المؤلفون: Santiago Schiaffino-Ortega, Elena Mariotto, Pilar María Luque-Navarro, María Kimatrai-Salvador, Pablo Rios-Marco, Ramon Hurtado-Guerrero, Carmen Marco, María Paz Carrasco-Jimenez, Giampietro Viola, Luisa Carlota López-Cara

المصدر: Pharmaceutics; Volume 13; Issue 9; Pages: 1360

مصطلحات موضوعية: antitumoral drug, choline kinase inhibition, choline uptake

وصف الملف: application/pdf

العلاقة: Biologics and Biosimilars; https://dx.doi.org/10.3390/pharmaceutics13091360Test

الإتاحة: https://doi.org/10.3390/pharmaceutics13091360Test

المؤلفون: Paola Oliva, Romeo Romagnoli, Elena Mariotto, Luisa Carlota Lopez-Cara, Salvatore Ferla, Maria Kimatrai Salvador, Elena Mattiuzzo, Andrea Brancale, Mariem Chayah, Filippo Prencipe, Ernest Hamel, Giampietro Viola, Roberto Ronca, Roberta Bortolozzi, Santiago Schiaffino Ortega, Stefania Baraldi, Pier Giovanni Baraldi

المصدر: Journal of Medicinal Chemistry. 62:1274-1290

مصطلحات موضوعية: Drug Evaluation, Preclinical, Apoptosis, Microtubules, 01 natural sciences, Polymerization, chemistry.chemical_compound, Pyrimidine analogue, derivates, Drug Discovery, Epidermal growth factor receptor, vascular disrupting agents, tyrosine kinase, EGFR inhibitors, colchicine site, lung cancer,tubulin, anticancer, thienopyrimidine, discovery, derivates, Membrane Potential, Mitochondrial, 0303 health sciences, biology, Kinase, Cell Cycle, tyrosine kinase, thienopyrimidine, ErbB Receptors, Biochemistry, vascular disrupting agents, Molecular Medicine, Poly(ADP-ribose) Polymerases, Tyrosine kinase, Pyrimidine, macromolecular substances, anticancer, NO, 03 medical and health sciences, Enzyme activator, Microtubule, Cell Line, Tumor, colchicine site, Humans, Cell Proliferation, 030304 developmental biology, EGFR inhibitors, Drug Discovery3003 Pharmaceutical Science, Vascular Endothelial Growth Factor Receptor-2, 0104 chemical sciences, Enzyme Activation, lung cancer, 010404 medicinal & biomolecular chemistry, Pyrimidines, Tubulin, tubulin, chemistry, Drug Design, biology.protein, Colchicine, Reactive Oxygen Species, discovery, HeLa Cells

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3d60e2108fe51c21f512f9adf41556Test
https://doi.org/10.1021/acs.jmedchem.8b01391Test

المؤلفون: Giampietro Viola, Paola Oliva, Stefano Manfredini, Elena Mariotto, Ernest Hamel, Roberta Bortolozzi, Maria Kimatrai Salvador, Federica Maccarinelli, Salvatore Ferla, Chiara Padroni, Fatlum Rruga, Andrea Brancale, Roberto Ronca, Romeo Romagnoli

مصطلحات موضوعية: Antimitotic agents, Antiproliferative activity, Drug Screening Assays, 01 natural sciences, Polymerization, chemistry.chemical_compound, Tubulin, Drug Discovery, Colchicine, Pyrrole, 0303 health sciences, Tumor, Molecular Structure, biology, 1H-pyrrole, Structure-activity relationship, Tubulin polymerization, General Medicine, Cell cycle, Tubulin Modulators, Drug, Stereochemistry, Antineoplastic Agents, Antimitotic Agents, Cell Line, Tumor, Cell Proliferation, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Pyrroles, Structure-Activity Relationship, NO, Cell Line, Dose-Response Relationship, 03 medical and health sciences, In vivo, Structure–activity relationship, 030304 developmental biology, Pharmacology, Combretastatin, 010405 organic chemistry, Organic Chemistry, Antitumor, 0104 chemical sciences, chemistry, Cell culture, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5316dca49836f1fdec2a055781f34911Test
https://cronfa.swan.ac.uk/Record/cronfa56997Test

المؤلفون: Roberta Bortolozzi, Andrea Brancale, Filippo Prencipe, Salvatore Ferla, Romeo Romagnoli, Dominique Schols, Sandra Liekens, Paola Oliva, Leentje Persoons, Jan Balzarini, Giampietro Viola, Maria Kimatrai Salvador, Ernest Hamel

مصطلحات موضوعية: Indoles, Stereochemistry, Substituent, Antineoplastic Agents, Antiproliferative activity, Alkylation, 01 natural sciences, Biochemistry, Microtubules, NO, chemistry.chemical_compound, Microtubule, Indole, Structure-activity relationship, Tubulin, Cell Line, Tumor, Neoplasms, Drug Discovery, Humans, Moiety, Structure–activity relationship, Molecular Biology, Cell Proliferation, Indole test, Combretastatin, biology, 010405 organic chemistry, Organic Chemistry, Tubulin Modulators, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, biology.protein, Drug Screening Assays, Antitumor

