دورية أكاديمية
Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.
| العنوان: | Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. |
|---|---|
| المؤلفون: | Ferrufino-Schmidt, Maria C, Medeiros, L Jeffrey, Liu, Hui, Clemens, Mark W, Hunt, Kelly K, Laurent, Camille, Lofts, Julian, Amin, Mitual B, Ming Chai, Siaw, Morine, Angela, Di Napoli, Arianna, Dogan, Ahmet, Parkash, Vinita, Bhagat, Govind, Tritz, Denise, Quesada, Andres E, Pina-Oviedo, Sergio, Hu, Qinlong, Garcia-Gomez, Francisco J, Jose Borrero, Juan, Horna, Pedro, Thakral, Beenu, Narbaitz, Marina, Hughes, R Condon, Yang, Li-Jun, Fromm, Jonathan R, Wu, David, Zhang, Da, Sohani, Aliyah R, Hunt, John, Vadlamani, Indira U, Morgan, Elizabeth A, Ferry, Judith A, Szigeti, Reka, C Tardio, Juan, Granados, Rosario, Dertinger, Susanne, Offner, Felix A, Pircher, Andreas, Hosry, Jeff, Young, Ken H, Miranda, Roberto N |
| سنة النشر: | 2018 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Biopsy, Breast Implantation, Breast Implants, Breast Neoplasms, Diagnostic Errors, Female, Hodgkin Disease, Humans, Immunohistochemistry, Lymph Nodes, Lymphoma, Large-Cell, Anaplastic, Middle Aged, Predictive Value of Tests, Treatment Outcome |
| الوصف: | Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P=0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1532-0979 |
| العلاقة: | http://hdl.handle.net/10668/11865Test; PMC7500854; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500854Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500854/pdfTest |
| DOI: | 10.1097/PAS.0000000000000985 |
| الإتاحة: | https://doi.org/10.1097/PAS.0000000000000985Test http://hdl.handle.net/10668/11865Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500854Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500854/pdfTest |
| حقوق: | open access |
| رقم الانضمام: | edsbas.5CF0BBE6 |
| قاعدة البيانات: | BASE |
| تدمد: | 15320979 |
|---|---|
| DOI: | 10.1097/PAS.0000000000000985 |