Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study
| العنوان: | Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study |
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| المؤلفون: | Shahid Bashir, Fahad D. Alosaimi, Fahad Albader, Jamaan Alghamdi, Abdullah Abu Jamea, Muhammed Alblowi |
| المصدر: | Journal of Clinical Imaging Science Journal of Clinical Imaging Science, Vol 9, Iss 1, Pp 1-1 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.diagnostic_test, business.industry, Putamen, lcsh:R895-920, shape analysis, Magnetic resonance imaging, 030227 psychiatry, Left thalamus, schizophrenia, 03 medical and health sciences, 0302 clinical medicine, Right hippocampus, Brain structure, Medicine, Radiology, Nuclear Medicine and imaging, In patient, Original Article, Mr images, business, Nuclear medicine, 030217 neurology & neurosurgery, high-resolution magnetic resonance imaging, Shape analysis (digital geometry) |
| الوصف: | Objective: Investigation of brain structure in disease has been enhanced by developments in shape analysis methods that can identify subtle regional surface distortions. High-resolution magnetic resonance (MR) imaging was used to compare volumetric and shape analysis in schizophrenia (SCZ) patients and healthy controls (CON). Methods: T1-weighted, 1-mm thick MR images were acquired for 15 patients with SCZ and 15 age-matched healthy controls using subcortical volume and shape analysis, which we believe to be complimentary to volumetric measures. Results: SCZ patients showed significant shape differences compared to healthy controls in the right hippocampus (P < 0.005), left and right putamen (P < 0.044 and P < 0.031), left caudate (P < 0.029), right pallidum (P < 0.019), and left thalamus (P < 0.033). Conclusion: Our results provide evidence for subcortical neuroanatomical changes in patients with SCZ. Hence, shape analysis may aid in the identification of structural biomarkers for identifying individuals of SCZ. |
| تدمد: | 2156-7514 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5ae2ecae5fc3b6df6a4a42a9e198f7Test https://pubmed.ncbi.nlm.nih.gov/30788185Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9a5ae2ecae5fc3b6df6a4a42a9e198f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21567514 |
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