المؤلفون: Yun Dai, Zhuo Yu, Dandan Sun, Hao Yang, Liu Song, Shulan Han, Caitriona M. O'Driscoll, Jianfeng Guo, Di Chu, Jie Ma, Yifang Zou

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 378-393 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PERK, PKR-like ER kinase, Colorectal cancer, medicine.medical_treatment, CXCL9, C-X-C motif chemokine 9, ECL, enhanced chemiluminescence, EE, encapsulation efficiency, chemistry.chemical_compound, CRT, calreticulin, UPR, unfolded protein response, 0302 clinical medicine, Cancer immunotherapy, NP, nanoparticle, CTLA-4, cytotoxic T lymphocyte antigen 4, General Pharmacology, Toxicology and Pharmaceutics, IL-6, interleukin-6, chemistry.chemical_classification, 0303 health sciences, Nano drug delivery system, TME, tumor microenvironment, IL-10, interleukin-10, FA, folate, CXCL10, C-X-C motif chemokine 10, LC, loading capacity, TAAs, tumor-associated antigens, Tumor microenvironment, Ginsenoside, 030220 oncology & carcinogenesis, CRC, colorectal cancer, Immunogenic cell death, Original Article, Immunotherapy, DCs, dendritic cells, HMGB1, high-mobility group box 1, ATP, adenosine triphosphate, PVDF, polyvinylidene fluoride, ATF6, activating transcription factor 6, ICD, immunogenic cell death, p-PERK, phosphorylation of PERK, IRE1, inositol-requiring enzyme 1, QTN, quercetin, MMR, mismatch repair, RM1-950, ER, endoplasmic reticulum, 03 medical and health sciences, ROS, reactive oxygen species, medicine, Chemotherapy, IL-12, interleukin-12, Combination therapy, IFN-γ, interferon-gamma, PEG, polyethylene glycol, 030304 developmental biology, Reactive oxygen species, business.industry, MDSCs, myeloid derived suppressor cells, CI, combination index, NAC, N-acetyl-l-cysteine, medicine.disease, Immune checkpoint, Blockade, PD-L1, programmed death-ligand 1, chemistry, DAMPs, damage-associated molecular patterns, MR, molar ratio, p-IRE1, phosphorylation of IRE1, Cancer research, IL-4, interleukin-4, Therapeutics. Pharmacology, PFA, paraformaldehyde, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6dd4b7090c45d73c9ae54ee9fd9f2Test
http://www.sciencedirect.com/science/article/pii/S2211383521002173Test

المؤلفون: Yi Lu, Zhongjian Chen, Wei Wu, Pijush Kumar Paul, Quangang Zhu, Jianping Qi

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)

