Pilot assessment of the effect of negative pressure wound therapy on microperfusion of chronic and acute wounds
| العنوان: | Pilot assessment of the effect of negative pressure wound therapy on microperfusion of chronic and acute wounds |
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| المؤلفون: | Werner Lang, Ulrich Rother, Alexander Meyer, Mona Theune |
| المصدر: | Clinical Hemorheology and Microcirculation. 79:455-462 |
| بيانات النشر: | IOS Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Chronic Limb-Threatening Ischemia, Male, Supine position, Physiology, Arterial disease, medicine.medical_treatment, Ischemia, 030204 cardiovascular system & hematology, Fasciotomy, Peripheral Arterial Disease, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Negative-pressure wound therapy, medicine, Humans, Prospective Studies, Wound Healing, business.industry, Hematology, Blood flow, medicine.disease, Single centre, Anesthesia, Female, Cardiology and Cardiovascular Medicine, business, Perfusion, Negative-Pressure Wound Therapy |
| الوصف: | BACKGROUND: Negative pressure wound therapy (NPWT) has been established over years for treatment of chronic and complex wounds. OBJECTIVE: Aim of this study was to investigate the effect NPWT on the microperfusion. METHODS: Prospective single centre analysis of patients treated with NPWT due to acute (ACUTE) wounds after fasciotomy or patients with chronic wounds (CHRONIC) due to a chronic limb threatening ischemia was performed. NPWT was conducted through a three days sequence with a negative pressure of –120 mmHg. Before after and during the entire period of therapy the microperfusion was assessed (O2C™, LEA Medizintechnik). RESULTS: Comparison of the perfusion values of 28 patients (CHRONIC/ACUTE 5/23, women/men 8/20) before and after the NPWT sequence showed a non-significant improvement in the CHRONIC group (supine position: p = 0.144, elevated position p = 0.068) and a significant decrease in the ACUTE group (supine position p = 0.012, elevated position p = 0.034). This effect could also been demonstrated during the NPWT over time (CHRONIC: supine position: p = 0.320, elevated position: p = 0.053, ACUTE: supine position: p = 0.021, elevated position: p = 0.012). CONCLUSION: Microperfusion measurements showed alterations and differences in wound bed perfusion of acute and chronic wounds; acute wounds tended to a decrease of blood flow, whereas this effect was not seen in chronic wounds in peripheral artery disease. |
| تدمد: | 1875-8622 1386-0291 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b761efb67de1d37670ccc3d89a4914edTest https://doi.org/10.3233/ch-211189Test |
| رقم الانضمام: | edsair.doi.dedup.....b761efb67de1d37670ccc3d89a4914ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758622 13860291 |
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