يعرض 1 - 10 نتائج من 10 نتيجة بحث عن '"Mark G. Fulton"', وقت الاستعلام: 3.54s تنقيح النتائج
  1. 1
    Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

    المؤلفون: Charles David Weaver, Emily Days, Craig W. Lindsley, Alice L. Rodriguez, Paige N. Vinson, Colleen M. Niswender, Anna L. Blobaum, Matthew T. Loch, Caroline Anne Cuoco, P.J. Conn, Krystian A. Kozek, Mark G. Fulton

    المصدر: Letters in Drug Design & Discovery

    مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Allosteric regulation, Pharmaceutical Science, Carboxamide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Drug Discovery, medicine, Structure–activity relationship, metabotropic glutamate receptor, Receptor, Xanthine oxidase inhibitor, Heterodimer, striatopallidal synapses, 030304 developmental biology, Letters in Drug Design & Discovery, 0303 health sciences, mGlu2/4, Chemistry, structure-activity relationship, Metabotropic glutamate receptor, positive allosteric modulator, Molecular Medicine, Febuxostat, 030217 neurology & neurosurgery, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12744d2df7d05c9a81a50373a85b8687Test
    https://doi.org/10.2174/1570180815666181017131349Test


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  2. 2
    Formal Total Synthesis of Pericoannosin A

    المؤلفون: Jeanette L. Bertron, Mark G. Fulton, Carson W. Reed, Craig W. Lindsley

    المصدر: The Journal of Organic Chemistry. 84:12187-12191

    مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Total synthesis, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Hydroboration, chemistry.chemical_compound, Chain (algebraic topology), Yield (chemistry), Isoprene

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4018ecc3827f9cd44bc78caeecf42cTest
    https://doi.org/10.1021/acs.joc.9b01846Test


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  3. 3
    Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli

    المؤلفون: Charles Cirio, Herman van Tilbeurgh, Mark G Fulton, Charles T. Lauhon, S. Missoury, Brett J. Kopina, Bruno Collinet

    المساهمون: University of Wisconsin-Madison, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Nucleic Acids Research
    Nucleic Acids Research, 2021, ⟨10.1093/nar/gkab026⟩
    Nucleic Acids Research, Oxford University Press, 2021, ⟨10.1093/nar/gkab026⟩

    مصطلحات موضوعية: Models, Molecular, TRNA modification, Adenosine, AcademicSubjects/SCI00010, Stereochemistry, [SDV]Life Sciences [q-bio], Organophosphonates, Reaction intermediate, 03 medical and health sciences, chemistry.chemical_compound, RNA, Transfer, Catalytic Domain, Escherichia coli, Genetics, 030304 developmental biology, 0303 health sciences, biology, Nucleic Acid Enzymes, Escherichia coli Proteins, 030302 biochemistry & molecular biology, Rational design, Active site, Phosphonate, Small molecule, chemistry, Transfer RNA, Mutagenesis, Site-Directed, biology.protein, Protein Multimerization, Oxyanion hole

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25be9170c566e6d516fe181b3752133Test
    https://hal.sorbonne-universite.fr/hal-03134410Test


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  4. 4
    Discovery and optimization of a novel CNS penetrant series of mGlu

    المؤلفون: Caitlin N, Kent, Mark G, Fulton, Kaylee J, Stillwell, Jonathan W, Dickerson, Matthew T, Loch, Alice L, Rodriguez, Anna L, Blobaum, Olivier, Boutaud, Jerri L, Rook, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley

    المصدر: Bioorganicmedicinal chemistry letters. 37

    مصطلحات موضوعية: Catalepsy, Disease Models, Animal, Mice, Structure-Activity Relationship, Neuroprotective Agents, Allosteric Regulation, Dose-Response Relationship, Drug, Molecular Structure, Drug Discovery, Animals, Haloperidol, Parkinson Disease, Receptors, Metabotropic Glutamate

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::aa0e4acb766ebacc10e8996ddcf9fb14Test
    https://pubmed.ncbi.nlm.nih.gov/33556572Test


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  5. 5
    Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

    المؤلفون: Juan Vicente Sanchez-Andres, Jerod S. Denton, Mark G. Fulton, Craig W. Lindsley, Christopher S. Hofmann, Sujay V. Kharade, Anna L. Blobaum, Prasanna K. Dadi, David A. Jacobson, Darren W. Engers, Elaine L. Shelton, Louise Lantier

