المؤلفون: Machado, Mariana Filipa Pereira

مصطلحات موضوعية: DMJ, Ataxina-3 mutante, shRNA, Terapia celular, NESC derivadas de iPSC, MJD, mutant ataxin-3, Cell-based therapies, iPSC-derived NESC

الإتاحة: http://hdl.handle.net/10316/106385Test

المؤلفون: Vinhas, Ana Catarina Paulino do Ó

مصطلحات موضوعية: DMJ, ataxina-3 mutante, shRNA, iPSC derivadas de NESC, imunossupressão de modelo de murganho da DMJ, MJD, mutant ataxin-3, iPSC-derived NESC, immunosuppression of MJD mouse model

الإتاحة: http://hdl.handle.net/10316/94008Test

المؤلفون: Fernandes, Vanessa Alexandra Castanheira

مصطلحات موضوعية: Doença de Machado-Joseph, ataxina-3 mutante, NESC derivadas de iPSC, transplante celular, efeitos neuroprotetores, Machado-Joseph disease, mutant ataxin-3, iPSC-derived NESC, cell transplantation, neuroprotective effects

الإتاحة: http://hdl.handle.net/10316/88048Test

المؤلفون: Barros, Maria Inês Veiga de Almeida

مصطلحات موضوعية: Doenças Machado-Joseph, Células mesenquimatosas do estroma, Meio condicionado derivado de MSC, Vesiculas extracelulares, Níveis de ataxina-3 mutante, Machado-Joseph disease, Mesenchymal stromal cells, MSC-derived conditioned medium, Extracellular vesicles, Mutant ataxin-3 levels

الإتاحة: http://hdl.handle.net/10316/86421Test

المؤلفون: Henriques, Daniel Alexandre Sousa

مصطلحات موضوعية: Ataxia espinocerebelosa do tipo 3 (SCA3), ataxina-3 mutante, NESCs, iPSCs, Transplantação, Spinocerebellar ataxia type 3 (SCA3), Mutant Ataxin-3, Transplantation

الإتاحة: http://hdl.handle.net/10316/86142Test

المؤلفون: Moreira, Ricardo Gomes

مصطلحات موضوعية: SCA3, Ataxina-3 mutante, NESCs derivadas de iPSCs, Vesículas Extracelulares, Disseminação, Mutant Ataxin-3, iPSCs-derived NESCs, Extracellular Vesicles, Spreading

الإتاحة: http://hdl.handle.net/10316/84615Test

المؤلفون: Nobrega, Clevio, Mendonca, Liliana, Marcelo, Adriana, Lamaziere, Antonin, Tome, Sandra, Despres, Gaetan, Matos, Carlos A., Mechmet, Fatich, Langui, Dominique, den Dunnen, Wilfred, de Almeida, Luis Pereira, Cartier, Nathalie, Alves, Sandro

المصدر: Nobrega , C , Mendonca , L , Marcelo , A , Lamaziere , A , Tome , S , Despres , G , Matos , C A , Mechmet , F , Langui , D , den Dunnen , W , de Almeida , L P , Cartier , N & Alves , S 2019 , ' Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia ' , Acta Neuropathologica , vol. 138 , no. 5 , pp. 837-858 . https://doi.org/10.1007/s00401-019-02019-7Test

مصطلحات موضوعية: Ataxia, Cholesterol metabolism, 24-Cholesterol hydroxylase, Autophagy, SCA animal models, SCA patients, MACHADO-JOSEPH-DISEASE, DOMINANT CEREBELLAR-ATAXIA, MUTANT ATAXIN-3, RAT MODEL, 24-HYDROXYLASE, GENE, CYP46A1, REPEAT, NEURODEGENERATION, ABNORMALITIES

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/34b150bd-a456-4cd4-958d-870acd2e061bTest

الإتاحة: https://doi.org/10.1007/s00401-019-02019-7Test
https://hdl.handle.net/11370/34b150bd-a456-4cd4-958d-870acd2e061bTest
https://research.rug.nl/en/publications/34b150bd-a456-4cd4-958d-870acd2e061bTest
https://pure.rug.nl/ws/files/118606987/N_brega2019_Article_RestoringBrainCholesterolTurno.pdfTest

المؤلفون: Marcelo, Adriana, Brito, Filipa, Carmo-Silva, Sara, Matos, Carlos A., Alves-Cruzeiro, Joao, Vasconcelos-Ferreira, Ana, Koppenol, Rebekah, Mendonca, Liliana, de Almeida, Luis Pereira, Nóbrega, Clévio

مصطلحات موضوعية: Mutant Ataxin-3, Rat Model, Protein, Neuropathology, Hepatotoxicity

العلاقة: info:eu-repo/grantAgreement/EC/H2020/952422/EU; http://hdl.handle.net/10400.1/14482Test

الإتاحة: https://doi.org/10.1093/hmg/ddy328Test
http://hdl.handle.net/10400.1/14482Test

المؤلفون: Matos, C, Nóbrega, C, Louros, S, Almeida, B, Ferreiro, E, Valero, J, Almeida, L, Macedo-Ribeiro, S, Carvalho, A

المساهمون: Instituto de Investigação e Inovação em Saúde

مصطلحات موضوعية: Machado-joseph-disease, Protein ataxin-3, Polyglutamine disease, Mutant ataxin-3, Rat model, Huntingtin phosphorylation, Clinical-features, Expanded ataxin-3, Repeat expansion, Transgenic mice

وصف الملف: application/pdf; text/plain

العلاقة: info:eu-repo/grantAgreement/FCT/SFRH/SFRH/BD/47160/2008/PT; info:eu-repo/grantAgreement/FCT/SFRH/SFRH/BPD/70783/2010/PT; Journal of Cell Biology, vol. 212 (4), p. 465-480; http://jcb.rupress.org/content/212/4/465Test; http://hdl.handle.net/10216/108249Test

الإتاحة: https://doi.org/10.1083/jcb.201506025Test
http://hdl.handle.net/10216/108249Test

المؤلفون: Ana Vasconcelos-Ferreira, Filipa Brito, Liliana Mendonça, Carlos A. Matos, Luís Pereira de Almeida, Rebekah Koppenol, Clévio Nóbrega, Sara Carmo-Silva, Adriana Marcelo, João Alves-Cruzeiro

المصدر: Human Molecular Genetics
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: Male, Genetically modified mouse, Mutant, Mice, Transgenic, Nerve Tissue Proteins, Rat Model, Mice, 03 medical and health sciences, chemistry.chemical_compound, Trinucleotide Repeats, Ubiquitin, Autophagy, Mutant Ataxin-3, Genetics, medicine, Animals, Phosphorylation, Ataxin-3, Molecular Biology, Neuropathology, Genetics (clinical), 0303 health sciences, Deoxyadenosines, Cordycepin, biology, Protein, Adenylate Kinase, Hepatotoxicity, 030305 genetics & heredity, Nuclear Proteins, AMPK, Machado-Joseph Disease, General Medicine, Polyglutamine tract, medicine.disease, 3. Good health, Mice, Inbred C57BL, Repressor Proteins, Disease Models, Animal, chemistry, Cancer research, biology.protein, Machado–Joseph disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026495d499dd84b9cf58cb1f34f2a7abTest
https://doi.org/10.1093/hmg/ddy328Test