التفاصيل البيبلوغرافية
| العنوان: |
Use of an artificial pancreas among adolescents for a missed snack bolus and an underestimated meal bolus. |
| المؤلفون: |
Cherñavvsky, Daniel R, DeBoer, Mark D, Keith‐Hynes, Patrick, Mize, Benton, McElwee, Molly, Demartini, Susan, Dunsmore, Spencer F, Wakeman, Christian, Kovatchev, Boris P, Breton, Marc D |
| المصدر: |
Pediatric Diabetes; Feb2016, Vol. 17 Issue 1, p28-35, 8p, 1 Diagram, 1 Chart, 2 Graphs |
| مصطلحات موضوعية: |
ARTIFICIAL organs, HYPOGLYCEMIA, PANCREAS, TREATMENT of diabetes, CARBOHYDRATES, DIABETES, PEOPLE with diabetes, GLYCOSYLATED hemoglobin, HOME care services, INFORMED consent (Medical law), INGESTION, INSULIN pumps, TYPE 1 diabetes, PATIENT safety, RESEARCH funding, SNACK foods, DATA analysis, RANDOMIZED controlled trials, CONTROL groups, PATIENT selection, DESCRIPTIVE statistics, GLYCEMIC control, DIAGNOSIS, ANATOMY |
| الشركة/الكيان: |
UNITED States. Food & Drug Administration |
| مستخلص: |
Objective The objective of this study was to evaluate the safety and performance of the artificial pancreas ( AP) in adolescents with type 1 diabetes ( T1D) following insulin omission for food. Research design and methods In a randomized, cross-over trial, adolescents with T1D aged 13-18 yr were enrolled in a randomized, cross-over trial. On separate days, received either usual care ( UC) through their home insulin pump or used an AP system (Diabetes Assistant platform, continuous glucose monitor, and insulin pump). Approximately 1 h after admission, participants in both groups received an unannounced snack of 30 g carbohydrate, and 4 h later they received an 80 g lunch, for which both groups only received 75% of the calculated insulin dose to cover carbohydrates. On the UC day (but not the AP day), they received their full high blood glucose ( BG) correction factor at lunch. Each admission lasted approximately 8 h. Results A total of 16 participants completed the trial. On the AP day (compared to UC), mean BG was lower (197 ± 10 vs. 235 ± 14 mg/ dL) and time in range 70-180 mg/ dL was higher (43% ± 7 vs. 19% ± 7) (both p < 0.05) overall; these results held in the time following the snack and meal (also p < 0.05). During the trial, there were no differences between groups in the rate of hypoglycemia <70 mg/ dL. Conclusions The AP provided improvements in short-term glycemic control without increases in hypoglycemia following missed insulin for food in adolescents. Thus, the AP partly compensates for missed insulin boluses for food, a common occurrence in adolescent diabetes care. Further testing is needed in longer-term settings. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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