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fb7e8864d749837ecf0cdb504393fcTest
http://hdl.handle.net/11577/3337007Test

المؤلفون: Romeo Romagnoli, Ernest Hamel, Giampietro Viola, Salvatore Ferla, Andrea Brancale, Maria Kimatrai Salvador, Paola Oliva, Roberto Ronca, Roberta Bortolozzi, Elena Mariotto, Fatlum Rruga, Chiara Padroni, Elisabetta Grillo, Maria Encarnacion Camacho

المصدر: European journal of medicinal chemistry. 181

مصطلحات موضوعية: Models, Molecular, Stereochemistry, 1H-pyrazole, Antiproliferative activity, Microtubules, Structure-activity relationship, Tubulin, Animals, Antineoplastic Agents, Bibenzyls, Cell Line, Tumor, Drug Design, Humans, Mice, Pyrazoles, Tubulin Modulators, Pyrazole, 01 natural sciences, Cell Line, NO, 03 medical and health sciences, chemistry.chemical_compound, Models, Drug Discovery, Moiety, Structure–activity relationship, 030304 developmental biology, Pharmacology, Combretastatin A-4, Combretastatin, 0303 health sciences, Tumor, biology, 010405 organic chemistry, Aryl, Organic Chemistry, Molecular, General Medicine, 1H-pyrazole, Antiproliferative activity, Microtubules, Structure-activity relationship, Tubulin, 0104 chemical sciences, chemistry, Alkoxy group, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba70aa0bb1f682eef81988b30fc8a60Test
https://pubmed.ncbi.nlm.nih.gov/31400707Test

المؤلفون: Elena Mattiuzzo, Sandra Liekens, Paola Oliva, Andrea Brancale, Giampietro Viola, Pier Giovanni Baraldi, Ernest Hamel, Santiago Schiaffino Ortega, Romeo Romagnoli, Luisa Carlota Lopez-Cara, Maria Kimatrai Salvador, Giuseppe Basso, Salvatore Ferla, Jan Balzarini, Stefania Baraldi

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Apoptosis, Drug Screening Assays, Antiproliferative agents, Colchicine site, Microtubule, Structure-activity relationship, Tubulin polymerization inhibitors, Animals, Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Membrane Potential, Mitochondrial, Mice, Microtubules, Molecular Structure, Polymerization, Reactive Oxygen Species, Structure-Activity Relationship, Thiophenes, Tubulin, Tubulin Modulators, Drug Design, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, HeLa, chemistry.chemical_compound, 0302 clinical medicine, Models, Drug Discovery, Thiophene, Tumor, biology, General Medicine, Mitochondrial, 030220 oncology & carcinogenesis, Drug, Stereochemistry, Membrane Potential, Article, NO, Cell Line, Dose-Response Relationship, 03 medical and health sciences, Structure–activity relationship, Combretastatin, Cell growth, Molecular, Antitumor, biology.organism_classification, 030104 developmental biology, chemistry, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b66f801166c66640da5f9f0923b5438Test
http://hdl.handle.net/11577/3254722Test

المؤلفون: Ernest Hamel, Roberta Bortolozzi, Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Elena Mariotto, Elena Porcù, Roberto Ronca, Luisa Carlota Lopez-Cara, Giuseppe Basso, Giampietro Viola, Stefania Baraldi, Filippo Prencipe, Salvatore Ferla, Pier Giovanni Baraldi, Andrea Brancale

المساهمون: Romagnoli, Romeo, Baraldi, Pier Giovanni, Prencipe, Filippo, Oliva, Paola, Baraldi, Stefania, Salvador, Maria Kimatrai, Lopez Cara, Luisa Carlota, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Ronca, Roberto, Bortolozzi, Roberta, Mariotto, Elena, Porcù, Elena, Basso, Giuseppe, Viola, Giampietro

المصدر: Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Apoptosis, Chemistry Techniques, Synthetic, Pharmacology, Mice, chemistry.chemical_compound, Tubulin, Colchicine, Oxazoles, Tumor, Multidisciplinary, Molecular Structure, biology, Cell Cycle, Cell cycle, Tubulin Modulators, Mitochondria, Molecular Docking Simulation, OxazolesPoly(ADP-ribose) Polymerases, Biochemistry, Poly(ADP-ribose) Polymerases, Human, Signal Transduction, Animals, Apoptosis, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Chemistry Techniques, Synthetic, DNA Damage, Humans, Mice, Mitochondria, Molecular Docking Simulation, Molecular Dynamics Simulation, Molecular Structure, OxazolesPoly(ADP-ribose) Polymerases, Protein Multimerization, Signal Transduction, Tubulin, Tubulin Modulators, Xenograft Model Antitumor Assays, Molecular Dynamics Simulation, Article, NO, Cell Line, 03 medical and health sciences, In vivo, Cell Line, Tumor, Tubulin Modulator, Animals, Humans, Cell Proliferation, Combretastatin, Chemistry Technique, Animal, Synthetic, Apoptosi, Chemistry Techniques, Xenograft Model Antitumor Assays, In vitro, 030104 developmental biology, chemistry, Cell culture, biology.protein, DNA Damage, Protein Multimerization, Antimitotic Agent, OxazolesPoly(ADP-ribose) Polymerase