مصطلحات موضوعية: CPP, cell penetrating peptide, RGD, Arg-Gly-Asp, FA - Folic acid, DDVAP, desmopressin acetate, GRAS, generally recognized as safe, PLA, poly(latic acid), EPR, electron paramagnetic resonance, pI, isoelectric point, PLGA, poly(lactic-co-glycolic acid), MSNs, mesoporous silica nanoparticles, Review, FcRn, Fc receptor, GIPET, gastrointestinal permeation enhancement technology, SGC, sodium glycocholate, Bioinformatics, FA, folic acid, EDTA, ethylene diamine tetraacetic acid, 0302 clinical medicine, Medicine, MCT-1, monocarborxylate transporter 1, General Pharmacology, Toxicology and Pharmaceutics, health care economics and organizations, PBPK, physiologically based pharmacokinetics, STC, sodium taurocholate, 0303 health sciences, IBD, inflammatory bowel disease, pHPMA, N-(2-hydroxypropyl)methacrylamide, PVA, poly vinyl alcohol, Enzyme inhibitor, HPMCP, hydroxypropyl methylcellulose phthalate, CaP, calcium phosphate, GI, gastrointestinal, PGA, poly-γ-glutamic acid, Oral delivery, HBsAg, hepatitis B surface antigen, TMC, N-trimethyl chitosan, Permeation enhancer, LBNs, lipid-based nanoparticles, 030220 oncology & carcinogenesis, SNEDDS, self-nanoemulsifying drug delivery systems, Parenteral route, SDC, sodium deoxycholate, DCs, dendritic cells, SIF, simulated intestinal fluids, NLCs, nanostructured lipid carriers, Stability, VB12, vitamin B12, WGA, wheat germ agglutinin, education, High selectivity, RM1-950, EPD, empirical phase diagrams, Clinical, 03 medical and health sciences, PPs, proteins and peptides, TfR, transferrin receptors, CAGR, compound annual growth, LMWP, low molecular weight protamine, SAR, structure–activity relationship, Tf, transferrin, IBD - Inflammatory bowel disease, sCT, salmon calcitonin, sc, subcutaneous, GLP-1, glucagon-like peptide 1, Tf transferrin, 030304 developmental biology, PCL, polycarprolacton, PCA, principal component analysis, ILs, ionic liquids, business.industry, Proteins, NAC, N-acetyl-l-cysteine, UEA1, ulex europaeus agglutinin 1, SLNs, solid lipid nanoparticles, PAA, polyacrylic acid, SGF, simulated gastric fluids, DTPA, diethylene triamine pentaacetic acid, GALT, gut-associated lymphoid tissue, CD - Crohn's disease, Clinical trial, FDA, U.S. Food and Drug Administration, UC, ulcerative colitis, SNAC, sodium N-[8-(2-hydroxybenzoyl)amino]caprylate, COPD, chronic obstructive pulmonary disease, RTILs, room temperature ionic liquids, TAT, trans-activating transcriptional peptide, UC - Ulcerative colitis, BSA, bovine serum albumin, CD, Crohn's disease, Therapeutics. Pharmacology, ASBT, apical sodium-dependent bile acid transporter, Peptides, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173Test
https://doi.org/10.1016/j.apsb.2021.04.001Test

المؤلفون: Wei Zhang, Yilan Shen, Zongshu Xian, Tao Ding, Lei Han, Dianwen Ju, Zhiyong Guo, Jiajun Fan, Xiaobin Mei, Wei Chen, Qi Bian, Zhonglian Cao, Xin Jin

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 127-142 (2021)

مصطلحات موضوعية: BUN, blood urea nitrogen, SDS-PAGE, SDS-polyacrylamide gel electrophoresis, AGEs, advanced glycation end products, Diabetic nephropathy, AST, aspartate aminotransferase, Pharmacology, Interleukin-22, medicine.disease_cause, IL-22, interleukin-22, Interleukin 22, 0302 clinical medicine, GSEA, gene set enrichment analysis, ESRD, end-stage renal disease, β2-MG, β2 microglobulin, FATPs, fatty acid transport proteins, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, eGFR, estimated glomerular filtration rate, ECM, extracellular matrix, Vascular endothelial growth factor B, VEGFR, vascular endothelial growth factor receptor, Lipotoxicity, HbA1c%, glycosylated hemoglobin, 030220 oncology & carcinogenesis, Original Article, ACR, urine albumin-to-creatinine ratio, medicine.symptom, Fusion protein, GBM, glomerular basement membrane, Inflammation, Ccr, creatinine clearance rate, KEGG, Kyoto Encyclopedia of Genes and Genomes, DN, diabetic nephropathy, 03 medical and health sciences, ROS, reactive oxygen species, Downregulation and upregulation, ALT, alanine aminotransferase, medicine, TEM, transmission electron microscopy, NRP-1, neuropilin-1, 030304 developmental biology, ADFP, adipocyte differentiation-related protein, business.industry, VEGF-B, vascular endothelial growth factor B, lcsh:RM1-950, FA, fatty acid, NLRP3, NOD-like receptor family pyrin domain-containing protein 3, NAC, N-acetyl-l-cysteine, H&E, hematoxylin & eosin, medicine.disease, PAS, periodic acid-Schiff, lcsh:Therapeutics. Pharmacology, business, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f219822cc51b051f7ece0ce7f7e9b55Test
https://doi.org/10.1016/j.apsb.2020.07.002Test

المؤلفون: Kazuo Inoue, Wataru Nomura, Teruo Kawada, Su-Ping Ng, Haruya Takahashi, Tsuyoshi Goto

