المؤلفون: Maren Heimhalt (3349772), Pallavi Mukherjee (11681018), Ryan A. Grainger (10509637), Robert Szabla (7464806), Christopher Brown (258061), Rebecca Turner (1388115), Murray S. Junop (253521), Paul J. Berti (2056342)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Plant Biology, Virology, Chemical Sciences not elsewhere classified, providing new avenues, crystal structures showed, 2 kcal mol, 08 mg ml, 77 ± 0, 21 ± 0, typical good inhibitor, screen inhibitor fragments, tfp semicarbazone prevented, shikimate biosynthetic pathway, active site relative, 7 kcal mol, growth inhibition occurred, 50 , dahp synthase inhibition, shikimate pathway, active site, growth inhibition, synthase catalyzes

العلاقة: https://figshare.com/articles/journal_contribution/An_Inhibitor-in-Pieces_Approach_to_DAHP_Synthase_Inhibition_Potent_Enzyme_and_Bacterial_Growth_Inhibition/16989479Test

الإتاحة: https://doi.org/10.1021/acsinfecdis.1c00462.s001Test

المؤلفون: Murray S Junop

المصدر: Annals of Experimental and Molecular Biology. 4:1-9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::340d1e99df02bca290144e1ee400c28bTest
https://doi.org/10.23880/aemb-16000111Test

المؤلفون: Robert Szabla, Paul J. Berti, Christopher M. Brown, Murray S. Junop, Pallavi Mukherjee, Maren Heimhalt, Rebecca Turner, Ryan A. Grainger

المصدر: ACS Infectious Diseases. 7:3292-3302

مصطلحات موضوعية: Stereochemistry, DAHP synthase, 010402 general chemistry, 01 natural sciences, Phosphates, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Escherichia coli, Aromatic amino acids, Shikimate pathway, 3-Deoxy-7-Phosphoheptulonate Synthase, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, ATP synthase, Chemistry, Active site, Oxime, 0104 chemical sciences, Kinetics, Infectious Diseases, Enzyme, biology.protein, Growth inhibition

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc14e474bc5a16e6b2ed5d3f9a528b8dTest
https://doi.org/10.1021/acsinfecdis.1c00462Test

المؤلفون: Cameron Rzadki, Simon Huang, Murray S. Junop, Ryan A. Grainger, Beverlee Buzon

المصدر: ACS Omega
ACS Omega, Vol 6, Iss 14, Pp 9352-9361 (2021)

مصطلحات موضوعية: Exonuclease, DNA damage, General Chemical Engineering, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Cytotoxicity, QD1-999, 030304 developmental biology, Cisplatin, 0303 health sciences, Nuclease, biology, Chemistry, General Chemistry, Small molecule, 3. Good health, Biochemistry, 030220 oncology & carcinogenesis, Toxicity, biology.protein, DNA, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0520ebea5315673fd74e17cbd10c1870Test
https://doi.org/10.1021/acsomega.0c03528Test

المؤلفون: Michael Geiger, Louisa Wilcke, Paul-Christian Burda, Christopher M. Brown, Kun Zhang, Jan Stephan Wichers, Jan Strauss, Tim W. Gilberger, Dorothee Heincke, Benjamin Liffner, Sarah Lemcke, Roland Thuenauer, Christian Löw, Danny W. Wilson, Samuel Pazicky, Michael Filarsky, Anna Bachmann, Andrés Lill, Murray S. Junop

المصدر: Journal of Molecular Biology. 432:878-896

مصطلحات موضوعية: Molecular Sequence Data, Plasmodium falciparum, Protozoan Proteins, Parasitemia, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Organelle, medicine, Animals, Humans, Secretion, Amino Acid Sequence, Molecular Biology, Phylogeny, 030304 developmental biology, Armadillo Domain Proteins, 0303 health sciences, Rhoptry, Plasmodium (life cycle), biology, Chemistry, biology.organism_classification, Malaria, 3. Good health, Cell biology, Protein Transport, Red blood cell, medicine.anatomical_structure, Mutagenesis, Biotinylation, Mutation, biology.protein, Protein A, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b2d61d71ff76fa5705fd239e6640f1Test
https://doi.org/10.1016/j.jmb.2019.12.024Test

المؤلفون: Christopher M. Brown, Michael Vu, Murray S. Junop, Marc Laforet, David R. Edgell, Kun Zhang, Thomas A McMurrough, Gregory B. Gloor

