المؤلفون: Matthew A. Cerny, Douglas K. Spracklin, R. Scott Obach

المصدر: Drug Metabolism and Disposition. 51:647-656

مصطلحات موضوعية: Pharmacology, Pharmaceutical Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4c81e540d25cba62b9d4044ff411e6e9Test
https://doi.org/10.1124/dmd.122.001006Test

المؤلفون: Christine C. Orozco, Mikko Neuvonen, Yi-An Bi, Matthew A. Cerny, Sumathy Mathialagan, Laurie Tylaska, Brian Rago, Chester Costales, Amanda King-Ahmad, Mikko Niemi, A. David Rodrigues

المصدر: Molecular Pharmaceutics.

مصطلحات موضوعية: Drug Discovery, Pharmaceutical Science, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9fe363351e5280805205ea7705113770Test
https://doi.org/10.1021/acs.molpharmaceut.3c00040Test

المؤلفون: David Rodrigues, Mark Niosi, Heather Eng, Christopher Healy, Sarah Lazzaro, Qingyi Yang, Matthew A. Cerny

المصدر: The Journal of Clinical Pharmacology.

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::57c1f73918803b48c098f6d1f89b00f0Test
https://doi.org/10.1002/jcph.2235Test

المؤلفون: Heather Eng, Theunis C. Goosen, Jian Lin, Matthew A. Cerny, R. Scott Obach, Elaine E. Tseng, David A. Tess

المصدر: Drug Metabolism and Disposition. 49:947-960

مصطلحات موضوعية: Drug, Time Factors, Metabolic Clearance Rate, CYP3A, media_common.quotation_subject, Pharmacokinetic modeling, Pharmaceutical Science, Pharmacology, Models, Biological, Drug Development, Predictive Value of Tests, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Biotransformation, media_common, Cytochrome P450 3A, Human liver, Chemistry, Reproducibility of Results, virus diseases, Enzyme Activation, Dynamic models, Drug Design, Hepatocytes, Microsomes, Liver, Microsome, Cytochrome P-450 CYP3A Inhibitors, Geometric mean

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803b29b300056a42da5a7eb10db6e944Test
https://doi.org/10.1124/dmd.121.000497Test

المؤلفون: Heather Eng, Elaine E. Tseng, R. Scott Obach, Theunis C. Goosen, Matthew A. Cerny

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 49(6)

مصطلحات موضوعية: Drug, Time Factors, CYP3A, media_common.quotation_subject, Pharmaceutical Science, Boundary line, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Reaction rate constant, Drug Development, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Enzyme Inhibitors, media_common, Cytochrome P450 3A, Human liver, Chemistry, In vitro toxicology, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Inactivation, Metabolic, Microsome, Hepatocytes, Microsomes, Liver, Cytochrome P-450 CYP3A Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839e08a224f63a40c1ec078c67d88fd7Test
https://pubmed.ncbi.nlm.nih.gov/33811106Test

المؤلفون: Matthew A. Cerny, A. David Rodrigues, Brian Rago, Sarah Lazzaro, Ragu Ramanathan, Chester Costales, Mikko Neuvonen, Aleksi Tornio, Manthena V.S. Varma, Mark A. West, Sumathy Mathialagan, Päivi Hirvensalo, Mikko Niemi

المساهمون: HUSLAB, Department of Clinical Pharmacology, Department of Diagnostics and Therapeutics, University of Helsinki, Helsinki University Hospital Area, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Medicum

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Male, Pharmacogenomic Variants, 030226 pharmacology & pharmacy, 0302 clinical medicine, Tandem Mass Spectrometry, Genotype, ANION TRANSPORTING POLYPEPTIDE, CYNOMOLGUS MONKEYS, Pharmacology (medical), DRUG-INTERACTION, Oligonucleotide Array Sequence Analysis, BILE-ACIDS, biology, Chemistry, Liver-Specific Organic Anion Transporter 1, Articles, Healthy Volunteers, 3. Good health, Organic anion-transporting polypeptide, POLYMORPHISM MARKEDLY AFFECTS, Phenotype, Liver, 317 Pharmacy, 030220 oncology & carcinogenesis, ENDOGENOUS BIOMARKERS, Biomarker (medicine), Female, Glucuronide, Adult, medicine.medical_specialty, PLASMA-CONCENTRATIONS, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Young Adult, Glucuronides, Glycochenodeoxycholic Acid, Internal medicine, SLCO1B1 POLYMORPHISM, medicine, Humans, HAPLOTYPE RECONSTRUCTION, Pharmacology, Receiver operating characteristic, Research, Haplotype, GENOME-WIDE, In vitro, Metabolic Detoxication, Phase II, Endocrinology, HEK293 Cells, biology.protein, SLCO1B1, Biomarkers, Chromatography, Liquid, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bbecde5bac675897f44df4cf2a0148Test
https://pubmed.ncbi.nlm.nih.gov/32961594Test

