Human papillomavirus independent status on pathologic response and outcomes in locally advanced cervical cancer managed with chemoradiotherapy followed by surgery
| العنوان: | Human papillomavirus independent status on pathologic response and outcomes in locally advanced cervical cancer managed with chemoradiotherapy followed by surgery |
|---|---|
| المؤلفون: | Luigi Carlo Turco, Luigi Pedone Anchora, Camilla Fedele, Frediano Inzani, Alessia Piermattei, Maurizio Martini, Mariaconcetta Volpe, Simona Marchetti, Rosaria Santangelo, Nicolò Bizzarri, Francesco Cosentino, Virginia Vargiu, Maria De Ninno, Gabriella Macchia, Vincenzo Valentini, Gianfranco Zannoni, Giovanni Scambia, Gabriella Ferrandina |
| المصدر: | International Journal of Gynecologic Cancer. 33:489-497 |
| بيانات النشر: | BMJ, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, cervical cancer, Obstetrics and Gynecology, pathology, radiotherapy |
| الوصف: | ObjectiveWhile human papillomavirus (HPV) has been shown to play a significant role in cervical cancer carcinogenesis (HPV associated cases), a considerable percentage of cervical cancers occur independently of HPV status (HPV independent).MethodsIn this retrospective study of 254 locally advanced cervical cancer patients treated with chemoradiotherapy and radical surgery, HPV genotypes were determined using the Anyplex II HPV28 kit that uses multiplex, real time polymerase chain reaction technology. The primary endpoints of this study were to evaluate the complete response to chemoradiotherapy (pathologic complete response), the presence of microscopic (<3 mm, pathologic micro partial response, group 1) and macroscopic (>3 mm, pathologic macro partial response, group 2) residual carcinoma in the cervix, and the persistence of metastatic lymph nodes (group 3) in HPV independent cervical cancers. Secondary endpoints were evaluation of disease-free survival and overall survival.ResultsOf 254 patients studied, 21 cases (8.3%) of cervical cancer were determined to be HPV independent. The percentage of pathologic complete response was found to be higher in the HPV associated group compared with the HPV independent group (pConclusionsThis study showed that HPV status at diagnosis could be a relevant factor for clinical outcomes in locally advanced cervical cancer patients. |
| تدمد: | 1525-1438 1048-891X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24af9b08c508011395e1aea6590b773fTest https://doi.org/10.1136/ijgc-2022-003940Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....24af9b08c508011395e1aea6590b773f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251438 1048891X |
|---|