    المصدر: J Pharmacol Exp Ther

    مصطلحات موضوعية: 0301 basic medicine, endocrine system, Pharmacology, Sulfonylurea Receptors, 03 medical and health sciences, Drug Discovery and Translational Medicine, Mice, Structure-Activity Relationship, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Diazoxide, medicine, Animals, Humans, Potassium Channels, Inwardly Rectifying, Ion channel, Membrane potential, Chemistry, Kir6.2, Ductus Arteriosus, Hyperpolarization (biology), medicine.disease, Potassium channel, Vasodilation, 030104 developmental biology, Glucose, HEK293 Cells, Xanthines, cardiovascular system, Molecular Medicine, Sulfonylurea receptor, Hyperinsulinism, Ion Channel Gating, 030217 neurology & neurosurgery, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e1791742f94d2f116a26d1e849a38eTest
    https://europepmc.org/articles/PMC6691189Test/


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  6. 6
    Total synthesis of natural (−)- and unnatural (+)-Melearoride A

    المؤلفون: Kellie D. Nance, Carson W. Reed, Craig W. Lindsley, Mark G. Fulton

    المصدر: Tetrahedron Letters. 60:743-745

    مصطلحات موضوعية: Antifungal, Analog synthesis, 010405 organic chemistry, Longest linear sequence, Chemistry, Stereochemistry, medicine.drug_class, Organic Chemistry, Total synthesis, Alkylation, 010402 general chemistry, Metathesis, 01 natural sciences, Biochemistry, 0104 chemical sciences, Drug Discovery, medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4f6571be3358b24fbfef90edb600bf64Test
    https://doi.org/10.1016/j.tetlet.2019.02.006Test


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  7. 7
    Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model

    المؤلفون: Kaylee J. Stillwell, Jonathan W. Dickerson, Matthew T. Loch, Craig W. Lindsley, Mark G. Fulton, Olivier Boutaud, P. Jeffrey Conn, Colleen M. Niswender, Caitlin N. Kent, Alice L. Rodriguez, Jerri L. Rook, Anna L. Blobaum

    المصدر: Bioorganic & Medicinal Chemistry Letters. 37:127838

    مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Catalepsy, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Cns penetration, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Molecular Medicine, Penetrant (biochemical), Molecular Biology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8982a8ca4fb9fbb1b11c0095cf87e8fbTest
    https://doi.org/10.1016/j.bmcl.2021.127838Test


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  8. 8
    Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity

    المؤلفون: Jonathan A. Javitch, Colleen M. Niswender, Alice L. Rodriguez, P. Jeffrey Conn, Matthew T. Loch, Xin Lin, Craig W. Lindsley, Mark G. Fulton

    المصدر: Bioorg Med Chem Lett

    مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Ligands, Receptors, Metabotropic Glutamate, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, Glutamatergic, Allosteric Regulation, parasitic diseases, Drug Discovery, Animals, Humans, Homomeric, G protein-coupled inwardly-rectifying potassium channel, Protein Structure, Quaternary, Receptor, Molecular Biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Small molecule, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Metabotropic glutamate receptor, Cell culture, Benzamides, Indans, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b3d6f0170e32b132342614e9740e3aTest
    https://doi.org/10.1016/j.bmcl.2020.127212Test


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  9. 9
    Total synthesis of violaceimides A–E and consideration of the reported stereochemistry

    المؤلفون: Charles K. Perry, Mark G. Fulton, Craig W. Lindsley

    المصدر: Tetrahedron Letters. 60:151103

    مصطلحات موضوعية: 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Diastereomer, Enantioselective synthesis, Total synthesis, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Aspergillus violaceus, Drug Discovery, Spectral data, Sign (mathematics)

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::decd5d424a9587c2ffe23dc34aa1f6e6Test
    https://doi.org/10.1016/j.tetlet.2019.151103Test


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  10. 10
    Development of novel inhibitors of swelling‐activated LRRC8 anion channels

    المؤلفون: Mark G. Fulton, Craig W. Lindsley, Jerod S. Denton, David R. Weaver, Eric E. Figueroa, Sujay V. Kharade, Meghan Kramer

    المصدر: The FASEB Journal. 32

    مصطلحات موضوعية: Chemistry, Genetics, Biophysics, medicine, Swelling, medicine.symptom, Molecular Biology, Biochemistry, Biotechnology, Ion

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::187392a7049bd28a827086db20877217Test
    https://doi.org/10.1096/fasebj.2018.32.1_supplement.567.3Test


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