دورية أكاديمية
Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma
| العنوان: | Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma |
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| المؤلفون: | Gollrad, Johannes, Rabsahl, Christopher, Riechardt, Aline-Isabel, Heufelder, Jens, Stroux, Andrea, Goerling, Ute, Joussen, Antonia, Budach, Volker, Boehmer, Dirk |
| المصدر: | http://lobid.org/resources/99370675069706441Test#!, 16(1):174. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Female [MeSH], Aged, 80 and over [MeSH], Proton Therapy/adverse effects [MeSH], Aged [MeSH], Adult [MeSH], Humans [MeSH], Prospective Studies [MeSH], Melanoma/radiotherapy [MeSH], Clinical Radiation Oncology, Middle Aged [MeSH], Melanoma/psychology [MeSH], Proton therapy, Proton Therapy/methods [MeSH], Quality of life, Male [MeSH], Uveal Neoplasms/radiotherapy [MeSH], Quality of Life [MeSH], Research, Young Adult [MeSH], Uveal melanoma, Uveal Neoplasms/psychology [MeSH] |
| الوصف: | Background!#!Proton beam therapy is a well-established treatment option for patients with uveal melanoma (UM). The treatment procedure, in general, includes placing radiopaque clips to ensure exact eye-positioning during radiotherapy, followed by the delivery of proton irradiation. The short-term burden associated with proton therapy in patients with UM has rarely been addressed. In this prospective study, we investigated the physiological and psychological aspects of proton therapy that might affect the well-being of patients during the different stages of treatment.!##!Methods!#!During the treatment procedure, we conducted longitudinal assessments of the Quality of life (QOL), organ-specific symptoms, and psychological aspects in patients with UM with three questionnaires (EORTC QLQ-C30, EORTC QLQ-OPT30, and GAD-7). Patients completed questionnaires before clip surgery (T0), before proton therapy (T1), after completing treatment (T2), and three months after treatment completion (T3). We also collected data on tumor characteristics and socio-demographics to identify potential risk factors associated with high treatment burdens.!##!Results!#!We prospectively included 131 consecutive patients. Questionnaire data showed a significant, temporary decline in global QOL and an increase in eye-related symptoms, as a result of the clip surgery (T0-T1). After treatment completion (T2), global QOL improved gradually, and none of the eye-related symptoms significantly deteriorated over the course of proton therapy. The global QOL returned to baseline levels three months after treatment (T3). We identified baseline anxiety as an independent risk factor for experiencing an acute treatment-related burden. Furthermore, we found interactions between GAD7 and patient sex showing that anxiety had a more pronounced effect on QOL outcome in female patients.!##!Conclusion!#!The short-term treatment-related burden of ocular proton therapy appeared to be largely associated with the preceding clip surgery, rather than the irradiation ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6463457Test; https://doi.org/10.1186/s13014-021-01902-6Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425039Test/ |
| DOI: | 10.1186/s13014-021-01902-6 |
| الإتاحة: | https://doi.org/10.1186/s13014-021-01902-6Test https://repository.publisso.de/resource/frl:6463457Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425039Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C22E7695 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13014-021-01902-6 |
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