دورية أكاديمية
Microbial bionic nano-aromatic drugs for prevention of depression induced by chronic stress
| العنوان: | Microbial bionic nano-aromatic drugs for prevention of depression induced by chronic stress |
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| المؤلفون: | Ruiyuan Liu, Tianlu Zhang, Chaobo Bai, Jing Chen, Xin Zhang, Guiying Liu, Songjie Shen, Junliang Yuan, Zhiguo Lu |
| المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Microbial bionic nano-aromatic drugs, Aromatherapy, Prevention of depression, Chronic stress, Sustain release of essential oils, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Depression is a mood disorder mainly clinically characterized by significant and persistent low spirits. Chronic stress is the leading cause of depression. However, traditional medicine has severe side effects in treating depression, ineffective treatment, and easy recurrence. Therefore, it is of great significance to prevent depression in the environment of chronic stress. In this study, aromatherapy was used for the prevention of depression. To solve the defects of intense volatility and inconvenience in using essential oils, we designed bionic nano-aromatic drugs and adhered them to the wallpaper. Inspired by the moldy wallpaper, we successively prepared the morphology-bionic nano-aromatic drugs, the function-bionic nano-aromatic drugs, and the bionic plus nano-aromatic drugs by referring to the morphology of microorganisms and substances in bacterial biofilms. Bionic nano-aromatic drugs remarkably promoted their adhesion on wallpaper. Molecular dynamics simulation explored its molecular mechanism. The essential oils, which were slowly released from the bionic nano-aromatic drugs, showed excellent biosecurity and depression prevention. These sustainedly released essential oils could significantly increase monoamine neurotransmitters in the brain under a chronic stress environment and had excellent neuroprotection. Besides, the bionic nano-aromatic drugs with simple preparation process and low cost had excellent application potential. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| العلاقة: | https://doaj.org/toc/1477-3155Test |
| DOI: | 10.1186/s12951-024-02382-y |
| الوصول الحر: | https://doaj.org/article/a7188c48b97f40f3a9c1833e6de8d7ffTest |
| رقم الانضمام: | edsdoj.7188c48b97f40f3a9c1833e6de8d7ff |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-024-02382-y |