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1دورية أكاديمية
المؤلفون: Liqi He, Meng Yao Zhang, Matthew Cox, Qian Zhang, Andrew F. Donnell, Yong Zhang, Christine Tarby, Patrice Gill, Murugaiah A. M. Subbaiah, Thangeswaran Ramar, Maheswara Reddy, Vijaya Puttapaka, Yi-Xin Li, Prasanna Sivaprakasam, David Critton, Dawn Mulligan, Chunshan Xie, Radha Ramakrishnan, Jignesh Nagar, Shailesh Dudhgaonkar, Anwar Murtaza, Martins S. Oderinde, Gary L. Schieven, Arvind Mathur, Ashvinikumar V. Gavai, Gregory Vite, Sanjeev Gangwar, Yam B. Poudel
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, synergistic antitumor activity, promising therapeutic agents, phenylpiperidine side chain, gathered considerable interest, novel tlr7 agonists, adme properties culminated, 14 b, vivo <, like properties, 7 agonists, suggesting opportunities, pharmacodynamic profiles, oncology therapies, like receptor, favorable drug, demonstrated excellent, cancer immunotherapy, apd1 antibody, additional refinement
الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00456.s001Test
https://figshare.com/articles/journal_contribution/Identification_and_Optimization_of_Small_Molecule_Pyrazolopyrimidine_TLR7_Agonists_for_Applications_in_Immuno-oncology/24968292Test -
2دورية أكاديمية
المؤلفون: Yam B. Poudel, Liqi He, Matthew Cox, Qian Zhang, Walter L. Johnson, Qiang Cong, Heng Cheng, Naidu S. Chowdari, Christine Tarby, Andrew F. Donnell, Matthais Broekema, Daniel P. O’Malley, Yong Zhang, Murugaiah A. M. Subbaiah, Boda Vijay Kumar, Lakshumanan Subramani, Bei Wang, Yi-Xin Li, Prasanna Sivaprakasam, David Critton, Dawn Mulligan, Bhupindar Sandhu, Chunshan Xie, Radha Ramakrishnan, Jignesh Nagar, Shailesh Dudhgaonkar, Martins S. Oderinde, Anwar Murtaza, Gary L. Schieven, Arvind Mathur, Ashvinikumar V. Gavai, Gregory Vite, Sanjeev Gangwar
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, mouse whole blood, complete tumor regression, 26 tumor model, based reporter assay, selective tlr7 agonists, novel tlr7 agonists, tlr7 agonists, developed novel, based designs, vitro <, tnfα cytokines, systemic agent, significant secretion, pharmacodynamic studies, mice showed, intravenous route
الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00455.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Novel_TLR7_Agonists_as_Systemic_Agent_for_Combination_With_aPD1_for_Use_in_Immuno-oncology/24961448Test -
3
المصدر: Green Chemistry. 25:2368-2377
مصطلحات موضوعية: Environmental Chemistry, Pollution
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::74e6b88ca59caa1967db027d43ab5425Test
https://doi.org/10.1039/d2gc04607eTest -
4دورية أكاديمية
المؤلفون: Subba Rao Polimera (11473882), Murugaiah A. M. Subbaiah (11473885), Andivelu Ilangovan (1600051)
مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Biotechnology, Ecology, Immunology, Developmental Biology, Infectious Diseases, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, mild reaction conditions, fused heteroaryl systems, silyl enol ethers, palladium ( ii, arylethyl ) cyclohexa, ligand free palladium, 4 -( 2, external ligand, enol silanes, via <, synthetic precursors, synthetic applications, require either, provides access, open air, one derivatives, enolate pathway, cyclohexadienone products
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5
المصدر: The Journal of Organic Chemistry.
مصطلحات موضوعية: Organic Chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cd4b98e419d0b2015bda6099dfc0eb2dTest
https://doi.org/10.1021/acs.joc.3c00502Test -
6
المصدر: The Journal of Organic Chemistry. 87:14778-14792
مصطلحات موضوعية: Carbodiimides, Alcohols, Organic Chemistry, Silanes, Palladium, Catalysis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f7b8fd5130aa467a525b6a3bda2b15Test
https://doi.org/10.1021/acs.joc.2c02107Test -
7
المؤلفون: Murugaiah A. M. Subbaiah, Nicholas A. Meanwell
المصدر: Journal of Medicinal Chemistry. 64:14046-14128
مصطلحات موضوعية: Drug, Molecular Structure, biology, Chemistry, media_common.quotation_subject, hERG, Stereoisomerism, Metabolic stability, Ring (chemistry), Combinatorial chemistry, Lead (geology), Drug Design, Drug Discovery, Lipophilicity, Benzene Derivatives, biology.protein, Molecular Medicine, Moiety, Pharmacophore, media_common
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ac2ef7ec0f24171683257ae23e25e5Test
https://doi.org/10.1021/acs.jmedchem.1c01215Test -
8
المصدر: The Journal of Organic Chemistry. 86:14356-14370
مصطلحات موضوعية: Silylation, Chemistry, Ligand, Organic Chemistry, Quinones, Regioselectivity, chemistry.chemical_element, Silanes, Alkylation, Ligands, Combinatorial chemistry, Enol, Catalysis, Quinone, chemistry.chemical_compound, Palladium
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a6b0bb652aaf601028f122be4258f3Test
https://doi.org/10.1021/acs.joc.1c00857Test -
9
المصدر: The Journal of organic chemistry. 87(21)
مصطلحات موضوعية: Molecular Structure, Organic Chemistry, Ketones, Copper, Catalysis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99501ed7cfad9a7267b0dea82a0aeb5fTest
https://pubmed.ncbi.nlm.nih.gov/36190309Test -
10
المؤلفون: Murugaiah, A M Subbaiah, Lakshumanan, Subramani, Thangeswaran, Ramar, Salil, Desai, Sarmistha, Sinha, Sandhya, Mandlekar, John F, Kadow, Susan, Jenkins, Mark, Krystal, Murali, Subramanian, Srikanth, Sridhar, Shweta, Padmanabhan, Priyadeep, Bhutani, Rambabu, Arla, Nicholas A, Meanwell
المصدر: Journal of medicinal chemistry. 65(16)
مصطلحات موضوعية: Drug Delivery Systems, Atazanavir Sulfate, Animals, Prodrugs, Amines, Amino Acids, Rats
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::e708bfe7b3076c0aafd6bdaec770723aTest
https://pubmed.ncbi.nlm.nih.gov/35952307Test