المؤلفون: Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

المساهمون: Novartis

المصدر: Cell Reports Medicine ; volume 4, issue 5, page 101036 ; ISSN 2666-3791

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.xcrm.2023.101036Test
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/plainTest

المؤلفون: Bussiere, Dirksen E., Xie, Lili, Srinivas, Honnappa, Shu, Wei, Burke, Ashley, Be, Celine, Zhao, Junping, Godbole, Adarsh, King, Dan, Karki, Rajeshri G., Hornak, Viktor, Xu, Fangmin, Cobb, Jennifer, Carte, Nathalie, Frank, Andreas O., Frommlet, Alexandra, Graff, Patrick, Knapp, Mark, Fazal, Aleem, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Beckwith, Rohan, Voshol, Hans, Wiesmann, Christian, Solomon, Jonathan M., Paulk, Joshiawa

المصدر: Nature Chemical Biology ; volume 16, issue 3, page 361-361 ; ISSN 1552-4450 1552-4469

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1038/s41589-020-0471-7Test
http://www.nature.com/articles/s41589-020-0471-7.pdfTest
http://www.nature.com/articles/s41589-020-0471-7Test

المؤلفون: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene, Zink, Florence

العلاقة: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene and Zink, Florence (2023) Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. ACS medicinal chemistry letters, 14 (8). pp. 1054-1062. ISSN 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test
https://oak.novartis.com/48414Test/
https://urldefense.com/v3/__https://pubs.acs.org/articlesonrequest/AOR-XMSQJCAESAJE7ANDBGJR__;!!N3hqHg43uw!uFA3uM4olcCL8tpKCJYXYyL3M18AlqJHvL11w9Hn1C8hAOd_Qr-Gh2R1bCZu3OuuUBvMawz8PHcn3D4u2P0BKWejMgTest$

المؤلفون: Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi, Zink, Florence, Zipfel, Géraldine, Hawtin, Stuart, Junt, Tobias, Michellys, Pierre-Yves

المساهمون: Novartis

المصدر: ACS Medicinal Chemistry Letters ; volume 14, issue 8, page 1054-1062 ; ISSN 1948-5875 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test

المؤلفون: Menichelli, Elena, Lam, Bianca J., Wang, Yu, Wang, Vivian S., Shaffer, Jennifer, Tjhung, Katrina F., Bursulaya, Badry, Nguyen, Truc, Vo, Michael, Alper, Phillip, McAllister, Christopher, Jones, David, Spraggon, Glen, Michellys, Pierre-Yves, Joslin, John, Joyce, Gerald F., Rogers, Jeff

العلاقة: Menichelli, Elena, Lam, Bianca J., Wang, Yu, Wang, Vivian S., Shaffer, Jennifer, Tjhung, Katrina F., Bursulaya, Badry, Nguyen, Truc, Vo, Michael, Alper, Phillip, McAllister, Christopher, Jones, David, Spraggon, Glen, Michellys, Pierre-Yves, Joslin, John, Joyce, Gerald F. and Rogers, Jeff (2022) Discovery of Small Molecules that Target a Tertiary-Structured RNA. Proceedings of the National Academy of Sciences of the United States of America PNAS., 119 (48). ISSN 0027-8424

الإتاحة: https://doi.org/10.1073/pnas.2213117119Test
https://oak.novartis.com/48618Test/

المؤلفون: Jonathan A. Deane, Stuart Hawtin, Roland Feifel, Pius Loetscher, Sarah Limonta, Tobias Junt, Ralf Glatthar, Michellys Pierre-Yves, Marjorie Bourrel, Thomas Knoepfel, Cedric Bernard Andre, Thomas Boulay, Pierre Nimsgern, Sebastien Jacquier, Eric Vangrevelinghe, Michael Faller, Claudia Betschart, Jutta Blank, Phillip B. Alper, Geraldine Collignon Zipfel, Dirk Behnke

المصدر: Journal of Medicinal Chemistry. 63:8276-8295

مصطلحات موضوعية: Male, Models, Molecular, Indazoles, Pyridones, Sequence alignment, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Lupus Erythematosus, Systemic, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Chemistry, Assay, Antagonist, virus diseases, TLR7, TLR8, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Toll-Like Receptor 7, Toll-Like Receptor 8, Molecular Medicine, Piperidine, Antagonism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a6d30a18c77cefd130b9738cd75108Test
https://doi.org/10.1021/acs.jmedchem.0c00130Test

المؤلفون: Kingsley, Laura, He, Xiaohui, McNeill, Matthew, Nelson, John, Nikulin, Victor, Ma, Zhiwei, Lu, Wenshuo, Zhou, Vicki, Manuia, Mari, Kreusch, Andreas, Gao, Mu-Yun, Witmer, Darbi, Vaillancourt, Mei Ting, Lu, Min, Greenblatt, Sarah, Lee, Christian, Bender, Steven, Spraggon, Glen, Michellys, Pierre, Jia, Yong, Haling, Jake, Lelais, Gerald

العلاقة: Kingsley, Laura, He, Xiaohui, McNeill, Matthew, Nelson, John, Nikulin, Victor, Ma, Zhiwei, Lu, Wenshuo, Zhou, Vicki, Manuia, Mari, Kreusch, Andreas, Gao, Mu-Yun, Witmer, Darbi, Vaillancourt, Mei Ting, Lu, Min, Greenblatt, Sarah, Lee, Christian, Bender, Steven, Spraggon, Glen, Michellys, Pierre, Jia, Yong, Haling, Jake and Lelais, Gerald (2021) Structure-based design of selective LONP1 inhibitors for probing in vitro biology. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c02152Test
https://oak.novartis.com/44486Test/