دورية أكاديمية
Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy
| العنوان: | Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy |
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| المؤلفون: | Ghassabian, A. (Akhgar), Pierotti, L. (Livia), Basterrechea, M. (Mikel), Chatzi, L. (Leda), Estarlich, M. (Marisa), Fernández-Somoano, A. (Ana), Fleisch, A.F. (Abby F.), Gold, D.R. (Diane), Julvez, J. (Jordi), Karakosta, P. (Polyxeni), Lertxundi, A. (Aitana), Lopez-Espinosa, M.-J. (Maria-Jose), Mulder, T.A. (Tessa A.), Korevaar, T.I.M. (Tim), Oken, E. (Emily), Peeters, R.P. (Robin), Rifas-Shiman, S.L. (Sheryl), Stephanou, E.G. (Euripides), Tardón, A. (Adonina), Tiemeier, H.W. (Henning), Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Sunyer, J. (Jordi), Guxens Junyent, M. (Mònica) |
| المصدر: | JAMA network open vol. 2 no. 10 |
| سنة النشر: | 2019 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| الوصف: | Importance: Air pollutants interact with estrogen nuclear receptors, but their effect on thyroid signaling is less clear. Thyroid function is of particular importance for pregnant women because of the thyroid's role in fetal brain development. Objective: To determine the short-term association of exposure to air pollution in the first trimester with thyroid function throughout pregnancy. Design, Setting, and Participants: In this cohort study, 9931 pregnant women from 4 European cohorts (the Amsterdam Born Children and Their Development Study, the Generation R Study, Infancia y Medio Ambiente, and Rhea) and 1 US cohort (Project Viva) with data on air pollution exposure and thyroid function during pregnancy were included. The recruitment period for the Amsterdam Born Children and Their Development Study was January 2003 to March 2004; for Generation R, April 2002 to January 2006; for Infancia y Medio Ambiente, November 2003 to January 2008; for Rhea, February 2007 to February 2008; and for Project Viva, April 1999 to November 2002. Statistical analyses were conducted from January 2018 to April 2019. Main Outcomes and Measures: Residential air pollution concentrations (ie, nitrogen oxide and particulate matter [PM]) during the first trimester of pregnancy were estimated using land-use regression and satellite-derived aerosol optical depth models. Free thyroxine, thyrotropin, and thyroid peroxidase antibody levels were measured across gestation. Hypothyroxinemia was defined as free thyroxine below the fifth percentile of the cohort distribution w |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/120320Test; urn:hdl:1765/120320 |
| DOI: | 10.1001/jamanetworkopen.2019.12902 |
| الإتاحة: | https://doi.org/10.1001/jamanetworkopen.2019.12902Test http://repub.eur.nl/pub/120320Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.12DB24BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamanetworkopen.2019.12902 |
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