وصف الملف: ELETTRONICO; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74f7e90e55448158b231cbf105a9be5Test
https://doi.org/10.1038/srep46356Test

المؤلفون: Paola Oliva, Stefania Baraldi, Giuseppe Basso, Romeo Romagnoli, Pier Giovanni Baraldi, Elena Mattiuzzo, Roberta Bortolozzi, Maria Kimatrai Salvador, Luisa Carlota Lopez-Cara, Giampietro Viola, Filippo Prencipe

المساهمون: Romagnoli, Romeo, Baraldi, Pier Giovanni, Prencipe, Filippo, Oliva, Paola, Baraldi, Stefania, Salvador, Maria Kimatrai, Lopez Cara, Luisa Carlota, Bortolozzi, Roberta, Mattiuzzo, Elena, Basso, Giuseppe, Viola, Giampietro

مصطلحات موضوعية: 0301 basic medicine, Indoles, Apoptosis, Drug Screening Assays, 2-Oxindole derivatives, In , chemistry.chemical_compound, 0302 clinical medicine, GSH depletion, In vitro antiproliferative activity, Michael acceptor, α-bromoacryloyl, Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Drug Screening Assays, Antitumor, Glutathione, Humans, Membrane Potential, Mitochondrial, Neoplasms, Reactive Oxygen Species, Structure-Activity Relationship, Drug Design, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, In vitro antiproliferative activity, α-bromoacryloyl, Drug Discovery, 2-Oxindole derivative, chemistry.chemical_classification, Tumor, General Medicine, Mitochondrial, Biochemistry, 030220 oncology & carcinogenesis, medicine.symptom, Pharmacophore, Intracellular, Stereochemistry, vitro antiproliferative activity, Membrane Potential, Cell Line, NO, 03 medical and health sciences, medicine, IC50, Reactive oxygen species, Inundefined vitro antiproliferative activity, Antitumor, In vitro, Oxindoles, 030104 developmental biology, Mechanism of action, chemistry, Cell culture

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa4adc66023d7185140617bf65b81eaTest
http://hdl.handle.net/11392/2368302Test

المؤلفون: Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Filippo Prencipe, Carlota Lopez Cara, Santiago Schiaffino Ortega, Andrea Brancale, Ernest Hamel, Ignazio Castagliuolo, Stefania Mitola, Roberto Ronca, BORTOLOZZI, ROBERTA, Elena Porcù, BASSO, GIUSEPPE, VIOLA, GIAMPIETRO

المساهمون: Romeo, Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Filippo, Prencipe, Carlota Lopez Cara, Santiago Schiaffino Ortega, Andrea, Brancale, Ernest, Hamel, Castagliuolo, Ignazio, Stefania, Mitola, Roberto, Ronca, Bortolozzi, Roberta, Elena, Porcù, Basso, Giuseppe, Viola, Giampietro

مصطلحات موضوعية: Angiogenesis Inhibitor, Animal, Antineoplastic Agent, Apoptosi, Benzofuran, Binding Site, Cell Line, Tumor, Cell Proliferation, Chemistry Techniques, Synthetic, Chick Embryo, Colchicine, Dose-Response Relationship, Drug, Drug Design, Human, Male, Mice, Inbred BALB C, Inbred C57BL, Models, Molecular, Molecular Targeted Therapy, Structure-Activity Relationship, Tubulin

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25785605; info:eu-repo/semantics/altIdentifier/wos/WOS:000353091300020; ispartofbook:Journal of Medicinal Chemistry; volume:58; issue:7; firstpage:3209; lastpage:3222; numberofpages:14; journal:JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11577/3156600Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84927647021

الإتاحة: https://doi.org/10.1021/acs.jmedchem.5b00155Test
http://hdl.handle.net/11577/3156600Test

المؤلفون: ROMAGNOLI, Romeo, BARALDI, Pier Giovanni, Maria Kimatrai Salvador, Mariem Chayah, M. Encarnacion Camacho, PRENCIPE, Filippo, Ernest Hamel, Francesca Consolaro, Giuseppe Basso, Giampietro Viola

المساهمون: Romagnoli, Romeo, Baraldi, Pier Giovanni, Maria Kimatrai, Salvador, Mariem, Chayah, M., Encarnacion Camacho, Prencipe, Filippo, Ernest, Hamel, Francesca, Consolaro, Giuseppe, Basso, Giampietro, Viola

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000338598400037; volume:81; firstpage:394; lastpage:407; numberofpages:14; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11368/3019569Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84901250470

الإتاحة: http://hdl.handle.net/11368/3019569Test