Possible involvement ofhMLH1, p16INK4a andPTEN in the malignant transformation of endometriosis
| العنوان: | Possible involvement ofhMLH1, p16INK4a andPTEN in the malignant transformation of endometriosis |
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| المؤلفون: | Maria Vita Ciccarone, Claudia Maggiore, Giorgia Garganese, Siavash Rahimi, Luigi Maria Larocca, Giorgio Vittori, Maurizio Martini, Gian Franco Zannoni, Antonella Evangelista |
| المصدر: | International Journal of Cancer. 102:398-406 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Cancer Research, Pathology, medicine.medical_specialty, Adolescent, DNA Repair, Tumor suppressor gene, Endometriosis, medicine.disease_cause, Polymerase Chain Reaction, Malignant transformation, Immunoenzyme Techniques, Carcinoma, medicine, Humans, PTEN, Neoplastic transformation, neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Adaptor Proteins, Signal Transducing, biology, Tumor Suppressor Proteins, PTEN Phosphohydrolase, Nuclear Proteins, Cancer, DNA, Neoplasm, DNA Methylation, Middle Aged, Prognosis, medicine.disease, Phosphoric Monoester Hydrolases, digestive system diseases, Endometrial Neoplasms, Neoplasm Proteins, Cell Transformation, Neoplastic, Oncology, Cancer research, biology.protein, Female, Carrier Proteins, MutL Protein Homolog 1, Carcinogenesis, Precancerous Conditions, Adenocarcinoma, Clear Cell, Microsatellite Repeats |
| الوصف: | Endometriosis is a common gynecologic disease, which generally follows a benign course. Notwithstanding, several clinical and histologic studies as well as molecular data show that endometriosis could be a precursor of sporadic endometrioid and clear cell carcinomas at extrauterine loci. Several reports have implicated alterations of the hMLH1 and p16ink4a(p16) genes, in particular hypermethylation of the promoter region, and of the PTEN gene, principally genetic mutations, in endometrial and ovarian cancers and have indicated that these alterations are already present in precancer conditions. In this report, we analyzed the methylation status of hMLH1 and p16 and the protein expression of PTEN and hMLH1 in 46 cases of endometriosis stages III and IV to better define the possible involvement of these genes in the malignant transformation of endometriosis. We found abnormal methylation of hMLH1 in 4 of the 46 cases (8.6%). In addition, these cases had no detectable hMLH1 protein expression. Regarding patients with hMLH1 alterations, 2 were classified as stage IV and 2 showed coexistent endometriosis and carcinoma. Only 1 case of endometriosis (2.17%), classified as atypical, showed abnormal methylation of p16. Reduced PTEN protein expression was detected in 7 of 46 cases (15.21%): 5 were clinically classified as stage IV, and the other 2 presented both cancer and hypermethylated hMLH1. Our preliminary study suggests that reduced expression of both hMLH1 and PTEN may be involved in the malignant evolution of endometriosis and should be used as markers of neoplastic transformation in aggressive endometriosis with elevated tumor markers. © 2002 Wiley-Liss, Inc. |
| تدمد: | 1097-0215 0020-7136 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2b4fe1c3d565084a7987d30e7ff088Test https://doi.org/10.1002/ijc.10715Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f2b4fe1c3d565084a7987d30e7ff088 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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