دورية أكاديمية
Lemon myrtle extract inhibits lactate production by Streptococcus mutans
| العنوان: | Lemon myrtle extract inhibits lactate production by Streptococcus mutans |
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| المؤلفون: | Yabuta, Yukinori, Sato, Yui, Miki, Arisu, Nagata, Ryuta, Bito, Tomohiro, Ishihara, Atsushi, Watanabe, Fumio |
| المصدر: | Bioscience, Biotechnology, and Biochemistry ; volume 85, issue 10, page 2185-2190 ; ISSN 1347-6947 |
| بيانات النشر: | Informa UK Limited |
| سنة النشر: | 2021 |
| الوصف: | Backhousia citriodora (lemon myrtle) extract has been found to inhibit glucansucrase activity, which plays an important role in biofilm formation by Streptococcus mutans. In addition to glucansucrase, various virulence factors in S. mutans are involved in the initiation of caries. Lactate produced by S. mutans demineralizes the tooth enamel. This study investigated whether lemon myrtle extract can inhibit S. mutans lactate production. Lemon myrtle extract reduced the glycolytic pH drop in S. mutans culture and inhibited lactate production by at least 46%. Ellagic acid, quercetin, hesperetin, and myricetin, major polyphenols in lemon myrtle, reduced the glycolytic pH drop and lactate production, but not lactate dehydrogenase activity. Furthermore, these polyphenols reduced the viable S. mutans cell count. Thus, lemon myrtle extracts may inhibit S. mutans-mediated acidification of the oral cavity, thereby preventing dental caries and tooth decay. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/bbb/zbab147 |
| DOI: | 10.1093/bbb/zbab147/40303750/zbab147.pdf |
| الإتاحة: | https://doi.org/10.1093/bbb/zbab147Test https://academic.oup.com/bbb/article-pdf/85/10/2185/43369690/zbab147.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.7D68D716 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/bbb/zbab147 |
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