دورية أكاديمية
Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels
| العنوان: | Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels |
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| المؤلفون: | Martín-Núñez, Gracia Mª, Cornejo-Pareja, Isabel, Clemente-Postigo, Mercedes, Tinahones, Francisco J., Moreno-Indias, Isabel |
| المساهمون: | Martín-Núñez,GM, Cornejo-Pareja,I, Tinahones,FJ, Moreno-Indias,I Department of Endocrinology and Nutrition, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, Spain. Martín-Núñez,GM, Clemente-Postigo,M, Moreno-Indias,I Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Clemente-Postigo,M Department of Cell Biology, Physiology, and Immunology, Maimónides Biomedical Research Institute of Córdoba (IMIBIC)/University of Córdoba/Reina Sofia University Hospital, Córdoba, Spain., GMM-N was supported by a Juan de la Cierva, Formación contract (FJCI-2017-34349) from the Spanish Ministry of Science, Innovation and Universities (Spain). IC-P was supported by Rio Hortega (CM 17/00169), and is now the recipient of a postdoctoral grant Juan Rodes from the Spanish Ministry of Economy and Competitiveness (ISCIII), and cofounded by Fondo Europeo de Desarrollo Regional-FEDER (JR 19/00054). MC-P was recipient of a postdoctoral grant Juan de la Cierva Formación (FJCI-2017-32194) from the Ministerio de Ciencia, Innovación y Universidades (Spain) and postdoctoral research grant (DOC_00448) from the Consejeria de Economía, Industria, Conocimiento y Universidades (PAIDI 2020, Junta de Andalucía), Spain, cofounded by the Fondo Europeo de Desarrollo Regional (FEDER). IM-I was supported by the MS type I program (CP16/00163) from the Instituto de Salud Carlos III and co-funded by Fondo Europeo de Desarrollo Regional FEDER. The funding organizations played no role in the present manuscript. This work was supported in part by a grant from the Instituto de Salud Carlos III co-funded by Fondo Europeo de Desarrollo Regional-FEDER, PI14/00082, PI15/01114, PI18/01160Madrid, Spain, and by the Centros de Investigación Biomédica en Red (CIBER) of the Institute of Health Carlos III (ISCIII) (CB06/03/0018). |
| بيانات النشر: | Frontiers |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Helicobacter pylori, Gut microbiota, Ghrelin, Eradication treatment, Antibiotic, Microbioma gastrointestinal, Ghrelina, Antibacterianos, Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Helicobacter::Helicobacter pylori, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Erythromycin::Clarithromycin, Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Ghrelin, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents, Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Anaerobic Bacteria::Gram-Negative Anaerobic Straight, Curved, and Helical Rods::Bacteroidaceae::Bacteroides, Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Anaerobic Bacteria::Gram-Negative Anaerobic Cocci::Megasphaera |
| الوصف: | Background: Antibiotic therapy used to eradicate Helicobacter pylori has been associated with changes in plasma ghrelin and alterations in the gut microbiota. On the other hand, changes in ghrelin levels have been related to changes in gut microbiota composition. Our aim was to evaluate the relationship between changes in the gut microbiota and ghrelin levels in H. pylori infected patients who received antibiotic treatment for its eradication. Methods: A prospective case-control study that included forty H. pylori-positive patients who received eradication therapy (omeprazole, clarithromycin, and amoxicillin) and twenty healthy H. pylori antigen-negative participants. Patients were evaluated, including clinical, anthropometric and dietary variables, before and 2 months after treatment. Gut microbiota composition was analyzed through 16S rRNA amplicon sequencing (IlluminaMiSeq). Results: Changes in gut microbiota profiles and decrease in ghrelin levels were identified after H. pylori eradication treatment. Gut bacteria such as Bifidobacterium longum, Bacteroides, Prevotella, Parabacteroides distasonis, and RS045 have been linked to ghrelin levels fasting and/or post meals. Changes in the abundance of Lachnospiraceae, its genus Blautia, as well as Prevotella stercorea, and Megasphaera have been inversely associated with changes in ghrelin after eradication treatment. Conclusions: Eradication treatment for H. pylori produces changes in the composition of the intestinal microbiota and ghrelin levels. The imbalance between lactate producers such as Blautia, and lactate consumers such as Megasphaera, Lachnospiraceae, or Prevotella, could trigger changes related to ghrelin levels under the alteration of the eradication therapy used for H. pylori. In addition, acetate producing bacteria such as B. longum, Bacteroides, and P. distasonis could also play an important role in ghrelin regulation. ; Yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-858X |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fmed.2021.712908/fullTest; Martín-Núñez GM, Cornejo-Pareja I, Clemente-Postigo M, Tinahones FJ, Moreno-Indias I. Helicobacter pylori Eradication Therapy Affect the Gut Microbiota and Ghrelin Levels. Front Med. 2021 Aug 12;8:712908; http://hdl.handle.net/10668/3501Test; PMC8387937 |
| DOI: | 10.3389/fmed.2021.712908 |
| الإتاحة: | https://doi.org/10.3389/fmed.2021.712908Test http://hdl.handle.net/10668/3501Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.B706ED54 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296858X |
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| DOI: | 10.3389/fmed.2021.712908 |