دورية أكاديمية
Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data
| العنوان: | Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data |
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| المؤلفون: | Broger, T, Koeppel, L, Huerga, H, Miller, P, Gupta-Wright, A, Blanc, FX, Esmail, A, Reeve, BWP, Floridia, M, Kerkhoff, AD, Ciccacci, F, Kasaro, MP, Thit, SS, Bastard, M, Ferlazzo, G, Yoon, C, Van Hoving, DJ, Sossen, B, García, JI, Cummings, MJ, Wake, RM, Hanson, J, Cattamanchi, A, Meintjes, G, Maartens, G, Wood, R, Theron, G, Dheda, K, Olaru, ID, Denkinger, CM, Oelofse, S, Laureillard, D, Andreotti, M, Chilyabanyama, ON, Welu, B, Molfino, L, Mathabire Rücker, SC, Szumilin, E, Cossa, L, Meléndez, J, Mbuthini, L, O'Donnell, M, Jarvis, JN, Ndlangalavu, G, Fielding, K |
| المصدر: | urn:ISSN:2572-116X ; urn:ISSN:2214-109X ; The Lancet Global Health, 11, 6, e903-e916 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | Tuberculosis, HIV/AIDS, Clinical Research, Rare Diseases, Infectious Diseases, Infection, 3 Good Health and Well Being, Humans, Male, Female, Sputum, Bayes Theorem, Cross-Sectional Studies, Lipopolysaccharides, HIV Infections, Sensitivity and Specificity, Mycobacterium tuberculosis, TBYield Study Consortium, anzsrc-for: 0605 Microbiology, anzsrc-for: 1117 Public Health and Health Services |
| الوصف: | Background: Sputum is the most widely used sample to diagnose active tuberculosis, but many people living with HIV are unable to produce sputum. Urine, in contrast, is readily available. We hypothesised that sample availability influences the diagnostic yield of various tuberculosis tests. Methods: In this systematic review and meta-analysis of individual participant data, we compared the diagnostic yield of point-of-care urine-based lipoarabinomannan tests with that of sputum-based nucleic acid amplification tests (NAATs) and sputum smear microscopy (SSM). We used microbiologically confirmed tuberculosis based on positive culture or NAAT from any body site as the denominator and accounted for sample provision. We searched PubMed, Web of Science, Embase, African Journals Online, and clinicaltrials.gov from database inception to Feb 24, 2022 for randomised controlled trials, cross-sectional studies, and cohort studies that assessed urine lipoarabinomannan point-of-care tests and sputum NAATs for active tuberculosis detection in participants irrespective of tuberculosis symptoms, HIV status, CD4 cell count, or study setting. We excluded studies in which recruitment was not consecutive, systematic, or random; provision of sputum or urine was an inclusion criterion; less than 30 participants were diagnosed with tuberculosis; early research assays without clearly defined cutoffs were tested; and humans were not studied. We extracted study-level data, and authors of eligible studies were invited to contribute deidentified individual participant data. The main outcomes were the tuberculosis diagnostic yields of urine lipoarabinomannan tests, sputum NAATs, and SSM. Diagnostic yields were predicted using Bayesian random-effects and mixed-effects meta-analyses. This study is registered with PROSPERO, CRD42021230337. Findings: We identified 844 records, from which 20 datasets and 10 202 participants (4561 [45%] male participants and 5641 [55%] female participants) were included in the meta-analysis. All studies assessed ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/1959.4/unsworks_83662Test; https://doi.org/10.1016/s2214-109xTest(23)00135-3 |
| DOI: | 10.1016/s2214-109x(23)00135-3 |
| الإتاحة: | https://doi.org/10.1016/s2214-109xTest(23)00135-3 http://hdl.handle.net/1959.4/unsworks_83662Test |
| حقوق: | metadata only access ; http://purl.org/coar/access_right/c_14cbTest ; CC-BY ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.5894312B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/s2214-109x(23)00135-3 |
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