Prediction of bortezomib-induced peripheral neuropathy with the R–R interval variation of the electrocardiogram in plasma cell myeloma: a retrospective study
| العنوان: | Prediction of bortezomib-induced peripheral neuropathy with the R–R interval variation of the electrocardiogram in plasma cell myeloma: a retrospective study |
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| المؤلفون: | Masatomo Shimizu, Akihisa Imagawa, Yuki Kinoshita, Takuji Miyoshi, Toshikazu Akioka, Kazuki Tanabe, Taiji Yokote, Yui Arita, Tomoyuki Yamada, Yuki Masuda, Mitsuya Ueda, Jun Hatooka, Mayumi Fujimoto, Uta Nishiwaki, Kazuki Iwaki |
| المصدر: | Leukemia & Lymphoma. 61:707-713 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, animal structures, Antineoplastic Agents, Bortezomib, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Internal medicine, Plasma Cell Myeloma, Humans, Medicine, In patient, skin and connective tissue diseases, Retrospective Studies, urogenital system, business.industry, Peripheral Nervous System Diseases, Retrospective cohort study, Hematology, medicine.disease, R-R Interval, Peripheral neuropathy, 030220 oncology & carcinogenesis, Toxicity, Multiple Myeloma, business, 030215 immunology, medicine.drug |
| الوصف: | Bortezomib-induced peripheral neuropathy (BIPN) is a key dose-limiting toxicity in patients with plasma cell myeloma (PCM). This study examined 56 patients with PCM treated with bortezomib to determine the possible predisposing factors to BIPN with the R-R interval variation (RRIV) of the electrocardiogram (ECG). Of all, 17 patients developed Clinically obvious BIPN, grades 2-4 or grade worsening from the baseline neuropathy per the National Cancer Institute's Common Terminology Criteria for Adverse Events (v5.0). In the receiver operating characteristic curve analysis, the optimal RRIV cutoff value to distinguish patients with and without risk to develop BIPN was 1.391. A lower RRIV before bortezomib treatment independently correlated with the onset of Clinically obvious BIPN ( |
| تدمد: | 1029-2403 1042-8194 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31fda2cfe8f3b9eba37fc9c7c751e80Test https://doi.org/10.1080/10428194.2019.1678152Test |
| رقم الانضمام: | edsair.doi.dedup.....c31fda2cfe8f3b9eba37fc9c7c751e80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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