دورية أكاديمية
Subclinical TRAPS treated with canakinumab
| العنوان: | Subclinical TRAPS treated with canakinumab |
|---|---|
| المؤلفون: | M. Amatruda, N.S. Carucci, C. Fede, G. Conti |
| المصدر: | Reumatismo, Vol 73, Iss 2 (2021) |
| بيانات النشر: | PAGEPress Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Internal medicine |
| مصطلحات موضوعية: | TRAPS, IL-1, canakinumab, AA amyloidosis., Medicine, Internal medicine, RC31-1245 |
| الوصف: | Tumor necrosis factor receptor–associated periodic syndrome (TRAPS) is a rare autoinflammatory disease characterized by recurrent episodes of fever and systemic inflammation. We describe the case of a 19-year-old patient who was referred to our attention with frequent subclinical TRAPS episodes characterized by mild arthralgias and crampy abdominal pain, without fever. Inflammatory markers, including serum amyloid A which increases the risk of long-term amyloidosis, were persistently high also when the patient was in good general conditions. Therapy with human anti-interleukin 1β monoclonal antibody, canakinumab, led to disease control and normalization of the inflammatory markers, which are currently still normal. This clinical case supports the need to treat also subclinical TRAPS. In this respect, canakinumab is effective and reduces the risk of developing amyloidosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Italian |
| تدمد: | 0048-7449 2240-2683 |
| العلاقة: | https://reumatismo.org/index.php/reuma/article/view/1406Test; https://doaj.org/toc/0048-7449Test; https://doaj.org/toc/2240-2683Test |
| DOI: | 10.4081/reumatismo.2021.1406 |
| الوصول الحر: | https://doaj.org/article/bb60fb069ea445b99c5e8e720f1beafaTest |
| رقم الانضمام: | edsdoj.bb60fb069ea445b99c5e8e720f1beafa |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00487449 22402683 |
|---|---|
| DOI: | 10.4081/reumatismo.2021.1406 |