المصدر: Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101127-(2021)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: medicine.medical_specialty, Ucp1, QH301-705.5, Short Communication, p38 mitogen-activated protein kinases, ERK, extracellular receptor kinase, Biophysics, QD415-436, SEM, standard error of the mean, Biochemistry, iWAT, inguinal white adipose tissue, chemistry.chemical_compound, Beige adipocytes, Internal medicine, Methylglyoxal, NEFA, non-esterified fatty acids, medicine, Glycolysis, Protein kinase A signaling, Biology (General), Kinase, NAC, N-acetyl-l-cysteine, Metabolism, Thermogenin, Endocrinology, chemistry, MG, methylglyoxal, JNK, c-Jun N-terminal kinase, CREB, cAMP response element-binding protein, PKA, protein kinase A, JNK, BBGC, S-p-bromobenzylglutathione cyclopentyl diester, HSL, hormone-sensitive lipase, Thermogenesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cd636c03bee25a1527d75bef884e86Test
http://www.sciencedirect.com/science/article/pii/S2405580821002211Test

المؤلفون: King Ming Chan, Man Long Kwok

المصدر: Toxicology Reports, Vol 7, Iss, Pp 822-835 (2020)
Toxicology Reports

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Cytotoxicity, LC20, lethal concentration of 20 % population, sod2, superoxide dismutase 2 gene, 010501 environmental sciences, Toxicology, medicine.disease_cause, 01 natural sciences, Casp9, caspase 9 protein, Cd, cadmium, 0302 clinical medicine, LC, lethal concentration, Caspase, Cu, copper, Caspase-9, biology, Chemistry, z, zebrafish, Liver cell, Regular Article, Cell biology, Casp8, caspase 8 protein, VE, tocopherol (Vitamin E), GST, glutathione-S-transferase protein, Combined effects, SOD, superoxide dismutase proteins, ccs, copper chaperone for superoxide dismutase gene, cat, catalase gene, PBS, phosphate-buffered saline, CAT, catalase protein, ybx1, Y box-binding protein 1 gene, Caspase 3, Caspase 8, LC50, median lethal concentration, 03 medical and health sciences, Casp3, caspase 3 protein, lcsh:RA1190-1270, gr, glutathione reductase gene, medicine, ef1a, elongation factor 1-alpha gene, Cell damage, 0105 earth and related environmental sciences, ComputingMethodologies_COMPUTERGRAPHICS, lcsh:Toxicology. Poisons, NAC, N-acetyl-l-cysteine, sod1, superoxide dismutase 1 gene, medicine.disease, GR, glutathione reductase protein, gst, glutathione-S-transferase gene, mtDNA, mitochondrial DNA, Apoptosis, BCS, bathocuproinedisulfonic acid disodium salt, biology.protein, Mitochondrial function, 030217 neurology & neurosurgery, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0402719444dde34edacafe8222a5be9Test
http://www.sciencedirect.com/science/article/pii/S2214750020303474Test

المؤلفون: Boris Görg, Hans-Jürgen Bidmon, Barbara Biermann, Dieter Häussinger, Andreas S. Reichert, Nikolaj Klöcker, Marcel Zimmermann, Kaihui Lu

المصدر: EBioMedicine, Vol 48, Iss, Pp 539-553 (2019)
EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, CCCP, carbonyl cyanide m-chlorophenylhydrazone, Taurine, Cirrhosis, Research paper, Biopsy, CQ, chloroquine, lcsh:Medicine, Pharmacology, WB, Western Blot, Liver disease, chemistry.chemical_compound, Mice, 0302 clinical medicine, LC3, microtubule-associated protein 1A/1B-light chain 3, Hyperammonemia, Hepatic encephalopathy, Cells, Cultured, NAC, N-acetyl-L-cysteine, Liver injury, Neurons, lcsh:R5-920, Chemistry, General Medicine, Hydrogen-Ion Concentration, Lysosome, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Autopsy, Rapa, rapamycin, lcsh:Medicine (General), TGM2, transglutaminase 2, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, mQC, mitochondrial quality control, ROS, reactive oxygen species, medicine, Autophagy, Animals, Humans, Protein Glutamine gamma Glutamyltransferase 2, EM, electron microscopy, IF, Immunofluorescence, lcsh:R, medicine.disease, HE, hepatic encephalopathy, MSO, L-methionine-S-sulfoximine, Rats, 030104 developmental biology, Astrocytes, Lysosomes, Reactive Oxygen Species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464436083ac4c4e9e420c1a64df0fc74Test
http://www.sciencedirect.com/science/article/pii/S2352396419306401Test

