical membrane, Molecular biology, NBCn1, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Cell culture, 030220 oncology & carcinogenesis, Caco-2 Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69aa3a8f25e53cb99ba65159cd76a66Test
https://www.cellphysiolbiochem.com/Articles/000070Test/

المؤلفون: Hua Xu, Fayez K. Ghishan, Jing Li, Hao Chen

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 19-31 (2019)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: WT, wild type, 0301 basic medicine, DMEM, Dulbecco's modified Eagle medium, Carcinogenesis, Colorectal cancer, EdU, 5-ethynyl-2’-deoxyuridine, Cell Count, medicine.disease_cause, Receptors, G-Protein-Coupled, Mice, chemistry.chemical_compound, AOM, azoxymethane, NSG, NOD scid gamma, PCR, polymerase chain reaction, 0302 clinical medicine, DSS, dextran sodium sulfate, Wnt Signaling Pathway, beta Catenin, Original Research, NHE8, Mice, Knockout, Stem Cells, Dextran Sulfate, Gastroenterology, LGR5, Wnt signaling pathway, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, Colitis, EGFP, enhanced green fluorescent protein, mRNA, messenger RNA, Organoids, Editorial, NHE, Na+/H+ exchanger, CRC, colorectal cancer, Immunohistochemistry, FACS, fluorescence-activated cell sorter, 030211 gastroenterology & hepatology, Colorectal Neoplasms, Sodium-Hydrogen Exchangers, Azoxymethane, In situ hybridization, Biology, Proto-Oncogene Proteins c-myc, Lgr5, 03 medical and health sciences, Cell Line, Tumor, Intestinal Neoplasms, medicine, Animals, Humans, lcsh:RC799-869, Cell Proliferation, KO, knockout, Hepatology, Cell growth, Membrane Transport Proteins, Biological Transport, medicine.disease, UC, ulcerative colitis, 030104 developmental biology, chemistry, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, Colorectal Tumor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a675ab57213dfa92c2dfdb3960a7581Test
https://doi.org/10.1016/j.jcmgh.2018.08.005Test

المؤلفون: Katerina Nikolovska (9731222)

مصطلحات موضوعية: Animal Physiology - Cell, caco2bbe, NHE8, pH-fluorometry

العلاقة: https://figshare.com/articles/figure/Supplementary_data-C-00582-2020R1/14724330Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14724330Test

المؤلفون: Xiao Li, Hua Xu, Lin Cai, Chong Geng, Xuelian Lei, Chunhui Wang

المصدر: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Agonist, Diarrhea, medicine.medical_specialty, Physiology, medicine.drug_class, Infectious Colitis, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, Downregulation and upregulation, Internal medicine, parasitic diseases, medicine, Colitis, Receptor, Pharmacology, Anti-inflammatory agents, business.industry, medicine.disease, 030104 developmental biology, Somatostatin, Endocrinology, 030211 gastroenterology & hepatology, Original Article, NHE8 protein, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c961966da1983a8efef39bf2be13f29Test
http://europepmc.org/articles/PMC5928340Test

المؤلفون: Chun-hong Xia, Ian D. Ferguson, L. Li, Audrey Kim, Alex Onishi, Mei Li, Xiaohua Gong, Bonnie Su

المصدر: Exp Eye Res

مصطلحات موضوعية: 0301 basic medicine, Retinal degeneration, genetic structures, Mutant, Fluorescent Antibody Technique, Retinal Pigment Epithelium, Medical Biochemistry and Metabolomics, Inbred C57BL, Eye, Ophthalmology & Optometry, Gene Knockout Techniques, Mice, Transduction, Genetic, CRISPR-Associated Protein 9, Fluorescent Antibody Technique, Indirect, Cells, Cultured, NHE8, Gene knockdown, Cultured, biology, Chemistry, Gene Transfer Techniques, Gene Therapy, Dependovirus, Hydrogen-Ion Concentration, Sensory Systems, Cell biology, medicine.anatomical_structure, Rhodopsin, pH regulation, Photoreceptor Cells, Vertebrate, Indirect, Sodium-Hydrogen Exchangers, Intracellular pH, Cells, 1.1 Normal biological development and functioning, Genetic Vectors, Green Fluorescent Proteins, Real-Time Polymerase Chain Reaction, Article, Viral vector, 03 medical and health sciences, Cellular and Molecular Neuroscience, Transduction, Genetic, Underpinning research, Opthalmology and Optometry, medicine, Genetics, Animals, Photoreceptor Cells, CRISPR/Cas9, Eye Disease and Disorders of Vision, Retinal pigment epithelium, Vertebrate, Neurosciences, Genetic Therapy, medicine.disease, eye diseases, Mice, Inbred C57BL, Ophthalmology, 030104 developmental biology, biology.protein, RNA, sense organs, Immunostaining

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5120c868a54b8353b359d6b2b32d47dcTest
https://pubmed.ncbi.nlm.nih.gov/29958869Test

المؤلفون: Riku Katainen, Heikki Järvinen, Jussi Taipale, Johanna Kondelin, Sofie Lundgren, Pia Vahteristo, Jukka-Pekka Mecklin, Laura Renkonen-Sinisalo, Tomas Tanskanen, Sari Tuupanen, Alexandra E. Gylfe, Eevi Kaasinen, Heikki Ristolainen, Kimmo Palin, Mervi Aavikko, Jiri Hamberg, Minna Taipale, Lauri A. Aaltonen, Esa Pitkänen, Jan Böhm

المساهمون: Research Programs Unit, Genome-Scale Biology (GSB) Research Program, Department of Medical and Clinical Genetics, Medicum, Lauri Antti Aaltonen / Principal Investigator, Jussi Taipale / Principal Investigator, Clinicum, Department of Surgery, II kirurgian klinikka, Heikki Järvinen / Principal Investigator, HUS Abdominal Center

المصدر: Cancer research. 77(15)

مصطلحات موضوعية: 0301 basic medicine, EXPRESSION, Cancer Research, Mutation rate, INTESTINAL NHE8, INSTABILITY, 3122 Cancers, DNA Mutational Analysis, FRAMESHIFT MUTATIONS, Biology, Frameshift mutation, 03 medical and health sciences, 0302 clinical medicine, medicine, TARGET GENES, Humans, Mutation frequency, Indel, Genetics, Models, Statistical, COLON-CANCER, Microsatellite instability, REPAIR-DEFICIENT CANCERS, DNA MISMATCH REPAIR, REPEAT SEQUENCES, medicine.disease, 3. Good health, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Mutation, Microsatellite, DNA mismatch repair, Microsatellite Instability, BETA-ALANINE, Colorectal Neoplasms, INDEL Mutation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8431f248a1bed5b2d3f0a53cab2f2fbTest
https://pubmed.ncbi.nlm.nih.gov/28611049Test