Fixed dynamometry is more sensitive than vital capacity or ALS rating scale
| العنوان: | Fixed dynamometry is more sensitive than vital capacity or ALS rating scale |
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| المؤلفون: | Helen E. Stephens, Robert A. English, Mary Proffitt Bunnell, Merit Cudkowicz, Katherine A Fetterman, Catherine Siener, Julaine Florence, Patricia L. Andres, Eric A. Macklin, Zachary Simmons, Edward J. Kasarskis, Margaret Allred, Travis Haines |
| المصدر: | Muscle & Nerve. 56:710-715 |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Longitudinal study, medicine.medical_specialty, Physiology, Vital Capacity, Muscle Strength Dynamometer, Isometric exercise, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Muscle nerve, Physical medicine and rehabilitation, Rating scale, Isometric Contraction, Physiology (medical), medicine, Humans, Longitudinal Studies, Muscle Strength, 030212 general & internal medicine, Amyotrophic lateral sclerosis, Alsfrs r, business.industry, Amyotrophic Lateral Sclerosis, Outcome measures, Middle Aged, medicine.disease, Sample size determination, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017 |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f1d603d7ed183262ab876140876badTest https://doi.org/10.1002/mus.25586Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....13f1d603d7ed183262ab876140876bad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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