المؤلفون: Shu-Qin Yu, Shuang-Lin Chen, Ling-Yuan Guo, Robert J. Lee, Shan-Shan Qi, Shu-Zhen Yan

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 279-293 (2019)

مصطلحات موضوعية: MMP, mitochondrial membrane potential, Cell, FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, CLSM, confocal laser scanning confocal microscopy, ECL, enhanced chemiluminescence, Mitochondrion, Photodynamic therapy, chemistry.chemical_compound, IKK, IκB kinase complex, 0302 clinical medicine, Cytotoxic T cell, OCR, oxygen consumption rate, General Pharmacology, Toxicology and Pharmaceutics, DMEM, Dulbecco׳s modified Eagle׳s medium, 0303 health sciences, z-VAD-fmk, z-Val-Ala-Asp-fluoromethylketone, HRP, horseradish peroxidase, TEM, transmission electron microscope, iTRAQ, isobaric tag for relative and absolute quantitation, SCX, strong cation exchange, Phosphatidylserine, Cell biology, medicine.anatomical_structure, PDT, photodynamic therapy, Hypocrellin A, 030220 oncology & carcinogenesis, DNA fragmentation, Original article, FDR, false discovery rate, PS, photosensitizer, MPT, mitochondrial permeability transition, PI, propidium iodide, TFA, trifluoroacetic acid, HA, hypocrellin A, 03 medical and health sciences, DCFH-DA, 2′,7′-dichlorofuorescin diacetate, ROS, reactive oxygen species, LC–MS/MS, Dox, doxorubicin, medicine, TCM, traditional Chinese medicinal, GO, gene ontology, 030304 developmental biology, z-IETD-fmk, z-Ile-Glu-Asp-fluoromethylketone, A549 cell, lcsh:RM1-950, Proteomic, NAC, N-acetyl-l-cysteine, JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-benzimidazolcarbocyanine iodide, ACN, acetonitrile, z-LEHD-fmk, z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethylketone, lcsh:Therapeutics. Pharmacology, iTRAQ, chemistry, Apoptosis, Cancer cell, UA, urea, IAA, iodoacetamide, Reactive oxygen species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234a255e7495bc3248845012723dbc6eTest
https://doi.org/10.1016/j.apsb.2018.12.004Test

المؤلفون: Zhimin Yin, Qiyun Hang, Yang Yang, Lan Luo, Peng Cao, Xiaoliang Dong, Ling Li, Yuan Fang

المصدر: Redox Biology, Vol 20, Iss, Pp 157-166 (2019)
Redox Biology

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, iNOS, inducible nitric oxide synthases, Clinical Biochemistry, Anti-Inflammatory Agents, Intracellular Space, γ-GT, γ-glutamyltranspeptidase, Pharmacology, medicine.disease_cause, TNF-α, tumor necrosis factor-α, Biochemistry, Mice, chemistry.chemical_compound, 0302 clinical medicine, N-acetyl-L-cysteine, GSH, glutathione, LPS, Lipopolysaccharide, Nrf2, nuclear factor-erythroid 2-related factor, lcsh:QH301-705.5, NF-κB, nuclear factor-kappa B, NAC, N-acetyl-L-cysteine, chemistry.chemical_classification, lcsh:R5-920, biology, NF-kappa B, Dipeptides, COX-2, prostaglandin H2 synthase, Glutathione, Glutathione synthetase, CLP, cecal ligation and puncture, Tumor necrosis factor alpha, medicine.symptom, lcsh:Medicine (General), Research Paper, NF-E2-Related Factor 2, Inflammation, HMGB1, Models, Biological, Nitric oxide, 03 medical and health sciences, ROS, reactive oxygen species, CHX, cycloheximide, Sepsis, medicine, Animals, NO, nitric oxide, Reactive oxygen species, IL-1β, interleukin-1 beta, Organic Chemistry, GCL, γ-glutamylcysteine ligase, γ-glutamylcysteine, HMGB1, high mobility group box 1, Disease Models, Animal, Oxidative Stress, RAW 264.7 Cells, 030104 developmental biology, GSS, glutathione synthetase, chemistry, lcsh:Biology (General), γ-GC, γ-glutamylcysteine, biology.protein, Reactive Oxygen Species, 030217 neurology & neurosurgery, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae683ecc0cc66bb2849c7654b0119182Test
http://www.sciencedirect.com/science/article/pii/S221323171830836XTest

