Improvement of patient outcomes following therapeutic optimization of chronic urticaria: two-year data from France as part of the international real-life AWARE study
| العنوان: | Improvement of patient outcomes following therapeutic optimization of chronic urticaria: two-year data from France as part of the international real-life AWARE study |
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| المؤلفون: | P.-A. Becherel, Michèle Debons-Peyroutet, Jean-Philippe Lacour, B. Pelvet, M. Ruer-Mulard, Audrey Lamirand, Frédéric Bérard, Pauline Pralong, Matthieu Greco, Françoise Giordano-Labadie, Gérard Guillet, Omar Outtas |
| المصدر: | European Journal of Dermatology. 31:217-224 |
| بيانات النشر: | John Libbey Eurotext, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Drug Resistance, Efficiency, Omalizumab, Dermatology, Disease, Severity of Illness Index, Treatment satisfaction, Patient satisfaction, Cost of Illness, Drug Therapy, Quality of life, Internal medicine, Anti-Allergic Agents, medicine, Humans, Chronic Urticaria, Patient Reported Outcome Measures, Prospective Studies, Chronic urticaria, Angioedema, Adult patients, business.industry, Middle Aged, Patient Satisfaction, Histamine H1 Antagonists, Quality of Life, Health Resources, Female, France, Sick Leave, medicine.symptom, business, Follow-Up Studies, medicine.drug |
| الوصف: | It is important to assess the burden of chronic urticaria (CU) with real-life studies. The AWARE study was performed in 36 countries over two years in CU patients resistant to H1-antihistamines.To correlate patient-reported outcomes and available therapeutic options in CU patients.The AWARE study was a prospective, non-interventional, international study that included adult patients who have had H1-antihistamine-resistant CU for at least two months. The primary endpoints were the evolution of disease activity (UAS7), urticaria control (UCT), dermatological quality of life (DLQI) and treatment satisfaction (visual analogic scale) during a two-year follow-up. The data from French centres are reported.Ninety-two patients were included (mean age: 47.8 years; women: 70.7%; mean disease duration: 6.5 years; angioedema: 34.1%). The percentage of patients with CU treatment increased from 56.5% at inclusion to 86.0% after two years (for patients with non-sedative H1-antihistamines from 52.2% to 74.4%, and omalizumab from 2.2% to 25.6%). During the follow-up, the percentage of patients with UAS7 score6 increased from 12.5% to 60.9%, and patients with well-controlled CU (UCT score12) increased from 11.1% to 62.2%. The negative impact on quality of life (DLQI10) decreased from 34.1% to 10.5%. The mean score of patient satisfaction for treatment increased from 4.6 to 7.6.The management of CU patients resistant to H1-antihistamines was not optimal at inclusion with uncontrolled disease, impaired quality of life and insufficient treatment. After a two-year follow-up, disease symptoms and quality of life improved, but the therapeutic management could be further optimized. |
| تدمد: | 1952-4013 1167-1122 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074b0f19e4abb6ea0ed9e3f53a6e7d5eTest https://doi.org/10.1684/ejd.2021.4023Test |
| رقم الانضمام: | edsair.doi.dedup.....074b0f19e4abb6ea0ed9e3f53a6e7d5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19524013 11671122 |
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