التفاصيل البيبلوغرافية
| العنوان: |
Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus |
| المؤلفون: |
Pei-Feng Zhu (8496804), Gui-Guang Cheng (1865215), Lan-Qin Zhao (10866098), Afsar Khan (665563), Xing-Wei Yang (681902), Bu-Yun Zhang (10866101), Meng-Cheng Li (10866104), Ya-Ping Liu (220100), Xiao-Dong Luo (1426072) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Microbiology, Pharmacology, Ecology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, FRAP, HepG -2 cells, reactive oxygen species production, ABTS, NMR, Rhynchanthus beesianus Rhynchanthus., H 2 O 2, DPPH, phenolic compounds, oxidative stress-connected diseases, antioxidant phenolic compounds, HRMS |
| الوصف: |
Rhynchanthus beesianus (Zingiberaceae) has been an important food spice and vegetable in southern China. Fifteen phenolic compounds ( 1 – 15 ) including three new diarylheptanoids, rhynchanines A–C ( 1 – 3 ) and one new phenylpropanoid, 4- O -methylstroside B ( 9 ), were isolated from R. beesianus rhizomes. The structures of new compounds were elucidated by comprehensive analyses through NMR, HRMS technique, acid hydrolysis, and Mosher’s reaction. Among them, compound 5 is the first isolated natural product and its NMR data are reported. Most of the isolated compounds, especially 3 – 6 and 8 , showed significant antioxidant activities on DPPH, ABTS + radical scavenging, and FRAP assays. Furthermore, the antioxidant phenolic compounds were evaluated for their cytoprotective capacity against H 2 O 2 -induced oxidative stress in HepG-2 cells. Compounds 3 and 5 could significantly inhibit reactive oxygen species production, and compounds 3 , 5 , and 6 could remarkably prevent the cell apoptosis. Then, the R. beesianus rhizome, which contained phenolic compounds, might serve as a functional food for potential application on preventing oxidative stress-connected diseases. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Antioxidant_and_Cytoprotective_Effects_of_New_Diarylheptanoids_from_Rhynchanthus_beesianus/14666126Test |
| DOI: |
10.1021/acs.jafc.1c00869.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jafc.1c00869.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.FEBA42B4 |
| قاعدة البيانات: |
BASE |
