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Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms

التفاصيل البيبلوغرافية
العنوان: Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
المؤلفون: Lu, Ping-Hsun, Tseng, Chien-Wei, Lee, Jing-Ling, Lee, En-Yu, Lin, Yu-Ping, Lin, I-Hsin, Yu, Min-Chien, Lu, Kuo-Cheng, Kuo, Ko-Lin
المصدر: Pharmacological Research-Modern Chinese Medicine
بيانات النشر: Elsevier BV, 2022.
سنة النشر: 2022
مصطلحات موضوعية: ALI, acute lung injury, PrsDMe, prosapogenin D methyl ester, ASC, C-terminal caspase recruitment domain, AT1R, angiotensin II type I receptor, RNP, ribonucleoprotein, CCR, CC chemokine receptor, MPO, myeloperoxidase, Review Article, GC-MS, gas chromatography-mass spectrometry, Nrf2, nuclear factor erythroid-related factor 2, PLE, perilla leaf extract, AKT1, AKT serine/threonine kinase 1, CoVs, coronaviruses, TNF-α, tumor necrosis factor-α, GSK3β, glycogen synthase kinase beta, HIV-1, human immunodeficiency virus type 1, VCAM-1, vascular cell adhesion molecule 1, PRRs, pattern recognition receptors, ADRP, ADP ribose phosphatase, BALF, bronchoalveolar lavage fluid, ILC3, type 3 innate lymphoid cells, DIC, disseminated intravascular coagulation, RCT, randomized controlled trial, JAK2, Janus kinase 2, NF-κB, nuclear factor kappa B, ICAM-1, intercellular adhesion molecule 1, antivirus, PLpro, papain-like protease, Jing Si Herbal Drink, NO, nitrogen monoxide, RBD, receptor-binding domain, VEGF, vascular endothelial growth factor, STAT, signal transducer and activator of transcription, MMP-9, matrix metallopeptidase 9, Ang-II, angiotensin-II, LC–MS, liquid chromatography-mass spectrometry, COX-2, cyclooxygenase-2, iNOS, inducible nitric oxide synthase, LPS, lipopolysaccharide, TCM, traditional Chinese medicine, GM-CSF, granulocyte-macrophage colony-stimulating factor, NK, natural killer, PI3K, phosphoinositide 3-kinase, CPE, cytopathogenic effect, TLR, Toll-like receptor, ATF2, activating transcription factor 2, NETs, neutrophil extracellular traps, RA, rosmarinic acid, JSHD, Jing Si herbal drink, NEK7, NIMA-related kinase 7, RdRP, RNA-dependent RNA polymerase, HLH, hemophagocytic lymphohistiocytosis, mechanism, ACE2, angiotensin-converting enzyme 2, complex mixtures, NLRP3, NLR family pyrin domain-containing 3, WHO, World Health Organization, ROS, reactive oxygen species, 3CLpro, 3-chymotrypsin-like cysteine protease, SOD, superoxide dismutase, TGF-β, transforming growth factor-β, RORγ, RAR-related orphan receptor γ, NE, neutrophil elastase, PD, platycodin D, IFN, interferon, CSFR, colony-stimulating factor receptor, TXA2, thromboxane A2, VOC, variants of concern, ARDS, acute respiratory distress syndrome, citH3, citrullinated H3, PG, Platycodon grandiflorum, COVID-19, herbs, DA, dehydromatricarin A, HSP70, heat shock protein 70, SM, Seomae mugwort, anti-inflammation, HIF-1, hypoxia-inducible factor 1, HMGB1, high mobility group box 1, AA, Artemisia argyi, Mpro, main protease, COPD, chronic obstructive pulmonary disease, CSF, colony-stimulating factor, DAMPs, damage-associated molecular patterns, Nsps, nonstructural proteins, TMPRSS2, transmembrane serine protease 2, MAPK, mitogen-activated protein kinase
الوصف: Background : SARS-CoV-2 has led to a sharp increase in the number of hospitalizations and deaths from pneumonia and multiorgan disease worldwide; therefore, SARS-CoV-2 has become a global health problem. Supportive therapies remain the mainstay treatments against COVID-19, such as oxygen inhalation, antiviral drugs, and antibiotics. Traditional Chinese medicine (TCM) has been shown clinically to relieve the symptoms of COVID-19 infection, and TCMs can affect the pathogenesis of SARS-CoV-2 infection in vitro. Jing Si Herbal Drink (JSHD), an eight herb formula jointly developed by Tzu Chi University and Tzu Chi Hospital, has shown potential as an adjuvant treatment for COVID-19 infection. A randomized controlled trial (RCT) of JSHD as an adjuvant treatment in patients with COVID-19 infection is underway Objectives : This article aims to explore the efficacy of the herbs in JSHD against COVID-19 infection from a mechanistic standpoint and provide a reference for the rational utilization of JSHD in the treatment of COVID-19. Method : We compiled evidence of the herbs in JSHD to treat COVID-19 in vivo and in vitro. Results : We described the efficacy and mechanism of action of the active ingredients in JSHD to treat COVID-19 based on experimental evidence. JSHD includes 5 antiviral herbs, 7 antioxidant herbs, and 7 anti-inflammatory herbs. In addition, 2 herbs inhibit the overactive immune system, 1 herb reduces cell apoptosis, and 1 herb possesses antithrombotic ability. Conclusion : Although experimental data have confirmed that the ingredients in JSHD are effective against COVID-19, more rigorously designed studies are required to confirm the efficacy and safety of JSHD as a COVID-19 treatment.
Graphical Abstract Image, graphical abstract
تدمد: 2667-1425
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2244e4d95e5172a8359236fa899ba577Test
https://doi.org/10.1016/j.prmcm.2021.100024Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....2244e4d95e5172a8359236fa899ba577
قاعدة البيانات: OpenAIRE
الوصف
تدمد:26671425