Clinical event rate in patients with and without left main disease undergoing isolated coronary artery bypass grafting: results from the European DuraGraft Registry

التفاصيل البيبلوغرافية
العنوان:	Clinical event rate in patients with and without left main disease undergoing isolated coronary artery bypass grafting: results from the European DuraGraft Registry
المؤلفون:	Caliskan, Etem, Misfeld, Martin, Sandner, Sigrid, Böning, Andreas, Aramendi, Jose, Salzberg, Sacha P, Choi, Yeong-Hoon, Perrault, Louis P, Tekin, Ilker, Cuerpo, Gregorio P, Lopez-Menendez, Jose, Weltert, Luca P, Böhm, Johannes, Krane, Markus, González-Santos, José M, Tellez, Juan-Carlos, Holubec, Tomas, Ferrari, Enrico, Emmert, Maximilian Y, Huenges, Katharina, Grubitzsch, Herko, Bakthiary, Farhad, Kempfert, Jörg, Penkalla, Adam J, Danner, Bernhard C, Jebran, Fawad A, Benstoem, Carina, Goetzenich, Andreas, Stoppe, Christian, Kuhn, Elmar W, Liakopoulos, Oliver J, Brose, Stefan, Matschke, Klaus, Veerasingam, Dave, Doddakula, Kishore, Wolf, Lorenzo Guerrieri, Serraino, Giuseppe Filiberto, Mastroroberto, Pasquale, Lamascese, Nicola, Sella, Massimo, Fajardo-Rodriguez, Edmundo R, Crespo, Alejandro, Gonález, Angel L Fernandez, Pedraz, Alvaro, Arnáiz-García, Elena, Carvajal, Ignacio Muñoz, Fontaine, Adrian J, Rodríguez, José Ramón González, Mera, José Antonio Corrales, Martinez, Paloma
المساهمون:	Marizyme, Jupiter, Florida, USA
المصدر:	European Journal of Cardio-Thoracic Surgery ; volume 62, issue 4 ; ISSN 1873-734X
بيانات النشر:	Oxford University Press (OUP)
سنة النشر:	2022
مصطلحات موضوعية:	Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, General Medicine, Surgery
الوصف:	OBJECTIVES Left main coronary artery disease (LMCAD) is considered an independent risk factor for clinical events after coronary artery bypass grafting (CABG). We have conducted a subgroup analysis of the multicentre European DuraGraft Registry to investigate clinical event rates at 1 year in patients with and without LMCAD undergoing isolated CABG in contemporary practice. METHODS Patients undergoing isolated CABG were selected. The primary end point was the incidence of a major adverse cardiac event (MACE) defined as the composite of death, myocardial infarction (MI) or repeat revascularization (RR) at 1 year. The secondary end point was major adverse cardiac and cerebrovascular events (MACCE) defined as MACE plus stroke. Propensity score matching was performed to balance for differences in baseline characteristics. RESULTS LMCAD was present in 1033 (41.2%) and absent in 1477 (58.8%) patients. At 1 year, the MACE rate was higher for LMCAD patients (8.2% vs 5.1%, P = 0.002) driven by higher rates of death (5.4% vs 3.4%, P = 0.016), MI (3.0% vs 1.3%, P = 0.002) and numerically higher rates of RR (2.8% vs 1.8%, P = 0.13). The incidence of MACCE was 8.8% vs 6.6%, P = 0.043, with a stroke rate of 1.0% and 2.4%, P = 0.011, for the LMCAD and non-LMCAD groups, respectively. After propensity score matching, the MACE rate was 8.0% vs 5.2%, P = 0.015. The incidence of death was 5.1% vs 3.7%, P = 0.10, MI 3.0% vs 1.4%, P = 0.020, and RR was 2.7% vs 1.6%, P = 0.090, for the LMCAD and non-LMCAD groups, respectively. Less strokes occurred in LMCAD patients (1.0% vs 2.4%, P = 0.017). The MACCE rate was not different, 8.5% vs 6.7%, P = 0.12. CONCLUSIONS In this large registry, LMCAD was demonstrated to be an independent risk factor for MACE after isolated CABG. Conversely, the risk of stroke was lower in LMCAD patients. Clinical trial registration number ClinicalTrials.gov NCT02922088.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1093/ejcts/ezac403
DOI:	10.1093/ejcts/ezac403/45275090/ezac403.pdf
الإتاحة:	https://doi.org/10.1093/ejcts/ezac403Test https://academic.oup.com/ejcts/article-pdf/62/4/ezac403/46052892/ezac403.pdfTest
حقوق:	https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest
رقم الانضمام:	edsbas.B96ED503
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1093/ejcts/ezac403