المصدر: Nucleic Acids Research

مصطلحات موضوعية: Computational biology, Plasma protein binding, Cleavage (embryo), Homing endonuclease, Substrate Specificity, Evolution, Molecular, 03 medical and health sciences, Endonuclease, Genetics, Protein–DNA interaction, Amino Acid Sequence, 030304 developmental biology, 0303 health sciences, biology, Base Sequence, Nucleic Acid Enzymes, 030302 biochemistry & molecular biology, DNA, Directed evolution, Endonucleases, A-site, Amino Acid Substitution, Meganuclease, Mutation, biology.protein, Nucleic Acid Conformation, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd9c3a14d50116587d2f6e98fab2ef1Test
http://europepmc.org/articles/PMC6847045Test

المؤلفون: Paul J. Berti, Murray S. Junop, Vladimir Popović, Adam Z Rosanally, Robert Szabla, Alexander W Senson, Naresh Balachandran, Edward Morrison

المصدر: Biochemistry. 58:4236-4245

مصطلحات موضوعية: Time Factors, Stereochemistry, Genetic Vectors, Neisseria meningitidis, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Tetrahedral carbonyl addition compound, Catalytic Domain, Oximes, Transferase, 3-Deoxy-7-Phosphoheptulonate Synthase, Aldehyde-Lyases, 030304 developmental biology, 0303 health sciences, biology, Oxo-Acid-Lyases, Active site, Substrate (chemistry), Sialic acid synthase, Ligand (biochemistry), Oxime, N-Acetylneuraminic Acid, 0104 chemical sciences, Dissociation constant, Kinetics, chemistry, biology.protein, Crystallization, Protein Binding, Triose-Phosphate Isomerase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9303de14caa77ffb9066cfafe39a5f2Test
https://doi.org/10.1021/acs.biochem.9b00654Test

المؤلفون: Alba Guarné, Monica C. Pillon, J. Pablo Radicella, Mac C.Y. Mok, Anna Campalans, Murray S. Junop

المساهمون: Laboratoire de Recherche sur l'Instabilité Génétique (LRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Biochemistry and Biomedical Sciences, McMaster University [Hamilton, Ontario], Institute of Cellular and Molecular Radiobiology

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-39543-1⟩

مصطلحات موضوعية: 0301 basic medicine, DNA Repair, DNA damage, DNA repair, lcsh:Medicine, CHO Cells, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Plasma protein binding, Article, 03 medical and health sciences, XRCC1, chemistry.chemical_compound, Cricetulus, 0302 clinical medicine, Protein Domains, Escherichia coli, Animals, Humans, DNA Breaks, Single-Stranded, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], lcsh:Science, ComputingMilieux_MISCELLANEOUS, Binding selectivity, Multidisciplinary, lcsh:R, DNA, DNA-binding domain, Cell biology, X-ray Repair Cross Complementing Protein 1, 030104 developmental biology, BRCT domain, chemistry, lcsh:Q, 030217 neurology & neurosurgery, HeLa Cells, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed351f37297168fb4054c0b41f0ed71Test
http://link.springer.com/article/10.1038/s41598-019-39543-1Test

المؤلفون: Thomas A McMurrough, Christopher M Brown, Kun Zhang, Georg Hausner, Murray S Junop, Gregory B Gloor, David R Edgell

المصدر: Nucleic Acids Research

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, alpha-Helical, Genetic Vectors, Gene Expression, Crystallography, X-Ray, Protein Engineering, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Catalytic Domain, Genetics, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Cloning, Molecular, DNA Cleavage, Base Sequence, Nucleic Acid Enzymes, DNA, Endonucleases, Recombinant Proteins, Kinetics, 030104 developmental biology, Amino Acid Substitution, Thermodynamics, 030217 neurology & neurosurgery, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ca9be2125ada18cd6db5c856beabb6Test
http://europepmc.org/articles/PMC6294521Test

المؤلفون: Murray S. Junop, Ryan A. Grainger, Simon Huang, Cameron Rzadki, Beverlee Buzon

المصدر: Nucleic Acids Research

مصطلحات موضوعية: DNA Replication, 0301 basic medicine, Exonuclease, DNA Repair, Oligonucleotides, DNA, Single-Stranded, Gene Expression, Cell Cycle Proteins, Interstrand crosslink, Saccharomyces cerevisiae, 03 medical and health sciences, Endonuclease, chemistry.chemical_compound, Transcription (biology), Cleave, ICL repair, Escherichia coli, Genetics, Humans, Pyrroles, A-DNA, Cloning, Molecular, Base Pairing, Benzodiazepinones, Base Sequence, biology, Nucleic Acid Enzymes, Recombinant Proteins, Cell biology, Cross-Linking Reagents, Exodeoxyribonucleases, 030104 developmental biology, chemistry, biology.protein, Nucleic Acid Conformation, DNA, DNA Damage, Plasmids

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092f86883a923a6feb20e0be366bd8e7Test
https://doi.org/10.1093/nar/gky759Test