نتائج البحث - "Mark A. Jarosinski"

1

دورية أكاديمية

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

المؤلفون: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss

المصدر: Frontiers in Endocrinology, Vol 13 (2022)

مصطلحات موضوعية: monogenic diabetes, endoplasmic reticular stress, peptide chemistry, protein folding, oxidative folding intermediate, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2022.821069/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/ac8abdb348a7445ab68c20aba3dbef24Test

View record in DOAJ

النص الكامل

2

دورية أكاديمية

Structural principles of insulin formulation and analog design: A century of innovation

المؤلفون: Mark A. Jarosinski, Balamurugan Dhayalan, Yen-Shan Chen, Deepak Chatterjee, Nicolás Varas, Michael A. Weiss

المصدر: Molecular Metabolism, Vol 52, Iss , Pp 101325- (2021)

مصطلحات موضوعية: Protein engineering, Pharmacodynamics, Insulin action, Insulin signaling, Molecular pharmacology, Internal medicine, RC31-1245

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2212877821001721Test; https://doaj.org/toc/2212-8778Test

الوصول الحر: https://doaj.org/article/934701eebaff4526bc2d5c33215bdbfaTest

View record in DOAJ

النص الكامل

3

‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues

المؤلفون: Deepak Chatterjee, Mark A. Jarosinski, Balamurugan Dhayalan, Michael A. Weiss, Nischay K. Rege

المصدر: Diabetologia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2225e21e72676d79f8bb4bfabbac9bbTest
https://doi.org/10.1007/s00125-021-05422-6Test

4

New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals

المؤلفون: Deepak Chatterjee, Yen-Shan Chen, Balamurugan Dhayalan, Michael A. Weiss, Mark A. Jarosinski, Nicolás Varas

المصدر: J Clin Endocrinol Metab

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f993bf47482f5da4d0dfdc9c63dca53Test
https://europepmc.org/articles/PMC8947325Test/

5

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation

المؤلفون: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss

المصدر: Frontiers in endocrinology. 13

مصطلحات موضوعية: Protein Folding, Adolescent, Endocrinology, Diabetes and Metabolism, Diabetes Mellitus, Humans, Insulin, Disulfides, Peptides, Proinsulin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76981e7bf5dc8d1ca68ff3e3d55e6c55Test
https://pubmed.ncbi.nlm.nih.gov/35299972Test

6

DataSheet_1_Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation.pdf

المؤلفون: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss

مصطلحات موضوعية: Endocrinology, Reproduction, Cell Metabolism, monogenic diabetes, endoplasmic reticular stress, peptide chemistry, protein folding, oxidative folding intermediate

العلاقة: https://figshare.com/articles/dataset/DataSheet_1_Peptide_Model_of_the_Mutant_Proinsulin_Syndrome_I_Design_and_Clinical_Correlation_pdf/19270979Test

الإتاحة: https://doi.org/10.3389/fendo.2022.821069.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Peptide_Model_of_the_Mutant_Proinsulin_Syndrome_I_Design_and_Clinical_Correlation_pdf/19270979Test

View record in BASE

7

Age of diabetes onset in the mutant proinsulin syndrome correlates with mutational impairment of protein foldability and stability

المؤلفون: Peter Arvan, Faramarz Ismail-Beigi, Yanwu Yang, Mark A. Jarosinski, Balamurugan Dhayalan, Nelson B. Phillips, Rachel Grabowski, Shayan Poordian, Michael A. Weiss, Deepak Chatterjee, Yen-Shan Chen

مصطلحات موضوعية: Chemistry, Endoplasmic reticulum, Mole, Mutant, Protein folding, Gene, Molecular biology, In vitro, Molten globule, Proinsulin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4a197901d7b98e37cca9a1f2401bf8f3Test
https://doi.org/10.1101/2021.09.24.461687Test

8

Structural principles of insulin formulation and analog design: A century of innovation

المؤلفون: Nicolás Varas, Deepak Chatterjee, Yen-Shan Chen, Mark A. Jarosinski, Michael A. Weiss, Balamurugan Dhayalan

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 52, Iss, Pp 101325-(2021)

مصطلحات موضوعية: Blood Glucose, IGF, insulin-like growth factor, Computer science, medicine.medical_treatment, Chemistry, Pharmaceutical, Insulins, Review, Chemistry Techniques, Synthetic, Protein Engineering, Protein structure, time in range. Amino acids are designated by standard three-letter code, residue numbers in insulin are shown by chain in superscript. Names of insulin analogs are italicized in lower case whereas tradenames of products are capitalized without italics, NPH, neutral protamine Hagedorn, Internal medicine, PEG, polyethylene-glycol, biology, GLP-1RA, glucagon-like peptide 1 receptor agonist, FRI, fructose responsive insulin, T1D, type 1 diabetes mellitus, Molecular Pharmacology, Insulin signaling, FDA, United States Food & Drug Administration, Insulin analog, Computational biology, GLUT1, glucose transporter 1, CGM, continuous glucose monitor, PK, pharmacokinetic, History, 21st Century, IR, insulin receptor (isoforms IR-A or IR-B), medicine, Diabetes Mellitus, Animals, Humans, GLP-1, glucagon-like peptide 1, GRI, glucose-responsive insulin, Molecular Biology, cryo-EM, cryogenic electron microscopy, Insulin action, HbA1c, hemoglobin A1c, Insulin, SQ, subcutaneous, Cell Biology, Protein engineering, SCI, single-chain insulin, History, 20th Century, RC31-1245, T2D type 2 diabetes mellitus, TiR, Insulin receptor, Disease Models, Animal, GPCR, G-protein coupled receptor, Structural biology, Basal (medicine), Pharmacodynamics, FRC, fixed-ratio combination, Drug Design, biology.protein, Molecular pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0709598066ae9bc3f7328c43341d4683Test
http://europepmc.org/articles/PMC8513154Test

9

Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges

المؤلفون: Balamurugan Dhayalan, Mamuni Swain, Norman Metanis, Michael A. Weiss, Faramarz Ismail-Beigi, Mark A. Jarosinski, Ali Mirsalehi, Nischay K. Rege, Yen-Shan Chen, Nelson B. Phillips

المصدر: Chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc45731b4026ab050095f7a3e85c91d7Test
https://pubmed.ncbi.nlm.nih.gov/31958351Test

10

Insertion of a Synthetic Switch Into Insulin Provides Metabolite-Dependent Regulation of Hormone-Receptor Activation

المؤلفون: Balamurugan Dhayalan, Laurie Broadwater, Yanwu Yang, Thomas Hattier, Jeremy Gleaton, Nelson B. Phillips, Deepak Chatterjee, Yen-Shan Chen, Michael C. Lawrence, Michael A. Weiss, M. Dodson Michael, Mark A. Jarosinski, Yule Liu

المصدر: Journal of the Endocrine Society
Proc Natl Acad Sci U S A

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Conformational change, Protein Conformation, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Blotting, Western, Allosteric regulation, Dysregulated Metabolic Response, Insulin analog, Fructose, Ligands, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Insulin, Receptor, Multidisciplinary, biology, Chemistry, Autophosphorylation, Hep G2 Cells, Biological Sciences, Ligand (biochemistry), Diabetes Mellitus and Glucose Metabolism, Insulin receptor, 030104 developmental biology, Hormone receptor, 030220 oncology & carcinogenesis, biology.protein, Biophysics, AcademicSubjects/MED00250, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28213b7d202309d177cc495f6bc734aTest
http://europepmc.org/articles/PMC8090162Test

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