دورية أكاديمية
Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials
| العنوان: | Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials |
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| المؤلفون: | Heerspink, HL, Greene, T, Tighiouart, H, Gansevoort, RT, Coresh, J, Simon, AL, Chan, TM, Hou, FF, Lewis, JB, Locatelli, F, Praga, M, Schena, FP, Levey, AS, Inker, LA, Schrier, RW, Estacio, RO, Perkovic, V, Parving, H-H, Carlo, M, Zucchelli, P, Brenner, BM, Barret, B, Kamper, A-L, Strandgaard, S, Rodby, RA, Rohde, RD, Lewis, E, Wanner, C, von Eynatten, M, Katafuchi, R, de Jong, PE, van Essen, GG, Xie, D, Perrone, RD, Abebe, KZ, Li, P, Leung, CB, Szeto, CC, Chow, KM, Del Vecchio, L, Andrulli, S, Pozzi, C, Maes, B, Dwyer, J, Lachin, JM, Goicoechea, M, Verde, E, Caravaca, F, Gutierrez, E, Sevillano, A, Wetzels, JFM, Blankestijn, PJ, van Zuilen, AD, van den Brand, J, Beck, G, Kusek, J, Klahr, S, Montagnino, CP, Passerini, P, Moroni, G, Montogrino, G, Appel, GB, Frisch, G, Kobayashi, F, Makino, H, Ito, S, Imai, E, Ruggenenti, P, Remuzzi, G, De Zeeuw, D, Heerspink, HJL, Keane, W, Donadio, J, Fervenza, FC, Floege, J, Rauen, T, Fitzner, C, Hilgers, R-D, Hannedouche, TP, Toto, RD, Becker, GJ, Ihle, U, Kincaid-Smith, PS |
| المصدر: | The Lancet Diabetes & Endocrinology , 7 (2) pp. 128-139. (2019) |
| بيانات النشر: | ELSEVIER SCIENCE INC |
| سنة النشر: | 2019 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, STAGE RENAL-DISEASE, PROTEINURIA REDUCTION, NEPHROPATHY, REMISSION, EFFICACY, SAFETY, RISK |
| الوصف: | Background Change in albuminuria has strong biological plausibility as a surrogate endpoint for progression of chronic kidney disease, but empirical evidence to support its validity is lacking. We aimed to determine the association between treatment effects on early changes in albuminuria and treatment effects on clinical endpoints and surrograte endpoints, to inform the use of albuminuria as a surrogate endpoint in future randomised controlled trials. Methods In this meta-analysis, we searched PubMed for publications in English from Jan 1, 1946, to Dec 15, 2016, using search terms including “chronic kidney disease”, “chronic renal insufficiency”, “albuminuria”, “proteinuria”, and “randomized controlled trial”; key inclusion criteria were quantifiable measurements of albuminuria or proteinuria at baseline and within 12 months of follow-up and information on the incidence of end-stage kidney disease. We requested use of individual patient data from the authors of eligible studies. For all studies that the authors agreed to participate and that had sufficient data, we estimated treatment effects on 6-month change in albuminuria and the composite clinical endpoint of treated end-stage kidney disease, estimated glomerular filtration rate of less than 15 mL/min per 1·73 m2, or doubling of serum creatinine. We used a Bayesian mixed-effects meta-regression analysis to relate the treatment effects on albuminuria to those on the clinical endpoint across studies and developed a prediction model for the treatment effect on the clinical endpoint on the basis of the treatment effect on albuminuria. Findings We identified 41 eligible treatment comparisons from randomised trials (referred to as studies) that provided sufficient patient-level data on 29 979 participants (21 206 [71%] with diabetes). Over a median follow-up of 3·4 years (IQR 2·3–4·2), 3935 (13%) participants reached the composite clinical endpoint. Across all studies, with a meta-regression slope of 0·89 (95% Bayesian credible interval [BCI] 0·13–1·70), each 30% ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10090124/5/Chaturvedi%202020%20Change%20in%20albuminuria%20as%20a%20surrogate%20endpoint%20for%20progression%20of%20kidney%20disease.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10090124/10/Chaturvedi%202020%20Supplementary%20Change%20in%20albuminuria%20as%20a%20surrogate%20endpoint%20for%20progression%20of%20kidney%20disease.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10090124Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10090124/5/Chaturvedi%202020%20Change%20in%20albuminuria%20as%20a%20surrogate%20endpoint%20for%20progression%20of%20kidney%20disease.pdfTest https://discovery.ucl.ac.uk/id/eprint/10090124/10/Chaturvedi%202020%20Supplementary%20Change%20in%20albuminuria%20as%20a%20surrogate%20endpoint%20for%20progression%20of%20kidney%20disease.pdfTest https://discovery.ucl.ac.uk/id/eprint/10090124Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.67541976 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |