Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers
| العنوان: | Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers |
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| المؤلفون: | Christian Geraut, Claude Roedlich, Frederique Naudin, E. Chailleux, François Raffi, Marietherese Houdebine, David Boutoille, Jean-Yves Muller, Albert Nienhaus, Anja Schablon, Dominique Tripodi, Charlotte Biron, P. Germaud, Gilles Potel, Claire Gordeeff, Benedicte Brunet-Courtois, M. Audrain, Virginie Nael, Martine Bourrut-Lacouture, Guyonne Guillaumin, Marie-Henriette Durand-Perdriel |
| المصدر: | Journal of Occupational Medicine and Toxicology (London, England) Journal of Occupational Medicine and Toxicology, Vol 4, Iss 1, p 30 (2009) |
| بيانات النشر: | BioMed Central, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Tuberculosis, business.industry, Public health, Research, Pharmacology toxicology, Public Health, Environmental and Occupational Health, Tuberculin, Tb screening, Skin test, Toxicology, medicine.disease, bacterial infections and mycoses, lcsh:RC963-969, Interferon γ, Internal medicine, Health care, lcsh:Industrial medicine. Industrial hygiene, Medicine, business, Safety Research |
| الوصف: | Introduction Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-γ Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients. Methods Between May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST ≥ 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered. Results All HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST ≥ 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation. Conclusion The introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST. |
| اللغة: | English |
| تدمد: | 1745-6673 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a7534f4856760dd7100461840be475Test http://europepmc.org/articles/PMC2790451Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e9a7534f4856760dd7100461840be475 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17456673 |
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