دورية أكاديمية
Comparative Immunovirological and Clinical Responses to Antiretroviral Therapy Between HIV-1 Group O and HIV-1 Group M Infected Patients
| العنوان: | Comparative Immunovirological and Clinical Responses to Antiretroviral Therapy Between HIV-1 Group O and HIV-1 Group M Infected Patients |
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| المؤلفون: | Kouanfack, Charles, Unal, Guillemette, Schaeffer, Laura, Kfutwah, Anfumbom, Aghokeng, Avelin, Mougnutou, Rose, Tchemgui-Noumsi, Nathalie, Alessandri-Gradt, Elodie, Delaporte, Eric, Simon, Francois, Vray, Muriel, Plantier, Jean-Christophe, Alima, Michèle, Essengué, Lucie, Mounpou, Georges, Ngang, Peter, Ngoma, Pauline, Omgba, Vincent, Omam, Deborah, Tonfack, Léonie, Zé, Flore, Akongnwi, Emmanuel, Dumortier, Jérôme, Ngoupo, Paul-Alain, Njouom, Richard, Rousset, Dominique, Vessière, Aurélia, Fouler, Lenaig Le, Madec, Yoann, Bodelet, Marine, Dupre, Jean-Michel, Pavie, Juliette, Rekacewicz, Claire, Garcia, Paula, Colin, Géraldine |
| المساهمون: | Hôpital Central de Yaoundé Yaoundé, Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratoire de virologie Rouen, Hôpital Charles Nicolle Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I (UY1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Cheikh Anta Diop de Dakar Sénégal (UCAD), Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), DynaMo study group, Institut Pasteur Paris (IP), Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) |
| المصدر: | ISSN: 1058-4838. |
| بيانات النشر: | HAL CCSD Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | HIV-1 group O, cART, genetic diversity, immuno-virological response, MESH: HIV-1 group O, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| الوصف: | International audience ; BACKGROUND:Genetic divergence of HIV-1/O relative to HIV-1/M impacts virological monitoring and drug susceptibility, but little is known about impact on therapeutic outcomes. We aimed to determine if responses to standardized cART were similar between groups despite strain divergence.METHODS:We performed an open non-randomized study comparing the immunological, virological and clinical responses to cART based on 2NRTIs+1PI/r, in naive and paired HIV-1/O- versus HIV-1/M-infected patients (ratio 1:2), matched on sex, age, CD4 count, hemoglobin level, and HBsAg status. The primary endpoint was the proportion of patients with undetectable plasma viral load (pVL, threshold 60 cp/mL) at W48. Secondary endpoints were the proportion of patients with undetectable pVL at W24 and W96 and CD4 evolution between baseline and W24, W48 and W96.RESULTS:47 HIV-1/O and 94 HIV-1/M patients were included. Mean pVL at baseline was significantly lower by 1 log for HIV-1/O versus HIV-1/M patients. At W48, no significant difference was observed between populations with undetectable pVL in 80.9% of HIV-1/O versus 75.5% of HIV-1/M patients. Differences at W24 and W96 were not significant. A difference in CD4 gain was observed in favor of HIV-1/M at W48 and W96, but this was not significant when adjusted on both matched criteria and pVL at baseline.CONCLUSIONS:Our data demonstrate similar immuno-virological and clinical response between HIV-1/O and HIV-1/M patients, suggesting that genetic divergence does not impact therapeutic outcomes. They also reveal significantly lower baseline replication for HIV-1/O variants, suggesting specific virological properties and physiopathology that now need to be addressed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31063537; hal-02383168; https://normandie-univ.hal.science/hal-02383168Test; PUBMED: 31063537 |
| DOI: | 10.1093/cid/ciz371 |
| الإتاحة: | https://doi.org/10.1093/cid/ciz371Test https://normandie-univ.hal.science/hal-02383168Test |
| رقم الانضمام: | edsbas.FF4490EB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cid/ciz371 |
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