المؤلفون: Binxiang Cai, Chunyan Liao, Danxue He, Jingmeng Chen, Jiahuai Han, Jiaying Lu, Kaiqi Qin, Wenxu Liang, Xiaoling Wu, Zuguo Liu, Yalin Wu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: p-MLKL, phosphorylated mixed lineage kinase domain-like protein, genetic structures, RIP3, receptor interacting protein kinase 3, ONL, outer nuclear layer, IS, inner segment, Biochemistry, Mice, Stargardt Disease, GSDME, gasdermin E, PCD, programmed cell death, AMD, age-related macular degeneration, qRT–PCR, quantitative real-time PCR, c-Jun N-terminal kinase, reactive oxygen species, LDH, lactate dehydrogenase, Caspase 3, pyroptosis, gasdermin E, apoptosis, RDH8, all-trans-retinol dehydrogenase 8, JNK, c-Jun N-terminal kinase, Retinaldehyde, Stargardt's disease, HMGB1, high-mobility group box 1, Research Article, PARP, poly-ADP-ribose polymerase, Pore Forming Cytotoxic Proteins, RPE, retinal pigment epithelium, GSDME-N, N-terminal fragment of GSDME, IgG, immunoglobulin G, STGD1, Stargardt's disease 1, Retina, atROL, all-trans-retinol, cDNA, complementary DNA, ROS, reactive oxygen species, Animals, Photoreceptor Cells, TEM, transmission electron microscopy, age-related macular degeneration, Molecular Biology, Nec-1, necrostatin-1, NAC, N-acetyl-l-cysteine, Cell Biology, photoreceptor, eye diseases, ABCA4, ABC (subfamily A, member 4) transporter, atRAL, all-trans-retinal, Cyt c, cytochrome c, ATP-Binding Cassette Transporters, sense organs, OS, outer segment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b29afe488a258683562e75a6793061Test
https://doi.org/10.1016/j.jbc.2021.101553Test

المؤلفون: Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez, Maria Garcia-Garrote, Juan A. Parga, Jannette Rodriguez-Pallares

المصدر: Data in Brief, Vol 21, Iss, Pp 934-942 (2018)
Data in Brief

مصطلحات موضوعية: 0301 basic medicine, Redox signaling, HMOX1, Dopaminergic, AT2, angiotensin type 2 receptor, 030105 genetics & heredity, medicine.disease_cause, lcsh:Computer applications to medicine. Medical informatics, NRF2, AT1, angiotensin type 1 receptor, 03 medical and health sciences, KLF9, Kruppel like factor 9, ROS, reactive oxygen species, Dopaminergic Cell, medicine, Viability assay, lcsh:Science (General), chemistry.chemical_classification, Hydroxydopamine, Reactive oxygen species, Multidisciplinary, 6-OHDA, 6-hydroxydopamine, AngII, angiotensin II, KLF9, Hmox1, heme oxygenase 1, Angiotensin II, pLV-KLF9, pLV-SV40-KLF9-puro, Cell biology, NRF2, nuclear factor-E2-related factor 2, Heme oxygenase, DCFDA, 2′,7′-dichlorofluorescin-diacetate, MTT, methylthiazolyldiphenyl-tetrazolium, pLV-empty, pLV-SV40-puro, chemistry, Oxidative stress, H2O2, hydrogen peroxide, lcsh:R858-859.7, Renin-angiotensin system, NAC, N-Acetyl-L-Cysteine, Neuroscience, Nqo1, NAD(P)H quinone dehydrogenase 1, lcsh:Q1-390

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ebbddad964eaad83783979874a52c5Test
http://www.sciencedirect.com/science/article/pii/S2352340918312861Test