المؤلفون: R. Scott Obach, Amit S. Kalgutkar, Gregory S. Walker, Matthew A. Cerny, Raman Sharma, Douglas K. Spracklin

المصدر: Journal of medicinal chemistry. 63(12)

مصطلحات موضوعية: Drug, 0303 health sciences, Drug-Related Side Effects and Adverse Reactions, Molecular Structure, Chemistry, media_common.quotation_subject, Computational biology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Structure-Activity Relationship, Strategic approach, Drug Development, Pharmaceutical Preparations, Metabolite profiling, Drug Design, Reactive metabolite, Drug Discovery, Metabolome, Molecular Medicine, Humans, Safety testing, 030304 developmental biology, media_common

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7175ff9b5835dc2b486861b0446b2f53Test
https://pubmed.ncbi.nlm.nih.gov/32097005Test

المؤلفون: Neil Moss, Lee Fader, Jeremy R Richman, Stanley Kugler, Matthew A. Cerny, Jennifer Burke, Raquel Arenas, Derek Cogan, Federico Colombo, Maolin Yu, Kosea Frederick, John Lord, Zhidong Chen, Jean-Huges Parmentier, Balestra Michael, Nicholas F. Brown, Steven M. Weldon, Xin Guo, Daniel R. Goldberg, Michael Zhang, Holly Clifford, Jennifer Schmenk, Kenneth M. Meyers, Daniel Richard Marshall, Keith R Hornberger

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:979-984

مصطلحات موضوعية: 0301 basic medicine, Aldosterone synthase, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Cytochrome P-450 CYP11B2, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Aldosterone, Dose-Response Relationship, Drug, Molecular Structure, ATP synthase, biology, Organic Chemistry, Isoxazoles, Metabolism, In vitro, 030104 developmental biology, Enzyme, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Hepatocyte, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b0efa78c0594d187a77fbd86938a66Test
https://doi.org/10.1016/j.bmcl.2017.12.015Test

المؤلفون: Ryan M, Fryer, Khing Jow, Ng, Suzanne G, Nodop Mazurek, Lori, Patnaude, Donna J, Skow, Akalushi, Muthukumarana, Kyle E, Gilpin, Roger M, Dinallo, Daniel, Kuzmich, John, Lord, Sulagna, Sanyal, Hui, Yu, Christian, Harcken, Matthew A, Cerny, Matthew C, Cerny, Eugene R, Hickey, Louise K, Modis

المصدر: Journal of Pharmacology and Experimental Therapeutics. 348:421-431

مصطلحات موضوعية: Male, medicine.medical_specialty, Stimulation, CHO Cells, In Vitro Techniques, Nitric Oxide, Receptors, G-Protein-Coupled, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Cricetulus, Dogs, In vivo, Cricetinae, Internal medicine, Cyclic AMP, medicine, Animals, Humans, Rats, Wistar, Receptor, Pharmacology, Endothelin-1, business.industry, Imidazoles, Arteries, Triazoles, Iberiotoxin, Colitis, G protein-coupled bile acid receptor, Potassium channel, Rats, Vasodilation, Thyroxine, Pyrimidines, Endocrinology, chemistry, Cytokines, Molecular Medicine, Dinitrofluorobenzene, business, Atrial Natriuretic Factor, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d49d84857eb02b186bf7f533e87e9bTest
https://doi.org/10.1124/jpet.113.210005Test

المؤلفون: Kosea Frederick, Alexander Csengery, Matthew A. Cerny, Jennifer Schmenk

المصدر: The Journal of Steroid Biochemistry and Molecular Biology. 154:197-205

مصطلحات موضوعية: Aldosterone synthase, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biochemistry, chemistry.chemical_compound, Endocrinology, Mineralocorticoid receptor, Corticosterone, Internal medicine, Adrenal Glands, medicine, Animals, Cytochrome P-450 CYP11B2, Humans, Steroid 11-beta-hydroxylase, Molecular Biology, chemistry.chemical_classification, Aldosterone, biology, Adrenal gland, Cell Biology, Kinetics, Macaca fascicularis, medicine.anatomical_structure, Enzyme, chemistry, Zona glomerulosa, Models, Animal, biology.protein, Steroid 11-beta-Hydroxylase, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24878bf5a959ad347692ffb309c1910Test
https://doi.org/10.1016/j.jsbmb.2015.08.004Test