التفاصيل البيبلوغرافية
| العنوان: |
Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction. |
| المؤلفون: |
Martínez-Shio, Elena Berenice1 (AUTHOR), Marín-Jáuregui, Laura Sherell1 (AUTHOR), Rodríguez-Ortega, Alma Celeste1 (AUTHOR), Doníz-Padilla, Lesly Marsol1 (AUTHOR), González-Amaro, Roberto1 (AUTHOR), Escobedo-Uribe, Carlos David2 (AUTHOR), Monsiváis-Urenda, Adriana Elizabeth1 (AUTHOR) aurenda@gmail.com |
| المصدر: |
Clinical & Experimental Immunology. Jun2024, Vol. 216 Issue 3, p262-271. 10p. |
| مصطلحات موضوعية: |
*MYOCARDIAL infarction, *VENTRICULAR dysfunction, *REGULATORY T cells, *T cells, *ACUTE coronary syndrome |
| مستخلص: |
A high percentage of patients with acute coronary syndrome develop heart failure due to the ischemic event. Regulatory T (Treg) cells are lymphocytes with suppressive capacity that control the immune response and include the conventional CD4+ CD25hi Foxp3+ cells and the CD4+ CD25var CD69+ LAP+ Foxp3− IL-10+ cells. No human follow-up studies focus on Treg cells' behavior after infarction and their possible relationship with ventricular function as a sign of postischemic cardiac remodeling. This study aimed to analyze, by flow cytometry, the circulating levels of CD69+ Treg cells and CD4+ CD25hi Foxp3+ cells, their IL-10+ production as well as their function in patients with acute myocardial infarction (AMI), and its possible relation with ventricular dysfunction. We found a significant difference in the percentage of CD4+ CD25hi Foxp3+ cells and IL-10+ MFI in patients with AMI at 72 hours compared with the healthy control group, and the levels of these cells were reduced 6 months post-AMI. Regarding the suppressive function of CD4+ CD25+ regulatory cells, they were dysfunctional at 3 and 6 months post-AMI. The frequency of CD69+ Treg cells was similar between patients with AMI at 72 hours postinfarction and the control groups. Moreover, the frequency of CD69+ Treg cells at 3 and 6 months postischemic event did not vary over time. Treg cells play a role in regulating inflammation after an AMI, and its function may be compromised in this pathology. This work is the first report to evaluate CD69+ Foxp3− Treg cells in AMI patients. A high percentage of patients with acute coronary syndrome develop heart failure due to the ischemic event. Regulatory T cells play a role in regulating inflammation after an acute myocardial infarction and its function may be compromised in this pathology. This work is the first report to evaluate CD69+ Foxp3− Treg cells in acute myocardial infarction patients. Graphical Abstract [ABSTRACT FROM AUTHOR] |
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